NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation

NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation

BRCA1 mutation carriers have higher chances of developing triple-negative breast cancer (TNBC). Here, the authors use the Sleeping Beauty mutagenesis system in Brca1 deficient mice and identify 169 putative driver genes, of which NOTCH1 accelerates TNBC formation through promoting epithelial-mesench...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Kai Miao, Josh Haipeng Lei, Monica Vishnu Valecha, Aiping Zhang, Jun Xu, Lijian Wang, Xueying Lyu, Si Chen, Zhengqiang Miao, Xin Zhang, Sek Man Su, Fangyuan Shao, Barani Kumar Rajendran, Jiaolin Bao, Jianming Zeng, Heng Sun, Ping Chen, Kaeling Tan, Qiang Chen, Koon Ho Wong, Xiaoling Xu, Chu-Xia Deng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/638072c49e054dab8744a620ce85ebc9
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:BRCA1 mutation carriers have higher chances of developing triple-negative breast cancer (TNBC). Here, the authors use the Sleeping Beauty mutagenesis system in Brca1 deficient mice and identify 169 putative driver genes, of which NOTCH1 accelerates TNBC formation through promoting epithelial-mesenchymal transition and cell cycle progression.

Ejemplares similares