Population-Based Survival Analysis of Patients With Limb Rhabdomyosarcoma and Metastasis at Diagnosis

Purpose: Given the poor prognosis and the relative rarity of patients diagnosed with limb rhabdomyosarcoma (LRMS) and metastasis at diagnosis, we performed this study to reveal distinctive clinical features and evaluated prognostic factors of this special population in order to provide appropriate t...

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Autores principales:	Chunying Yang, Haiqing Wang, Feng Niu, Lufeng Yao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	limb rhabdomyosarcoma (LRMS) metastasis at diagnosis survival analysis tumor subtype radiotherapy Surgery RD1-811
Acceso en línea:	https://doaj.org/article/6362fc55b9204d448216e6dd3fcfcfba
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spelling	oai:doaj.org-article:6362fc55b9204d448216e6dd3fcfcfba2021-11-04T05:19:09ZPopulation-Based Survival Analysis of Patients With Limb Rhabdomyosarcoma and Metastasis at Diagnosis2296-875X10.3389/fsurg.2021.738771https://doaj.org/article/6362fc55b9204d448216e6dd3fcfcfba2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fsurg.2021.738771/fullhttps://doaj.org/toc/2296-875XPurpose: Given the poor prognosis and the relative rarity of patients diagnosed with limb rhabdomyosarcoma (LRMS) and metastasis at diagnosis, we performed this study to reveal distinctive clinical features and evaluated prognostic factors of this special population in order to provide appropriate treatment.Patients and Methods: We carried out retrospective research of patients diagnosed with LRMS and metastasis from 1975 to 2016 using the Surveillance, Epidemiology, and End Results (SEER) program database. Survival curves were generated by applying the Kaplan–Meier method. In terms of evaluating and determining independent predictors of survival, we conducted univariate and multivariate survival analyses using the Cox proportional hazard regression model.Results: This retrospective analysis contained a series of 245 patients with metastatic LRMS, with male predominance (male vs. female, 1.6:1). Nearly half of the patients were diagnosed with alveolar rhabdomyosarcoma (44.9%). According to the results of the univariate and multivariate analyses, younger age, tumor subtype, and radiotherapy were found to be significantly associated with improved overall survival (OS) and cause-specific survival (CSS).Conclusions: Patients with LRMS and metastasis at diagnosis experienced a quite poor prognosis. Age at diagnosis, tumor subtype, and radiotherapy can help clinicians to better estimate the prognosis. This study indicated that local radiotherapy can provide a survival benefit.Chunying YangHaiqing WangFeng NiuLufeng YaoFrontiers Media S.A.articlelimb rhabdomyosarcoma (LRMS)metastasis at diagnosissurvival analysistumor subtyperadiotherapySurgeryRD1-811ENFrontiers in Surgery, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	limb rhabdomyosarcoma (LRMS) metastasis at diagnosis survival analysis tumor subtype radiotherapy Surgery RD1-811
spellingShingle	limb rhabdomyosarcoma (LRMS) metastasis at diagnosis survival analysis tumor subtype radiotherapy Surgery RD1-811 Chunying Yang Haiqing Wang Feng Niu Lufeng Yao Population-Based Survival Analysis of Patients With Limb Rhabdomyosarcoma and Metastasis at Diagnosis
description	Purpose: Given the poor prognosis and the relative rarity of patients diagnosed with limb rhabdomyosarcoma (LRMS) and metastasis at diagnosis, we performed this study to reveal distinctive clinical features and evaluated prognostic factors of this special population in order to provide appropriate treatment.Patients and Methods: We carried out retrospective research of patients diagnosed with LRMS and metastasis from 1975 to 2016 using the Surveillance, Epidemiology, and End Results (SEER) program database. Survival curves were generated by applying the Kaplan–Meier method. In terms of evaluating and determining independent predictors of survival, we conducted univariate and multivariate survival analyses using the Cox proportional hazard regression model.Results: This retrospective analysis contained a series of 245 patients with metastatic LRMS, with male predominance (male vs. female, 1.6:1). Nearly half of the patients were diagnosed with alveolar rhabdomyosarcoma (44.9%). According to the results of the univariate and multivariate analyses, younger age, tumor subtype, and radiotherapy were found to be significantly associated with improved overall survival (OS) and cause-specific survival (CSS).Conclusions: Patients with LRMS and metastasis at diagnosis experienced a quite poor prognosis. Age at diagnosis, tumor subtype, and radiotherapy can help clinicians to better estimate the prognosis. This study indicated that local radiotherapy can provide a survival benefit.
format	article
author	Chunying Yang Haiqing Wang Feng Niu Lufeng Yao
author_facet	Chunying Yang Haiqing Wang Feng Niu Lufeng Yao
author_sort	Chunying Yang
title	Population-Based Survival Analysis of Patients With Limb Rhabdomyosarcoma and Metastasis at Diagnosis
title_short	Population-Based Survival Analysis of Patients With Limb Rhabdomyosarcoma and Metastasis at Diagnosis
title_full	Population-Based Survival Analysis of Patients With Limb Rhabdomyosarcoma and Metastasis at Diagnosis
title_fullStr	Population-Based Survival Analysis of Patients With Limb Rhabdomyosarcoma and Metastasis at Diagnosis
title_full_unstemmed	Population-Based Survival Analysis of Patients With Limb Rhabdomyosarcoma and Metastasis at Diagnosis
title_sort	population-based survival analysis of patients with limb rhabdomyosarcoma and metastasis at diagnosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6362fc55b9204d448216e6dd3fcfcfba
work_keys_str_mv	AT chunyingyang populationbasedsurvivalanalysisofpatientswithlimbrhabdomyosarcomaandmetastasisatdiagnosis AT haiqingwang populationbasedsurvivalanalysisofpatientswithlimbrhabdomyosarcomaandmetastasisatdiagnosis AT fengniu populationbasedsurvivalanalysisofpatientswithlimbrhabdomyosarcomaandmetastasisatdiagnosis AT lufengyao populationbasedsurvivalanalysisofpatientswithlimbrhabdomyosarcomaandmetastasisatdiagnosis
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Population-Based Survival Analysis of Patients With Limb Rhabdomyosarcoma and Metastasis at Diagnosis

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