Refractory relapsing polychondritis: challenges and solutions

Fernando Kemta Lekpa,1,2 Xavier Chevalier3 1Faculty of Health Sciences, University of Buea, Buea, 2Reheumatology Unit, Internal Medicine Department, General Hospital, Douala, Cameroon; 3Department of Rheumatology, Henri Mondor Hospital, University Paris 12, Créteil, France Abstract: Relap...

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Autores principales: Kemta Lekpa F, Chevalier X
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Publicado: Dove Medical Press 2018
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spelling oai:doaj.org-article:63677202d3d6433b817746197d7efcc52021-12-02T07:43:48ZRefractory relapsing polychondritis: challenges and solutions1179-156Xhttps://doaj.org/article/63677202d3d6433b817746197d7efcc52018-01-01T00:00:00Zhttps://www.dovepress.com/refractory-relapsing-polychondritis-challenges-and-solutions-peer-reviewed-article-OARRRhttps://doaj.org/toc/1179-156XFernando Kemta Lekpa,1,2 Xavier Chevalier3 1Faculty of Health Sciences, University of Buea, Buea, 2Reheumatology Unit, Internal Medicine Department, General Hospital, Douala, Cameroon; 3Department of Rheumatology, Henri Mondor Hospital, University Paris 12, Créteil, France Abstract: Relapsing polychondritis is a severe systemic immune-mediated disease characterized by an episodic and progressive inflammatory condition with progressive destruction of cartilaginous structures. This disease has for nearly a century kept secrets not yet explained. The real incidence and prevalence of this rare disease are unknown. The multiple clinical presentations and episodic nature of relapsing polychondritis cause a significant diagnosis delay. No guidelines for the management of patients with relapsing polychondritis have been validated to date. The challenges remain, both in the understanding of its pathophysiology and diagnosis, evaluation of its activity and prognosis, and its treatment. Possible solutions involve the sharing of data for relapsing polychondritis from worldwide reference centers. Thus, we would be able to evolve toward a better knowledge of its pathophysiology, the publication of new diagnosis criteria, which will include biological markers and imaging findings, the prediction of life-threatening or organ-threatening situations, and the publication of therapeutic evidence-based guidelines after performing at randomized controlled trials. Keywords: relapsing polychondritis, diagnosis, criteria, disease activity, treatments, biologicsKemta Lekpa FChevalier XDove Medical PressarticleRelapsing polychondritisDiagnosisCriteriaDisease activityBiologicsDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 10, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Relapsing polychondritis
Diagnosis
Criteria
Disease activity
Biologics
Diseases of the musculoskeletal system
RC925-935
spellingShingle Relapsing polychondritis
Diagnosis
Criteria
Disease activity
Biologics
Diseases of the musculoskeletal system
RC925-935
Kemta Lekpa F
Chevalier X
Refractory relapsing polychondritis: challenges and solutions
description Fernando Kemta Lekpa,1,2 Xavier Chevalier3 1Faculty of Health Sciences, University of Buea, Buea, 2Reheumatology Unit, Internal Medicine Department, General Hospital, Douala, Cameroon; 3Department of Rheumatology, Henri Mondor Hospital, University Paris 12, Créteil, France Abstract: Relapsing polychondritis is a severe systemic immune-mediated disease characterized by an episodic and progressive inflammatory condition with progressive destruction of cartilaginous structures. This disease has for nearly a century kept secrets not yet explained. The real incidence and prevalence of this rare disease are unknown. The multiple clinical presentations and episodic nature of relapsing polychondritis cause a significant diagnosis delay. No guidelines for the management of patients with relapsing polychondritis have been validated to date. The challenges remain, both in the understanding of its pathophysiology and diagnosis, evaluation of its activity and prognosis, and its treatment. Possible solutions involve the sharing of data for relapsing polychondritis from worldwide reference centers. Thus, we would be able to evolve toward a better knowledge of its pathophysiology, the publication of new diagnosis criteria, which will include biological markers and imaging findings, the prediction of life-threatening or organ-threatening situations, and the publication of therapeutic evidence-based guidelines after performing at randomized controlled trials. Keywords: relapsing polychondritis, diagnosis, criteria, disease activity, treatments, biologics
format article
author Kemta Lekpa F
Chevalier X
author_facet Kemta Lekpa F
Chevalier X
author_sort Kemta Lekpa F
title Refractory relapsing polychondritis: challenges and solutions
title_short Refractory relapsing polychondritis: challenges and solutions
title_full Refractory relapsing polychondritis: challenges and solutions
title_fullStr Refractory relapsing polychondritis: challenges and solutions
title_full_unstemmed Refractory relapsing polychondritis: challenges and solutions
title_sort refractory relapsing polychondritis: challenges and solutions
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/63677202d3d6433b817746197d7efcc5
work_keys_str_mv AT kemtalekpaf refractoryrelapsingpolychondritischallengesandsolutions
AT chevalierx refractoryrelapsingpolychondritischallengesandsolutions
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