The activation of PPARγ by 2,4,6-Octatrienoic acid protects human keratinocytes from UVR-induced damages

Abstract Increasing attention is addressed to identify products able to enhance skin photoprotection and to prevent skin carcinogenesis. Several studies have demonstrated that the α-melanocyte stimulating hormone (αMSH), acting on a functional MC1R, provides a photoprotective effect by inducing pigm...

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Autores principales:	Enrica Flori, Arianna Mastrofrancesco, Daniela Kovacs, Barbara Bellei, Stefania Briganti, Vittoria Maresca, Giorgia Cardinali, Mauro Picardo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/63811ae9102244098bb9b2a2d39ac52e
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spelling	oai:doaj.org-article:63811ae9102244098bb9b2a2d39ac52e2021-12-02T16:06:59ZThe activation of PPARγ by 2,4,6-Octatrienoic acid protects human keratinocytes from UVR-induced damages10.1038/s41598-017-09578-32045-2322https://doaj.org/article/63811ae9102244098bb9b2a2d39ac52e2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09578-3https://doaj.org/toc/2045-2322Abstract Increasing attention is addressed to identify products able to enhance skin photoprotection and to prevent skin carcinogenesis. Several studies have demonstrated that the α-melanocyte stimulating hormone (αMSH), acting on a functional MC1R, provides a photoprotective effect by inducing pigmentation, antioxidants and DNA repair. We discovered a link between αMSH and the nuclear receptor Peroxisome Proliferator-Activated Receptor-γ (PPARγ), suggesting that some of the αMSH protective effects may be dependent on PPARγ transcriptional activity. Moreover, we demonstrated that the activation of PPARγ by the parrodiene 2,4,6-octatrienoic acid (Octa) induces melanogenesis and antioxidant defence in human melanocytes and counteracts senescence-like phenotype in human fibroblasts. In this study, we demonstrate that the activation of PPARγ by Octa exerts a protective effect against UVA- and UVB-induced damage on normal human keratinocytes (NHKs), the major target cells of UV radiation. Octa promotes the antioxidant defence, augments DNA repair and reduces the induction of proteins involved in UV-induced DNA damage response. Our results contribute to deepen the analysis of the αMSH/PPARγ connection and suggest perspectives for the development of new molecules and formulations able to prevent cutaneous UV damage by acting on the different skin cell populations through PPARγ activation.Enrica FloriArianna MastrofrancescoDaniela KovacsBarbara BelleiStefania BrigantiVittoria MarescaGiorgia CardinaliMauro PicardoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Enrica Flori Arianna Mastrofrancesco Daniela Kovacs Barbara Bellei Stefania Briganti Vittoria Maresca Giorgia Cardinali Mauro Picardo The activation of PPARγ by 2,4,6-Octatrienoic acid protects human keratinocytes from UVR-induced damages
description	Abstract Increasing attention is addressed to identify products able to enhance skin photoprotection and to prevent skin carcinogenesis. Several studies have demonstrated that the α-melanocyte stimulating hormone (αMSH), acting on a functional MC1R, provides a photoprotective effect by inducing pigmentation, antioxidants and DNA repair. We discovered a link between αMSH and the nuclear receptor Peroxisome Proliferator-Activated Receptor-γ (PPARγ), suggesting that some of the αMSH protective effects may be dependent on PPARγ transcriptional activity. Moreover, we demonstrated that the activation of PPARγ by the parrodiene 2,4,6-octatrienoic acid (Octa) induces melanogenesis and antioxidant defence in human melanocytes and counteracts senescence-like phenotype in human fibroblasts. In this study, we demonstrate that the activation of PPARγ by Octa exerts a protective effect against UVA- and UVB-induced damage on normal human keratinocytes (NHKs), the major target cells of UV radiation. Octa promotes the antioxidant defence, augments DNA repair and reduces the induction of proteins involved in UV-induced DNA damage response. Our results contribute to deepen the analysis of the αMSH/PPARγ connection and suggest perspectives for the development of new molecules and formulations able to prevent cutaneous UV damage by acting on the different skin cell populations through PPARγ activation.
format	article
author	Enrica Flori Arianna Mastrofrancesco Daniela Kovacs Barbara Bellei Stefania Briganti Vittoria Maresca Giorgia Cardinali Mauro Picardo
author_facet	Enrica Flori Arianna Mastrofrancesco Daniela Kovacs Barbara Bellei Stefania Briganti Vittoria Maresca Giorgia Cardinali Mauro Picardo
author_sort	Enrica Flori
title	The activation of PPARγ by 2,4,6-Octatrienoic acid protects human keratinocytes from UVR-induced damages
title_short	The activation of PPARγ by 2,4,6-Octatrienoic acid protects human keratinocytes from UVR-induced damages
title_full	The activation of PPARγ by 2,4,6-Octatrienoic acid protects human keratinocytes from UVR-induced damages
title_fullStr	The activation of PPARγ by 2,4,6-Octatrienoic acid protects human keratinocytes from UVR-induced damages
title_full_unstemmed	The activation of PPARγ by 2,4,6-Octatrienoic acid protects human keratinocytes from UVR-induced damages
title_sort	activation of pparγ by 2,4,6-octatrienoic acid protects human keratinocytes from uvr-induced damages
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/63811ae9102244098bb9b2a2d39ac52e
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The activation of PPARγ by 2,4,6-Octatrienoic acid protects human keratinocytes from UVR-induced damages

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