Clinical, optical coherence tomography, and fundus autofluorescence findings in patients with intraocular tumors

Daniel Samuelsson, Monika Sznage, Karl Engelsberg, Elisabeth Wittström Department of Ophthalmology, Lund University, Skane University Hospital, Lund, Sweden Purpose: To describe clinical, optical coherence tomography (OCT) and fundus autofluorescence (FAF) findings in patients with intrao...

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Autores principales:	Samuelsson D, Sznage M, Engelsberg K, Wittström E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Intraocular tumors optical coherence tomography fundus autofluorescence tumor growth Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/6382f40351994382a4f0810864c17dec
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spelling	oai:doaj.org-article:6382f40351994382a4f0810864c17dec2021-12-02T03:26:48ZClinical, optical coherence tomography, and fundus autofluorescence findings in patients with intraocular tumors1177-5483https://doaj.org/article/6382f40351994382a4f0810864c17dec2016-10-01T00:00:00Zhttps://www.dovepress.com/clinical-optical-coherence-tomography-and-fundus-autofluorescence-find-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Daniel Samuelsson, Monika Sznage, Karl Engelsberg, Elisabeth Wittström Department of Ophthalmology, Lund University, Skane University Hospital, Lund, Sweden Purpose: To describe clinical, optical coherence tomography (OCT) and fundus autofluorescence (FAF) findings in patients with intraocular tumors and determine if OCT and FAF could be helpful in the differential diagnosis and management of different choroidal tumors. Methods: Forty-nine patients with untreated, macular, midperipheral, and extrapapillary intraocular tumors were included. All patients underwent ophthalmic examination: best-corrected visual acuity, slit-lamp biomicroscopy, funduscopy, and standardized B mode, and if possible A mode, ultrasonography, and OCT and FAF imaging of the surface of the intraocular tumors. Results: Of the 49 patients studied, 19 had choroidal nevi, ten had indeterminate choroidal melanocytic lesions (IMLs), ten had malignant melanomas, and ten had other choroidal tumors. The choroidal nevi revealed subretinal fluid (SRF) on OCT in only 11%. FAF detected isoautofluorescence in 42%, hypoautofluorescence in 37%, patchy FAF pattern in 16%, and a diffuse FAF pattern in 5%. Seventy percent of patients with IML showed SRF on OCT and 20% showed tumor growth on follow-up, detected only by OCT and FAF imaging. FAF revealed a patchy pattern in 50% and a diffuse pattern in 40% of cases with IML. Ninety percent of the patients with choroidal melanoma had SRF on OCT and FAF revealed a patchy pattern in 60% and a diffuse pattern in 40%. Patients with other choroidal tumors had SRF on OCT in 30% of cases and no characteristic pattern on FAF. Conclusion: Both OCT and FAF were helpful in the differential diagnosis of choroidal nevi versus IMLs, choroidal melanomas, and other choroidal tumors. Also, detailed and periodical clinical evaluation of patients with intraocular tumors using OCT and FAF imaging for the detection of both SRF and FAF patterns overlying the tumor can be useful for detection of tumor growth. Keywords: intraocular tumors, optical coherence tomography, fundus autofluorescence, tumor growthSamuelsson DSznage MEngelsberg KWittström EDove Medical PressarticleIntraocular tumorsoptical coherence tomographyfundus autofluorescencetumor growthOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 10, Pp 1953-1964 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Intraocular tumors optical coherence tomography fundus autofluorescence tumor growth Ophthalmology RE1-994
spellingShingle	Intraocular tumors optical coherence tomography fundus autofluorescence tumor growth Ophthalmology RE1-994 Samuelsson D Sznage M Engelsberg K Wittström E Clinical, optical coherence tomography, and fundus autofluorescence findings in patients with intraocular tumors
description	Daniel Samuelsson, Monika Sznage, Karl Engelsberg, Elisabeth Wittström Department of Ophthalmology, Lund University, Skane University Hospital, Lund, Sweden Purpose: To describe clinical, optical coherence tomography (OCT) and fundus autofluorescence (FAF) findings in patients with intraocular tumors and determine if OCT and FAF could be helpful in the differential diagnosis and management of different choroidal tumors. Methods: Forty-nine patients with untreated, macular, midperipheral, and extrapapillary intraocular tumors were included. All patients underwent ophthalmic examination: best-corrected visual acuity, slit-lamp biomicroscopy, funduscopy, and standardized B mode, and if possible A mode, ultrasonography, and OCT and FAF imaging of the surface of the intraocular tumors. Results: Of the 49 patients studied, 19 had choroidal nevi, ten had indeterminate choroidal melanocytic lesions (IMLs), ten had malignant melanomas, and ten had other choroidal tumors. The choroidal nevi revealed subretinal fluid (SRF) on OCT in only 11%. FAF detected isoautofluorescence in 42%, hypoautofluorescence in 37%, patchy FAF pattern in 16%, and a diffuse FAF pattern in 5%. Seventy percent of patients with IML showed SRF on OCT and 20% showed tumor growth on follow-up, detected only by OCT and FAF imaging. FAF revealed a patchy pattern in 50% and a diffuse pattern in 40% of cases with IML. Ninety percent of the patients with choroidal melanoma had SRF on OCT and FAF revealed a patchy pattern in 60% and a diffuse pattern in 40%. Patients with other choroidal tumors had SRF on OCT in 30% of cases and no characteristic pattern on FAF. Conclusion: Both OCT and FAF were helpful in the differential diagnosis of choroidal nevi versus IMLs, choroidal melanomas, and other choroidal tumors. Also, detailed and periodical clinical evaluation of patients with intraocular tumors using OCT and FAF imaging for the detection of both SRF and FAF patterns overlying the tumor can be useful for detection of tumor growth. Keywords: intraocular tumors, optical coherence tomography, fundus autofluorescence, tumor growth
format	article
author	Samuelsson D Sznage M Engelsberg K Wittström E
author_facet	Samuelsson D Sznage M Engelsberg K Wittström E
author_sort	Samuelsson D
title	Clinical, optical coherence tomography, and fundus autofluorescence findings in patients with intraocular tumors
title_short	Clinical, optical coherence tomography, and fundus autofluorescence findings in patients with intraocular tumors
title_full	Clinical, optical coherence tomography, and fundus autofluorescence findings in patients with intraocular tumors
title_fullStr	Clinical, optical coherence tomography, and fundus autofluorescence findings in patients with intraocular tumors
title_full_unstemmed	Clinical, optical coherence tomography, and fundus autofluorescence findings in patients with intraocular tumors
title_sort	clinical, optical coherence tomography, and fundus autofluorescence findings in patients with intraocular tumors
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/6382f40351994382a4f0810864c17dec
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Clinical, optical coherence tomography, and fundus autofluorescence findings in patients with intraocular tumors

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