NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation

BRCA1 mutation carriers have higher chances of developing triple-negative breast cancer (TNBC). Here, the authors use the Sleeping Beauty mutagenesis system in Brca1 deficient mice and identify 169 putative driver genes, of which NOTCH1 accelerates TNBC formation through promoting epithelial-mesench...

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Autores principales:	Kai Miao, Josh Haipeng Lei, Monica Vishnu Valecha, Aiping Zhang, Jun Xu, Lijian Wang, Xueying Lyu, Si Chen, Zhengqiang Miao, Xin Zhang, Sek Man Su, Fangyuan Shao, Barani Kumar Rajendran, Jiaolin Bao, Jianming Zeng, Heng Sun, Ping Chen, Kaeling Tan, Qiang Chen, Koon Ho Wong, Xiaoling Xu, Chu-Xia Deng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/638072c49e054dab8744a620ce85ebc9
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spelling	oai:doaj.org-article:638072c49e054dab8744a620ce85ebc92021-12-02T17:45:10ZNOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation10.1038/s41467-020-16936-92041-1723https://doaj.org/article/638072c49e054dab8744a620ce85ebc92020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16936-9https://doaj.org/toc/2041-1723BRCA1 mutation carriers have higher chances of developing triple-negative breast cancer (TNBC). Here, the authors use the Sleeping Beauty mutagenesis system in Brca1 deficient mice and identify 169 putative driver genes, of which NOTCH1 accelerates TNBC formation through promoting epithelial-mesenchymal transition and cell cycle progression.Kai MiaoJosh Haipeng LeiMonica Vishnu ValechaAiping ZhangJun XuLijian WangXueying LyuSi ChenZhengqiang MiaoXin ZhangSek Man SuFangyuan ShaoBarani Kumar RajendranJiaolin BaoJianming ZengHeng SunPing ChenKaeling TanQiang ChenKoon Ho WongXiaoling XuChu-Xia DengNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kai Miao Josh Haipeng Lei Monica Vishnu Valecha Aiping Zhang Jun Xu Lijian Wang Xueying Lyu Si Chen Zhengqiang Miao Xin Zhang Sek Man Su Fangyuan Shao Barani Kumar Rajendran Jiaolin Bao Jianming Zeng Heng Sun Ping Chen Kaeling Tan Qiang Chen Koon Ho Wong Xiaoling Xu Chu-Xia Deng NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation
description	BRCA1 mutation carriers have higher chances of developing triple-negative breast cancer (TNBC). Here, the authors use the Sleeping Beauty mutagenesis system in Brca1 deficient mice and identify 169 putative driver genes, of which NOTCH1 accelerates TNBC formation through promoting epithelial-mesenchymal transition and cell cycle progression.
format	article
author	Kai Miao Josh Haipeng Lei Monica Vishnu Valecha Aiping Zhang Jun Xu Lijian Wang Xueying Lyu Si Chen Zhengqiang Miao Xin Zhang Sek Man Su Fangyuan Shao Barani Kumar Rajendran Jiaolin Bao Jianming Zeng Heng Sun Ping Chen Kaeling Tan Qiang Chen Koon Ho Wong Xiaoling Xu Chu-Xia Deng
author_facet	Kai Miao Josh Haipeng Lei Monica Vishnu Valecha Aiping Zhang Jun Xu Lijian Wang Xueying Lyu Si Chen Zhengqiang Miao Xin Zhang Sek Man Su Fangyuan Shao Barani Kumar Rajendran Jiaolin Bao Jianming Zeng Heng Sun Ping Chen Kaeling Tan Qiang Chen Koon Ho Wong Xiaoling Xu Chu-Xia Deng
author_sort	Kai Miao
title	NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation
title_short	NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation
title_full	NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation
title_fullStr	NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation
title_full_unstemmed	NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation
title_sort	notch1 activation compensates brca1 deficiency and promotes triple-negative breast cancer formation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/638072c49e054dab8744a620ce85ebc9
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NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation

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