Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease

Leptin regulates the sympathetic nervous system, energy expenditure and body weight through incompletely understood mechanisms. Here the authors report that Sh2b1 in leptin receptor positive neurons mediates the ability of leptin to stimulate sympathetic nerve activity in brown adipose tissue, body...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lin Jiang, Haoran Su, Xiaoyin Wu, Hong Shen, Min-Hyun Kim, Yuan Li, Martin G. Myers, Chung Owyang, Liangyou Rui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/63894fb821634352a34440714451b55e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:63894fb821634352a34440714451b55e
record_format	dspace
spelling	oai:doaj.org-article:63894fb821634352a34440714451b55e2021-12-02T14:42:11ZLeptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease10.1038/s41467-020-15328-32041-1723https://doaj.org/article/63894fb821634352a34440714451b55e2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15328-3https://doaj.org/toc/2041-1723Leptin regulates the sympathetic nervous system, energy expenditure and body weight through incompletely understood mechanisms. Here the authors report that Sh2b1 in leptin receptor positive neurons mediates the ability of leptin to stimulate sympathetic nerve activity in brown adipose tissue, body temperature and cold tolerance.Lin JiangHaoran SuXiaoyin WuHong ShenMin-Hyun KimYuan LiMartin G. MyersChung OwyangLiangyou RuiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lin Jiang Haoran Su Xiaoyin Wu Hong Shen Min-Hyun Kim Yuan Li Martin G. Myers Chung Owyang Liangyou Rui Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease
description	Leptin regulates the sympathetic nervous system, energy expenditure and body weight through incompletely understood mechanisms. Here the authors report that Sh2b1 in leptin receptor positive neurons mediates the ability of leptin to stimulate sympathetic nerve activity in brown adipose tissue, body temperature and cold tolerance.
format	article
author	Lin Jiang Haoran Su Xiaoyin Wu Hong Shen Min-Hyun Kim Yuan Li Martin G. Myers Chung Owyang Liangyou Rui
author_facet	Lin Jiang Haoran Su Xiaoyin Wu Hong Shen Min-Hyun Kim Yuan Li Martin G. Myers Chung Owyang Liangyou Rui
author_sort	Lin Jiang
title	Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease
title_short	Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease
title_full	Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease
title_fullStr	Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease
title_full_unstemmed	Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease
title_sort	leptin receptor-expressing neuron sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/63894fb821634352a34440714451b55e
work_keys_str_mv	AT linjiang leptinreceptorexpressingneuronsh2b1supportssympatheticnervoussystemandprotectsagainstobesityandmetabolicdisease AT haoransu leptinreceptorexpressingneuronsh2b1supportssympatheticnervoussystemandprotectsagainstobesityandmetabolicdisease AT xiaoyinwu leptinreceptorexpressingneuronsh2b1supportssympatheticnervoussystemandprotectsagainstobesityandmetabolicdisease AT hongshen leptinreceptorexpressingneuronsh2b1supportssympatheticnervoussystemandprotectsagainstobesityandmetabolicdisease AT minhyunkim leptinreceptorexpressingneuronsh2b1supportssympatheticnervoussystemandprotectsagainstobesityandmetabolicdisease AT yuanli leptinreceptorexpressingneuronsh2b1supportssympatheticnervoussystemandprotectsagainstobesityandmetabolicdisease AT martingmyers leptinreceptorexpressingneuronsh2b1supportssympatheticnervoussystemandprotectsagainstobesityandmetabolicdisease AT chungowyang leptinreceptorexpressingneuronsh2b1supportssympatheticnervoussystemandprotectsagainstobesityandmetabolicdisease AT liangyourui leptinreceptorexpressingneuronsh2b1supportssympatheticnervoussystemandprotectsagainstobesityandmetabolicdisease
_version_	1718389753324240896

Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease

Ejemplares similares