The first reported case of Blaptica dubia cockroach allergy

Abstract Background Periplaneta americana and Blattella germanica cockroaches are widespread, and risk of sensitization increases in urban environments where these roaches thrive as household pests. There are no prior reports of Blaptica dubia cockroach allergy, though human exposure to B. dubia is...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hannah Wangberg, Jun Mendoza, Robert Gomez, Christopher Coop, Andrew White, Katharine Woessner
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Allergy Asthma Allergic rhinitis Cockroach Blaptica dubia Dubia cockroach Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/63843fe3ba754715a24100d9ec85436f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:63843fe3ba754715a24100d9ec85436f
record_format	dspace
spelling	oai:doaj.org-article:63843fe3ba754715a24100d9ec85436f2021-11-08T11:13:15ZThe first reported case of Blaptica dubia cockroach allergy10.1186/s13223-021-00618-21710-1492https://doaj.org/article/63843fe3ba754715a24100d9ec85436f2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13223-021-00618-2https://doaj.org/toc/1710-1492Abstract Background Periplaneta americana and Blattella germanica cockroaches are widespread, and risk of sensitization increases in urban environments where these roaches thrive as household pests. There are no prior reports of Blaptica dubia cockroach allergy, though human exposure to B. dubia is increasing through commercial breeding as feeder insects. Case presentation A 50-year-old B. dubia cockroach breeder presented with progressively worsening upper and lower respiratory symptoms in recent years. Symptoms were worse with exposure to her B. dubia roach colony. Skin prick testing (SPT) to B. dubia cast skin, internal organs, and feces was performed in both the subject and a human control. Testing for P. americana and B. germanica sensitization was also performed in the subject. SDS–Polyacrylamide gel electrophoresis (PAGE), immunoblots, and enzyme-linked immunosorbent assays (ELISA) studies were performed using the subject and control serums to explore for specific IgE binding to B. dubia as well as P. americana. Our results showed SPT was positive to B. dubia internal organs in the subject and negative in the control. In the subject, SPT was negative to P. americana though intradermal (ID) testing was positive and serum specific IgE (sIgE) testing was negative to B. germanica. Immunoblotting of the subject's serum to B. dubia internal organ extract showed several distinct bands of IgE binding at 47 kilodaltons (kD), 68 kD, 74 kD, 83 kD, and 118 kD. The strongest band was at 118 kD on B. dubia immunoblotting, which was absent in P. americana on SDS-PAGE. ELISA studies showed an increased IgE response to both B. dubia and P. americana in the subject versus the control. Conclusions This case confirmed the first reported allergy to B. dubia cockroaches. There may be cross-reactivity between B. dubia and P. americana, though our case suggests SPT and sIgE testing using P. americana and B. germanica extract has potential to miss a B. dubia cockroach allergy. This allergy is likely underreported, and further study is needed to explore the natural history of B. dubia cockroach allergy.Hannah WangbergJun MendozaRobert GomezChristopher CoopAndrew WhiteKatharine WoessnerBMCarticleAllergyAsthmaAllergic rhinitisCockroachBlaptica dubiaDubia cockroachImmunologic diseases. AllergyRC581-607ENAllergy, Asthma & Clinical Immunology, Vol 17, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Allergy Asthma Allergic rhinitis Cockroach Blaptica dubia Dubia cockroach Immunologic diseases. Allergy RC581-607
spellingShingle	Allergy Asthma Allergic rhinitis Cockroach Blaptica dubia Dubia cockroach Immunologic diseases. Allergy RC581-607 Hannah Wangberg Jun Mendoza Robert Gomez Christopher Coop Andrew White Katharine Woessner The first reported case of Blaptica dubia cockroach allergy
description	Abstract Background Periplaneta americana and Blattella germanica cockroaches are widespread, and risk of sensitization increases in urban environments where these roaches thrive as household pests. There are no prior reports of Blaptica dubia cockroach allergy, though human exposure to B. dubia is increasing through commercial breeding as feeder insects. Case presentation A 50-year-old B. dubia cockroach breeder presented with progressively worsening upper and lower respiratory symptoms in recent years. Symptoms were worse with exposure to her B. dubia roach colony. Skin prick testing (SPT) to B. dubia cast skin, internal organs, and feces was performed in both the subject and a human control. Testing for P. americana and B. germanica sensitization was also performed in the subject. SDS–Polyacrylamide gel electrophoresis (PAGE), immunoblots, and enzyme-linked immunosorbent assays (ELISA) studies were performed using the subject and control serums to explore for specific IgE binding to B. dubia as well as P. americana. Our results showed SPT was positive to B. dubia internal organs in the subject and negative in the control. In the subject, SPT was negative to P. americana though intradermal (ID) testing was positive and serum specific IgE (sIgE) testing was negative to B. germanica. Immunoblotting of the subject's serum to B. dubia internal organ extract showed several distinct bands of IgE binding at 47 kilodaltons (kD), 68 kD, 74 kD, 83 kD, and 118 kD. The strongest band was at 118 kD on B. dubia immunoblotting, which was absent in P. americana on SDS-PAGE. ELISA studies showed an increased IgE response to both B. dubia and P. americana in the subject versus the control. Conclusions This case confirmed the first reported allergy to B. dubia cockroaches. There may be cross-reactivity between B. dubia and P. americana, though our case suggests SPT and sIgE testing using P. americana and B. germanica extract has potential to miss a B. dubia cockroach allergy. This allergy is likely underreported, and further study is needed to explore the natural history of B. dubia cockroach allergy.
format	article
author	Hannah Wangberg Jun Mendoza Robert Gomez Christopher Coop Andrew White Katharine Woessner
author_facet	Hannah Wangberg Jun Mendoza Robert Gomez Christopher Coop Andrew White Katharine Woessner
author_sort	Hannah Wangberg
title	The first reported case of Blaptica dubia cockroach allergy
title_short	The first reported case of Blaptica dubia cockroach allergy
title_full	The first reported case of Blaptica dubia cockroach allergy
title_fullStr	The first reported case of Blaptica dubia cockroach allergy
title_full_unstemmed	The first reported case of Blaptica dubia cockroach allergy
title_sort	first reported case of blaptica dubia cockroach allergy
publisher	BMC
publishDate	2021
url	https://doaj.org/article/63843fe3ba754715a24100d9ec85436f
work_keys_str_mv	AT hannahwangberg thefirstreportedcaseofblapticadubiacockroachallergy AT junmendoza thefirstreportedcaseofblapticadubiacockroachallergy AT robertgomez thefirstreportedcaseofblapticadubiacockroachallergy AT christophercoop thefirstreportedcaseofblapticadubiacockroachallergy AT andrewwhite thefirstreportedcaseofblapticadubiacockroachallergy AT katharinewoessner thefirstreportedcaseofblapticadubiacockroachallergy AT hannahwangberg firstreportedcaseofblapticadubiacockroachallergy AT junmendoza firstreportedcaseofblapticadubiacockroachallergy AT robertgomez firstreportedcaseofblapticadubiacockroachallergy AT christophercoop firstreportedcaseofblapticadubiacockroachallergy AT andrewwhite firstreportedcaseofblapticadubiacockroachallergy AT katharinewoessner firstreportedcaseofblapticadubiacockroachallergy
_version_	1718442337510621184

The first reported case of Blaptica dubia cockroach allergy

Ejemplares similares