Transmission dynamics of methicillin-resistant Staphylococcus aureus in a medical intensive care unit in India.

<h4>Background</h4>Methicillin-resistant Staphylococcus aureus (MRSA) is a global pathogen and an important but seldom investigated cause of morbidity and mortality in lower and middle-income countries where it can place a major burden on limited resources. Quantifying nosocomial transmi...

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Autores principales:	Solomon Christopher, Rejina Mariam Verghis, Belavendra Antonisamy, Thuppal Varadachari Sowmyanarayanan, Kootallur Narayanan Brahmadathan, Gagandeep Kang, Ben Symons Cooper
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/63791a51a05b4abfb5ad59523617a166
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spelling	oai:doaj.org-article:63791a51a05b4abfb5ad59523617a1662021-11-18T06:50:46ZTransmission dynamics of methicillin-resistant Staphylococcus aureus in a medical intensive care unit in India.1932-620310.1371/journal.pone.0020604https://doaj.org/article/63791a51a05b4abfb5ad59523617a1662011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21750700/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Methicillin-resistant Staphylococcus aureus (MRSA) is a global pathogen and an important but seldom investigated cause of morbidity and mortality in lower and middle-income countries where it can place a major burden on limited resources. Quantifying nosocomial transmission in resource-poor settings is difficult because molecular typing methods are prohibitively expensive. Mechanistic statistical models can overcome this problem with minimal cost. We analyse the transmission dynamics of MRSA in a hospital in south India using one such approach and provide conservative estimates of the organism's economic burden.<h4>Methods and findings</h4>Fifty months of MRSA infection data were collected retrospectively from a Medical Intensive Care Unit (MICU) in a tertiary hospital in Vellore, south India. Data were analysed using a previously described structured hidden Markov model. Seventy-two patients developed MRSA infections and, of these, 49 (68%) died in the MICU. We estimated that 4.2% (95%CI 1.0, 19.0) of patients were MRSA-positive when admitted, that there were 0.39 MRSA infections per colonized patient month (0.06, 0.73), and that the ward-level reproduction number for MRSA was 0.42 (0.08, 2.04). Anti-MRSA antibiotic treatment costs alone averaged $124/patient, over three times the monthly income of more than 40% of the Indian population.<h4>Conclusions</h4>Our analysis of routine data provides the first estimate of the nosocomial transmission potential of MRSA in India. The high levels of transmission estimated underline the need for cost-effective interventions to reduce MRSA transmission in hospital settings in low and middle income countries.Solomon ChristopherRejina Mariam VerghisBelavendra AntonisamyThuppal Varadachari SowmyanarayananKootallur Narayanan BrahmadathanGagandeep KangBen Symons CooperPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e20604 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Solomon Christopher Rejina Mariam Verghis Belavendra Antonisamy Thuppal Varadachari Sowmyanarayanan Kootallur Narayanan Brahmadathan Gagandeep Kang Ben Symons Cooper Transmission dynamics of methicillin-resistant Staphylococcus aureus in a medical intensive care unit in India.
description	<h4>Background</h4>Methicillin-resistant Staphylococcus aureus (MRSA) is a global pathogen and an important but seldom investigated cause of morbidity and mortality in lower and middle-income countries where it can place a major burden on limited resources. Quantifying nosocomial transmission in resource-poor settings is difficult because molecular typing methods are prohibitively expensive. Mechanistic statistical models can overcome this problem with minimal cost. We analyse the transmission dynamics of MRSA in a hospital in south India using one such approach and provide conservative estimates of the organism's economic burden.<h4>Methods and findings</h4>Fifty months of MRSA infection data were collected retrospectively from a Medical Intensive Care Unit (MICU) in a tertiary hospital in Vellore, south India. Data were analysed using a previously described structured hidden Markov model. Seventy-two patients developed MRSA infections and, of these, 49 (68%) died in the MICU. We estimated that 4.2% (95%CI 1.0, 19.0) of patients were MRSA-positive when admitted, that there were 0.39 MRSA infections per colonized patient month (0.06, 0.73), and that the ward-level reproduction number for MRSA was 0.42 (0.08, 2.04). Anti-MRSA antibiotic treatment costs alone averaged $124/patient, over three times the monthly income of more than 40% of the Indian population.<h4>Conclusions</h4>Our analysis of routine data provides the first estimate of the nosocomial transmission potential of MRSA in India. The high levels of transmission estimated underline the need for cost-effective interventions to reduce MRSA transmission in hospital settings in low and middle income countries.
format	article
author	Solomon Christopher Rejina Mariam Verghis Belavendra Antonisamy Thuppal Varadachari Sowmyanarayanan Kootallur Narayanan Brahmadathan Gagandeep Kang Ben Symons Cooper
author_facet	Solomon Christopher Rejina Mariam Verghis Belavendra Antonisamy Thuppal Varadachari Sowmyanarayanan Kootallur Narayanan Brahmadathan Gagandeep Kang Ben Symons Cooper
author_sort	Solomon Christopher
title	Transmission dynamics of methicillin-resistant Staphylococcus aureus in a medical intensive care unit in India.
title_short	Transmission dynamics of methicillin-resistant Staphylococcus aureus in a medical intensive care unit in India.
title_full	Transmission dynamics of methicillin-resistant Staphylococcus aureus in a medical intensive care unit in India.
title_fullStr	Transmission dynamics of methicillin-resistant Staphylococcus aureus in a medical intensive care unit in India.
title_full_unstemmed	Transmission dynamics of methicillin-resistant Staphylococcus aureus in a medical intensive care unit in India.
title_sort	transmission dynamics of methicillin-resistant staphylococcus aureus in a medical intensive care unit in india.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/63791a51a05b4abfb5ad59523617a166
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Transmission dynamics of methicillin-resistant Staphylococcus aureus in a medical intensive care unit in India.

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