The effect of remdesivir on selective biomarkers and its value in predicting the clinical outcome in patients with COVID-19
Background: To the best of our knowledge, there have been no studies to evaluate the effect of remdesivir on inflammatory markers. Aims and Objectives: To study the effect of Remdesivir on Selective biomarkers namely C-Reactive Protein (CRP), Lactate Dehydrogenase (LDH), Serum Ferritin and D-dime...
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Manipal College of Medical Sciences, Pokhara
2021
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| Acceso en línea: | https://doi.org/10.3126/ajms.v12i12.39164 https://doaj.org/article/6369f38059fd495da1336e9cb1774f9c |
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oai:doaj.org-article:6369f38059fd495da1336e9cb1774f9c2021-12-01T11:05:10ZThe effect of remdesivir on selective biomarkers and its value in predicting the clinical outcome in patients with COVID-19https://doi.org/10.3126/ajms.v12i12.391642467-91002091-0576https://doaj.org/article/6369f38059fd495da1336e9cb1774f9c2021-12-01T00:00:00Zhttps://www.nepjol.info/index.php/AJMS/article/view/39164https://doaj.org/toc/2467-9100https://doaj.org/toc/2091-0576Background: To the best of our knowledge, there have been no studies to evaluate the effect of remdesivir on inflammatory markers. Aims and Objectives: To study the effect of Remdesivir on Selective biomarkers namely C-Reactive Protein (CRP), Lactate Dehydrogenase (LDH), Serum Ferritin and D-dimer and their value in predicting the clinical outcome in patients with COVID -19 infection. Materials and Methods: This is a retrospective observational study including 102 laboratory-confirmed COVID-19 patients of moderate and severe category who were subjected to complete blood count, liver function test, BUN, creatinine, C-reactive protein, lactate dehydrogenase, D-dimer, serum ferritin, ECG, and chest X-ray. The association was analyzed using independent sample t-test or Mann–Whitney U-test. Patients were divided into two groups. Both received corticosteroids and anticoagulants. Group A also received remdesivir. Results: Of the 102 patients, 90.2% of the patients in the non-remdesivir group and 94.1% in the remdesivir group were discharged. The mortality rate was 9.8% in the non-remdesivir group versus 5.9% in the remdesivir group (P=0.71). There was no statistically significant difference in the decrease of the inflammatory markers overtime in both the groups, irrespective of whether they received remdesivir or not. Conclusion: High values of the inflammatory markers were seen at the time of admission. A 5 days course of remdesivir failed to demonstrate a statistically significant difference in the decrease in the levels of the inflammatory markers. However, we have observed a possible clinical benefit of remdesivir among patients with moderate and severe COVID-19 disease, as there was a trend toward better clinical outcomes. Further studies are needed to evaluate this therapeutic strategy.Sanjana Rai Dyna Jones Chinnappa Anjanappa Jayashankar Venkata Bharat Kumar Pinnelli Eashwer Manpreeth Venkata Sai Raghava Prashanthi Seetha Manipal College of Medical Sciences, Pokharaarticlecovid-19 infectionc-reactive proteind-dimerferritininflammatory markerslactate dehydrogenaseremdesivirMedicineRENAsian Journal of Medical Sciences, Vol 12, Iss 12, Pp 3-8 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
covid-19 infection c-reactive protein d-dimer ferritin inflammatory markers lactate dehydrogenase remdesivir Medicine R |
| spellingShingle |
covid-19 infection c-reactive protein d-dimer ferritin inflammatory markers lactate dehydrogenase remdesivir Medicine R Sanjana Rai Dyna Jones Chinnappa Anjanappa Jayashankar Venkata Bharat Kumar Pinnelli Eashwer Manpreeth Venkata Sai Raghava Prashanthi Seetha The effect of remdesivir on selective biomarkers and its value in predicting the clinical outcome in patients with COVID-19 |
| description |
Background: To the best of our knowledge, there have been no studies to evaluate the effect of remdesivir on inflammatory markers.
Aims and Objectives: To study the effect of Remdesivir on Selective biomarkers namely C-Reactive Protein (CRP), Lactate Dehydrogenase (LDH), Serum Ferritin and D-dimer and their value in predicting the clinical outcome in patients with COVID -19 infection.
Materials and Methods: This is a retrospective observational study including 102 laboratory-confirmed COVID-19 patients of moderate and severe category who were subjected to complete blood count, liver function test, BUN, creatinine, C-reactive protein, lactate dehydrogenase, D-dimer, serum ferritin, ECG, and chest X-ray. The association was analyzed using independent sample t-test or Mann–Whitney U-test. Patients were divided into two groups. Both received corticosteroids and anticoagulants. Group A also received remdesivir.
Results: Of the 102 patients, 90.2% of the patients in the non-remdesivir group and 94.1% in the remdesivir group were discharged. The mortality rate was 9.8% in the non-remdesivir group versus 5.9% in the remdesivir group (P=0.71). There was no statistically significant difference in the decrease of the inflammatory markers overtime in both the groups, irrespective of whether they received remdesivir or not.
Conclusion: High values of the inflammatory markers were seen at the time of admission. A 5 days course of remdesivir failed to demonstrate a statistically significant difference in the decrease in the levels of the inflammatory markers. However, we have observed a possible clinical benefit of remdesivir among patients with moderate and severe COVID-19 disease, as there was a trend toward better clinical outcomes. Further studies are needed to evaluate this therapeutic strategy. |
| format |
article |
| author |
Sanjana Rai Dyna Jones Chinnappa Anjanappa Jayashankar Venkata Bharat Kumar Pinnelli Eashwer Manpreeth Venkata Sai Raghava Prashanthi Seetha |
| author_facet |
Sanjana Rai Dyna Jones Chinnappa Anjanappa Jayashankar Venkata Bharat Kumar Pinnelli Eashwer Manpreeth Venkata Sai Raghava Prashanthi Seetha |
| author_sort |
Sanjana Rai |
| title |
The effect of remdesivir on selective biomarkers and its value in predicting the clinical outcome in patients with COVID-19 |
| title_short |
The effect of remdesivir on selective biomarkers and its value in predicting the clinical outcome in patients with COVID-19 |
| title_full |
The effect of remdesivir on selective biomarkers and its value in predicting the clinical outcome in patients with COVID-19 |
| title_fullStr |
The effect of remdesivir on selective biomarkers and its value in predicting the clinical outcome in patients with COVID-19 |
| title_full_unstemmed |
The effect of remdesivir on selective biomarkers and its value in predicting the clinical outcome in patients with COVID-19 |
| title_sort |
effect of remdesivir on selective biomarkers and its value in predicting the clinical outcome in patients with covid-19 |
| publisher |
Manipal College of Medical Sciences, Pokhara |
| publishDate |
2021 |
| url |
https://doi.org/10.3126/ajms.v12i12.39164 https://doaj.org/article/6369f38059fd495da1336e9cb1774f9c |
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