Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel

G-protein-gated inward rectifying potassium channels (GIRKs) require Gβγ subunits and phosphorylated phosphatidylinositides (PIPs) for gating. Here authors use native ion mobility mass spectrometry to monitor small molecule binding events to GIRK2 and shed light on the selectivity of GIRK2 towards P...

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Autores principales:	Yang Liu, Catherine E. LoCaste, Wen Liu, Michael L. Poltash, David H. Russell, Arthur Laganowsky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/638c1f32d632456dae3b164c127d399b
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id	oai:doaj.org-article:638c1f32d632456dae3b164c127d399b
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spelling	oai:doaj.org-article:638c1f32d632456dae3b164c127d399b2021-12-02T15:35:47ZSelective binding of a toxin and phosphatidylinositides to a mammalian potassium channel10.1038/s41467-019-09333-42041-1723https://doaj.org/article/638c1f32d632456dae3b164c127d399b2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09333-4https://doaj.org/toc/2041-1723G-protein-gated inward rectifying potassium channels (GIRKs) require Gβγ subunits and phosphorylated phosphatidylinositides (PIPs) for gating. Here authors use native ion mobility mass spectrometry to monitor small molecule binding events to GIRK2 and shed light on the selectivity of GIRK2 towards PIPs.Yang LiuCatherine E. LoCasteWen LiuMichael L. PoltashDavid H. RussellArthur LaganowskyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yang Liu Catherine E. LoCaste Wen Liu Michael L. Poltash David H. Russell Arthur Laganowsky Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel
description	G-protein-gated inward rectifying potassium channels (GIRKs) require Gβγ subunits and phosphorylated phosphatidylinositides (PIPs) for gating. Here authors use native ion mobility mass spectrometry to monitor small molecule binding events to GIRK2 and shed light on the selectivity of GIRK2 towards PIPs.
format	article
author	Yang Liu Catherine E. LoCaste Wen Liu Michael L. Poltash David H. Russell Arthur Laganowsky
author_facet	Yang Liu Catherine E. LoCaste Wen Liu Michael L. Poltash David H. Russell Arthur Laganowsky
author_sort	Yang Liu
title	Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel
title_short	Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel
title_full	Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel
title_fullStr	Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel
title_full_unstemmed	Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel
title_sort	selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/638c1f32d632456dae3b164c127d399b
work_keys_str_mv	AT yangliu selectivebindingofatoxinandphosphatidylinositidestoamammalianpotassiumchannel AT catherineelocaste selectivebindingofatoxinandphosphatidylinositidestoamammalianpotassiumchannel AT wenliu selectivebindingofatoxinandphosphatidylinositidestoamammalianpotassiumchannel AT michaellpoltash selectivebindingofatoxinandphosphatidylinositidestoamammalianpotassiumchannel AT davidhrussell selectivebindingofatoxinandphosphatidylinositidestoamammalianpotassiumchannel AT arthurlaganowsky selectivebindingofatoxinandphosphatidylinositidestoamammalianpotassiumchannel
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Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel

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