Antibiotic overuse in obstetric and gynecologic procedures at Zagazig university hospitals: A prospective observational study

Surgical site infection (SSI) constitutes a major problem in healthcare in terms of healthcare cost, morbidity and mortality. Surgical antibiotic prophylaxis (SAP) is one of the effective strategies for SSI prevention. Poor adherence to SAP guidelines across different countries has been observed. Mi...

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Autores principales:	Ahmed M. Magdy, Mahmoud A. Seksaka, Gehan F. Balata
Formato:	article
Lenguaje:	EN
Publicado:	Pensoft Publishers 2021
Materias:	Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/636365d987714865accb69eba4040334
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spelling	oai:doaj.org-article:636365d987714865accb69eba40403342021-11-24T04:31:03ZAntibiotic overuse in obstetric and gynecologic procedures at Zagazig university hospitals: A prospective observational study10.3897/pharmacia.68.e719232603-557Xhttps://doaj.org/article/636365d987714865accb69eba40403342021-11-01T00:00:00Zhttps://pharmacia.pensoft.net/article/71923/download/pdf/https://pharmacia.pensoft.net/article/71923/download/xml/https://pharmacia.pensoft.net/article/71923/https://doaj.org/toc/2603-557XSurgical site infection (SSI) constitutes a major problem in healthcare in terms of healthcare cost, morbidity and mortality. Surgical antibiotic prophylaxis (SAP) is one of the effective strategies for SSI prevention. Poor adherence to SAP guidelines across different countries has been observed. Misuse of prophylactic antibiotics threatens patient safety and leads to an increase in the acquisition of antibiotic resistance. The aim of this study was to assess the utilization of SAP in obstetric and gynecologic procedures in terms of indication for prophylaxis, antibiotic selection, timing of administration and prophylaxis duration. A prospective observational study was conducted at the obstetrics and gynecology department of Zagazig University Hospital during the period from January 2020 to June 2020. Medical records of 264 women were recorded and evaluated. The American Society of Health-System Pharmacists (ASHP) therapeutic guidelines, World Health Organization (WHO) recommendations and The American College of Obstetricians and Gynecologists (ACOG) practice bulletin were used for data evaluation and hence women were stratified into two groups. For women who underwent procedures in which guidelines recommended the use of SAP (200 patients; 75.75%), 198 women (99%) received preoperative prophylaxis. None of women (0%) received the recommended first line antibiotic by guidelines while the most commonly used prophylactic antibiotics were Cefotaxime (86 patients; 43.43%) and Ampicillin-sulbactam (62 patients; 31.31%). Preoperative antibiotic prophylaxis timing was 0-60 minutes before skin incision. All women received postoperative prophylaxis that extended to an average of 7 days. Regarding the other group who underwent procedures in which prophylactic antibiotics weren’t recommended by guidelines (64 patients; 24.24%), 37 women (57.81%) followed the guidelines and didn’t receive SAP while 27 women (42.18%) received SAP. Poor adherence to guidelines recommendations regarding prophylactic antibiotic selection and prophylaxis duration was observed. High utilization rate of prophylactic antibiotics in procedures that didn’t require their use was reported..Ahmed M. MagdyMahmoud A. SeksakaGehan F. BalataPensoft PublishersarticlePharmacy and materia medicaRS1-441ENPharmacia, Vol 68, Iss 4, Pp 883-889 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pharmacy and materia medica RS1-441
spellingShingle	Pharmacy and materia medica RS1-441 Ahmed M. Magdy Mahmoud A. Seksaka Gehan F. Balata Antibiotic overuse in obstetric and gynecologic procedures at Zagazig university hospitals: A prospective observational study
description	Surgical site infection (SSI) constitutes a major problem in healthcare in terms of healthcare cost, morbidity and mortality. Surgical antibiotic prophylaxis (SAP) is one of the effective strategies for SSI prevention. Poor adherence to SAP guidelines across different countries has been observed. Misuse of prophylactic antibiotics threatens patient safety and leads to an increase in the acquisition of antibiotic resistance. The aim of this study was to assess the utilization of SAP in obstetric and gynecologic procedures in terms of indication for prophylaxis, antibiotic selection, timing of administration and prophylaxis duration. A prospective observational study was conducted at the obstetrics and gynecology department of Zagazig University Hospital during the period from January 2020 to June 2020. Medical records of 264 women were recorded and evaluated. The American Society of Health-System Pharmacists (ASHP) therapeutic guidelines, World Health Organization (WHO) recommendations and The American College of Obstetricians and Gynecologists (ACOG) practice bulletin were used for data evaluation and hence women were stratified into two groups. For women who underwent procedures in which guidelines recommended the use of SAP (200 patients; 75.75%), 198 women (99%) received preoperative prophylaxis. None of women (0%) received the recommended first line antibiotic by guidelines while the most commonly used prophylactic antibiotics were Cefotaxime (86 patients; 43.43%) and Ampicillin-sulbactam (62 patients; 31.31%). Preoperative antibiotic prophylaxis timing was 0-60 minutes before skin incision. All women received postoperative prophylaxis that extended to an average of 7 days. Regarding the other group who underwent procedures in which prophylactic antibiotics weren’t recommended by guidelines (64 patients; 24.24%), 37 women (57.81%) followed the guidelines and didn’t receive SAP while 27 women (42.18%) received SAP. Poor adherence to guidelines recommendations regarding prophylactic antibiotic selection and prophylaxis duration was observed. High utilization rate of prophylactic antibiotics in procedures that didn’t require their use was reported..
format	article
author	Ahmed M. Magdy Mahmoud A. Seksaka Gehan F. Balata
author_facet	Ahmed M. Magdy Mahmoud A. Seksaka Gehan F. Balata
author_sort	Ahmed M. Magdy
title	Antibiotic overuse in obstetric and gynecologic procedures at Zagazig university hospitals: A prospective observational study
title_short	Antibiotic overuse in obstetric and gynecologic procedures at Zagazig university hospitals: A prospective observational study
title_full	Antibiotic overuse in obstetric and gynecologic procedures at Zagazig university hospitals: A prospective observational study
title_fullStr	Antibiotic overuse in obstetric and gynecologic procedures at Zagazig university hospitals: A prospective observational study
title_full_unstemmed	Antibiotic overuse in obstetric and gynecologic procedures at Zagazig university hospitals: A prospective observational study
title_sort	antibiotic overuse in obstetric and gynecologic procedures at zagazig university hospitals: a prospective observational study
publisher	Pensoft Publishers
publishDate	2021
url	https://doaj.org/article/636365d987714865accb69eba4040334
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_version_	1718415979022647296

Antibiotic overuse in obstetric and gynecologic procedures at Zagazig university hospitals: A prospective observational study

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