Pharmacophore modeling and virtual screening for the discovery of new type 4 cAMP phosphodiesterase (PDE4) inhibitors.

Type 4 cAMP phosphodiesterase (PDE4) inhibitors show a broad spectrum of anti-inflammatory effects in almost all kinds of inflamed cells, by an increase in cAMP levels which is a pivotal second messenger responsible for various biological processes. These inhibitors are now considered as the potenti...

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Autores principales: Miaomiao Niu, Fenggong Dong, Shi Tang, Guissi Fida, Jingyi Qin, Jiadan Qiu, Kangbo Liu, Weidong Gao, Yueqing Gu
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/63918da4b50743f093a8ff935517bd30
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