Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents

Radiation damage causes DNA foci to form and senescence, causing ulcers. Here, the authors show that a naturally occurring adenosine analogue, cordycepin, prevents cell senescence via an increase in AMPK/NRF2, so blocking ulcers caused by radiation on skin/intestine/tongue damage in rodents.

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Autores principales:	Ziwen Wang, Zelin Chen, Zhongyong Jiang, Peng Luo, Lang Liu, Yu Huang, Huilan Wang, Yu Wang, Lei Long, Xu Tan, Dengqun Liu, Taotao Jin, Yawei Wang, Yang Wang, Fengying Liao, Chi Zhang, Long Chen, Yibo Gan, Yunsheng Liu, Fan Yang, Chunji Huang, Hongming Miao, Jieping Chen, Tianmin Cheng, Xiaobing Fu, Chunmeng Shi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6374e26fa7c444b6a818405012349c34
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spelling	oai:doaj.org-article:6374e26fa7c444b6a818405012349c342021-12-02T15:35:50ZCordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents10.1038/s41467-019-10386-82041-1723https://doaj.org/article/6374e26fa7c444b6a818405012349c342019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10386-8https://doaj.org/toc/2041-1723Radiation damage causes DNA foci to form and senescence, causing ulcers. Here, the authors show that a naturally occurring adenosine analogue, cordycepin, prevents cell senescence via an increase in AMPK/NRF2, so blocking ulcers caused by radiation on skin/intestine/tongue damage in rodents.Ziwen WangZelin ChenZhongyong JiangPeng LuoLang LiuYu HuangHuilan WangYu WangLei LongXu TanDengqun LiuTaotao JinYawei WangYang WangFengying LiaoChi ZhangLong ChenYibo GanYunsheng LiuFan YangChunji HuangHongming MiaoJieping ChenTianmin ChengXiaobing FuChunmeng ShiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ziwen Wang Zelin Chen Zhongyong Jiang Peng Luo Lang Liu Yu Huang Huilan Wang Yu Wang Lei Long Xu Tan Dengqun Liu Taotao Jin Yawei Wang Yang Wang Fengying Liao Chi Zhang Long Chen Yibo Gan Yunsheng Liu Fan Yang Chunji Huang Hongming Miao Jieping Chen Tianmin Cheng Xiaobing Fu Chunmeng Shi Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents
description	Radiation damage causes DNA foci to form and senescence, causing ulcers. Here, the authors show that a naturally occurring adenosine analogue, cordycepin, prevents cell senescence via an increase in AMPK/NRF2, so blocking ulcers caused by radiation on skin/intestine/tongue damage in rodents.
format	article
author	Ziwen Wang Zelin Chen Zhongyong Jiang Peng Luo Lang Liu Yu Huang Huilan Wang Yu Wang Lei Long Xu Tan Dengqun Liu Taotao Jin Yawei Wang Yang Wang Fengying Liao Chi Zhang Long Chen Yibo Gan Yunsheng Liu Fan Yang Chunji Huang Hongming Miao Jieping Chen Tianmin Cheng Xiaobing Fu Chunmeng Shi
author_facet	Ziwen Wang Zelin Chen Zhongyong Jiang Peng Luo Lang Liu Yu Huang Huilan Wang Yu Wang Lei Long Xu Tan Dengqun Liu Taotao Jin Yawei Wang Yang Wang Fengying Liao Chi Zhang Long Chen Yibo Gan Yunsheng Liu Fan Yang Chunji Huang Hongming Miao Jieping Chen Tianmin Cheng Xiaobing Fu Chunmeng Shi
author_sort	Ziwen Wang
title	Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents
title_short	Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents
title_full	Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents
title_fullStr	Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents
title_full_unstemmed	Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents
title_sort	cordycepin prevents radiation ulcer by inhibiting cell senescence via nrf2 and ampk in rodents
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6374e26fa7c444b6a818405012349c34
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Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents

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