Pharmacophore modeling and virtual screening for the discovery of new type 4 cAMP phosphodiesterase (PDE4) inhibitors.
Type 4 cAMP phosphodiesterase (PDE4) inhibitors show a broad spectrum of anti-inflammatory effects in almost all kinds of inflamed cells, by an increase in cAMP levels which is a pivotal second messenger responsible for various biological processes. These inhibitors are now considered as the potenti...
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Autores principales: | Miaomiao Niu, Fenggong Dong, Shi Tang, Guissi Fida, Jingyi Qin, Jiadan Qiu, Kangbo Liu, Weidong Gao, Yueqing Gu |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2013
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Materias: | |
Acceso en línea: | https://doaj.org/article/63918da4b50743f093a8ff935517bd30 |
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