Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease

Calvo-Rodriguez et al. show elevated calcium levels in neuronal mitochondria in a mouse model of cerebral β-amyloidosis after plaque deposition, which precede rare neuron death events in this model. The mechanism involves toxic extracellular Aβ oligomers and the mitochondrial calcium uniporter.

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Autores principales:	Maria Calvo-Rodriguez, Steven S. Hou, Austin C. Snyder, Elizabeth K. Kharitonova, Alyssa N. Russ, Sudeshna Das, Zhanyun Fan, Alona Muzikansky, Monica Garcia-Alloza, Alberto Serrano-Pozo, Eloise Hudry, Brian J. Bacskai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/638a348449c44bb59f38a1bc9201bb6b
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spelling	oai:doaj.org-article:638a348449c44bb59f38a1bc9201bb6b2021-12-02T14:42:33ZIncreased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease10.1038/s41467-020-16074-22041-1723https://doaj.org/article/638a348449c44bb59f38a1bc9201bb6b2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16074-2https://doaj.org/toc/2041-1723Calvo-Rodriguez et al. show elevated calcium levels in neuronal mitochondria in a mouse model of cerebral β-amyloidosis after plaque deposition, which precede rare neuron death events in this model. The mechanism involves toxic extracellular Aβ oligomers and the mitochondrial calcium uniporter.Maria Calvo-RodriguezSteven S. HouAustin C. SnyderElizabeth K. KharitonovaAlyssa N. RussSudeshna DasZhanyun FanAlona MuzikanskyMonica Garcia-AllozaAlberto Serrano-PozoEloise HudryBrian J. BacskaiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maria Calvo-Rodriguez Steven S. Hou Austin C. Snyder Elizabeth K. Kharitonova Alyssa N. Russ Sudeshna Das Zhanyun Fan Alona Muzikansky Monica Garcia-Alloza Alberto Serrano-Pozo Eloise Hudry Brian J. Bacskai Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease
description	Calvo-Rodriguez et al. show elevated calcium levels in neuronal mitochondria in a mouse model of cerebral β-amyloidosis after plaque deposition, which precede rare neuron death events in this model. The mechanism involves toxic extracellular Aβ oligomers and the mitochondrial calcium uniporter.
format	article
author	Maria Calvo-Rodriguez Steven S. Hou Austin C. Snyder Elizabeth K. Kharitonova Alyssa N. Russ Sudeshna Das Zhanyun Fan Alona Muzikansky Monica Garcia-Alloza Alberto Serrano-Pozo Eloise Hudry Brian J. Bacskai
author_facet	Maria Calvo-Rodriguez Steven S. Hou Austin C. Snyder Elizabeth K. Kharitonova Alyssa N. Russ Sudeshna Das Zhanyun Fan Alona Muzikansky Monica Garcia-Alloza Alberto Serrano-Pozo Eloise Hudry Brian J. Bacskai
author_sort	Maria Calvo-Rodriguez
title	Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease
title_short	Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease
title_full	Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease
title_fullStr	Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease
title_full_unstemmed	Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease
title_sort	increased mitochondrial calcium levels associated with neuronal death in a mouse model of alzheimer’s disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/638a348449c44bb59f38a1bc9201bb6b
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Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease

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