Schizophyllum commune induced genotoxic and cytotoxic effects in Spodoptera litura

Abstract In search for ecofriendly alternatives to chemical insecticides the present study was conducted to assess the insecticidal potential of an endophytic fungus Schizophyllum commune and its mechanism of toxicity by studying genotoxic and cytotoxic effects as well as repair potential using Spod...

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Autores principales:	Mandeep Kaur, Pooja Chadha, Sanehdeep Kaur, Amarjeet Kaur, Rajvir Kaur, Arun Kumar Yadav, Ramandeep Kaur
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/638f729ce6f84faf98dbdda397158bfd
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spelling	oai:doaj.org-article:638f729ce6f84faf98dbdda397158bfd2021-12-02T15:07:49ZSchizophyllum commune induced genotoxic and cytotoxic effects in Spodoptera litura10.1038/s41598-018-22919-02045-2322https://doaj.org/article/638f729ce6f84faf98dbdda397158bfd2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-22919-0https://doaj.org/toc/2045-2322Abstract In search for ecofriendly alternatives to chemical insecticides the present study was conducted to assess the insecticidal potential of an endophytic fungus Schizophyllum commune and its mechanism of toxicity by studying genotoxic and cytotoxic effects as well as repair potential using Spodoptera litura (Fabricius) as a model. Different endophytic fungi were isolated and tested for their insecticidal potential against S. litura. Among the tested endophytic fungi maximum mortality against S. litura was exhibited by S. commune isolated from Aloe vera. Extended development, reduced adult emergence was observed in larvae fed on diet supplemented with fungal extract. In addition to it the fungus also has propensity to increase oxidative stress which leads to significantly higher DNA damage. The significantly lower frequency of living haemocytes and increased frequency of apoptotic and necrotic cells was also observed in larvae treated with fungal extract. The extent of recovery of damage caused by fungus was found to be very low indicating long term effect of treatment. Phytochemical analysis revealed the presence of various phenolics, terpenoids and protein in fungal extract. Biosafety analysis indicated the non toxic nature of extract. This is the first report showing the insecticidal potential of S. commune and the genotoxic and cytotoxic effects associated with it.Mandeep KaurPooja ChadhaSanehdeep KaurAmarjeet KaurRajvir KaurArun Kumar YadavRamandeep KaurNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mandeep Kaur Pooja Chadha Sanehdeep Kaur Amarjeet Kaur Rajvir Kaur Arun Kumar Yadav Ramandeep Kaur Schizophyllum commune induced genotoxic and cytotoxic effects in Spodoptera litura
description	Abstract In search for ecofriendly alternatives to chemical insecticides the present study was conducted to assess the insecticidal potential of an endophytic fungus Schizophyllum commune and its mechanism of toxicity by studying genotoxic and cytotoxic effects as well as repair potential using Spodoptera litura (Fabricius) as a model. Different endophytic fungi were isolated and tested for their insecticidal potential against S. litura. Among the tested endophytic fungi maximum mortality against S. litura was exhibited by S. commune isolated from Aloe vera. Extended development, reduced adult emergence was observed in larvae fed on diet supplemented with fungal extract. In addition to it the fungus also has propensity to increase oxidative stress which leads to significantly higher DNA damage. The significantly lower frequency of living haemocytes and increased frequency of apoptotic and necrotic cells was also observed in larvae treated with fungal extract. The extent of recovery of damage caused by fungus was found to be very low indicating long term effect of treatment. Phytochemical analysis revealed the presence of various phenolics, terpenoids and protein in fungal extract. Biosafety analysis indicated the non toxic nature of extract. This is the first report showing the insecticidal potential of S. commune and the genotoxic and cytotoxic effects associated with it.
format	article
author	Mandeep Kaur Pooja Chadha Sanehdeep Kaur Amarjeet Kaur Rajvir Kaur Arun Kumar Yadav Ramandeep Kaur
author_facet	Mandeep Kaur Pooja Chadha Sanehdeep Kaur Amarjeet Kaur Rajvir Kaur Arun Kumar Yadav Ramandeep Kaur
author_sort	Mandeep Kaur
title	Schizophyllum commune induced genotoxic and cytotoxic effects in Spodoptera litura
title_short	Schizophyllum commune induced genotoxic and cytotoxic effects in Spodoptera litura
title_full	Schizophyllum commune induced genotoxic and cytotoxic effects in Spodoptera litura
title_fullStr	Schizophyllum commune induced genotoxic and cytotoxic effects in Spodoptera litura
title_full_unstemmed	Schizophyllum commune induced genotoxic and cytotoxic effects in Spodoptera litura
title_sort	schizophyllum commune induced genotoxic and cytotoxic effects in spodoptera litura
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/638f729ce6f84faf98dbdda397158bfd
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Schizophyllum commune induced genotoxic and cytotoxic effects in Spodoptera litura

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