Oocyte-derived microvilli control female fertility by optimizing ovarian follicle selection in mice

How structural features on oocytes regulate mammalian female reproduction is unclear. Here, the authors provide imaging and physiological evidence (for example on Radixin knockout) to identify oocyte-derived mushroom-like microvilli that control the female reproductive lifespan by governing the fate...

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Autores principales: Yan Zhang, Ye Wang, Xie’an Feng, Shuo Zhang, Xueqiang Xu, Lingyu Li, Shudong Niu, Yingnan Bo, Chao Wang, Zhen Li, Guoliang Xia, Hua Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/638000cff18441019437acafe4c03b06
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Sumario:How structural features on oocytes regulate mammalian female reproduction is unclear. Here, the authors provide imaging and physiological evidence (for example on Radixin knockout) to identify oocyte-derived mushroom-like microvilli that control the female reproductive lifespan by governing the fate of follicles.