Mortality and Loss to Follow-Up Among HIV-Exposed Infants After Option B+ Guideline Implementation in Amhara Regional State Referral Hospitals, Ethiopia

Background: Prevention of mother-to-child transmission of HIV program (PMTCT) is a comprehensive approach that aimed for the wellbeing of all HIV-infected women, to prevent new HIV infection among infants born to HIV-positive mothers, and providing management for HIV-positive women and infants. Neve...

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Autores principales:	Mesfin Wudu Kassaw, Ayele Mamo Abebe, Biruk Beletew Abate, Mikiyas Amare Getu, Ayelign Mengesha Kassie
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	exposed infants referral hospitals Amhara region loss to follow-up mortality Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/6392dc1b71a3414da18b0ffeb932dd03
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spelling	oai:doaj.org-article:6392dc1b71a3414da18b0ffeb932dd032021-11-10T08:29:14ZMortality and Loss to Follow-Up Among HIV-Exposed Infants After Option B+ Guideline Implementation in Amhara Regional State Referral Hospitals, Ethiopia2296-236010.3389/fped.2021.591963https://doaj.org/article/6392dc1b71a3414da18b0ffeb932dd032021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fped.2021.591963/fullhttps://doaj.org/toc/2296-2360Background: Prevention of mother-to-child transmission of HIV program (PMTCT) is a comprehensive approach that aimed for the wellbeing of all HIV-infected women, to prevent new HIV infection among infants born to HIV-positive mothers, and providing management for HIV-positive women and infants. Nevertheless, there was considerably high attrition within the prevention of mother-to-child transmission programs that was merely because of loss to follow-up (LTFU) followed by mortality. In resource-limited countries, one-third of infected children die before 1 year, and more than half of them die before 2 years. The aim of this study was to assess the prevalence or incidence of mortality and LTFU among infants born from HIV-positive mothers in the Amhara regional state referral hospitals, Ethiopia.Methods: This study was conducted in five Amhara regional state referral hospitals' prevention of mother-to-child transmission departments. A simple random sampling technique with proportional allocation was used to assess the outcomes of 221 exposed infants. A retrospective cohort design was used in selecting the 221 exposed infants' document from the referral hospitals of the region, Amhara. The exposed infants' profiles were documented between January 1, 2014 and May 30, 2017.Results: This study described attritions (death and loss-to-follow-up) of exposed babies in PMTCT departments of Amhara regional state referral hospitals in Ethiopia. In this study, low LTFU with zero death was reported. Residence, immunization status of babies, and place of delivery were independent factors of LTFU.Conclusions: The cumulative incidence of mortality in this study was zero. This assured that the recommended option is substantial for the elimination of HIV-caused death in 2030 as per WHO plan. However, the cumulative incidence of LTFU was not zero.Mesfin Wudu KassawAyele Mamo AbebeBiruk Beletew AbateMikiyas Amare GetuAyelign Mengesha KassieFrontiers Media S.A.articleexposed infantsreferral hospitalsAmhara regionloss to follow-upmortalityPediatricsRJ1-570ENFrontiers in Pediatrics, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	exposed infants referral hospitals Amhara region loss to follow-up mortality Pediatrics RJ1-570
spellingShingle	exposed infants referral hospitals Amhara region loss to follow-up mortality Pediatrics RJ1-570 Mesfin Wudu Kassaw Ayele Mamo Abebe Biruk Beletew Abate Mikiyas Amare Getu Ayelign Mengesha Kassie Mortality and Loss to Follow-Up Among HIV-Exposed Infants After Option B+ Guideline Implementation in Amhara Regional State Referral Hospitals, Ethiopia
description	Background: Prevention of mother-to-child transmission of HIV program (PMTCT) is a comprehensive approach that aimed for the wellbeing of all HIV-infected women, to prevent new HIV infection among infants born to HIV-positive mothers, and providing management for HIV-positive women and infants. Nevertheless, there was considerably high attrition within the prevention of mother-to-child transmission programs that was merely because of loss to follow-up (LTFU) followed by mortality. In resource-limited countries, one-third of infected children die before 1 year, and more than half of them die before 2 years. The aim of this study was to assess the prevalence or incidence of mortality and LTFU among infants born from HIV-positive mothers in the Amhara regional state referral hospitals, Ethiopia.Methods: This study was conducted in five Amhara regional state referral hospitals' prevention of mother-to-child transmission departments. A simple random sampling technique with proportional allocation was used to assess the outcomes of 221 exposed infants. A retrospective cohort design was used in selecting the 221 exposed infants' document from the referral hospitals of the region, Amhara. The exposed infants' profiles were documented between January 1, 2014 and May 30, 2017.Results: This study described attritions (death and loss-to-follow-up) of exposed babies in PMTCT departments of Amhara regional state referral hospitals in Ethiopia. In this study, low LTFU with zero death was reported. Residence, immunization status of babies, and place of delivery were independent factors of LTFU.Conclusions: The cumulative incidence of mortality in this study was zero. This assured that the recommended option is substantial for the elimination of HIV-caused death in 2030 as per WHO plan. However, the cumulative incidence of LTFU was not zero.
format	article
author	Mesfin Wudu Kassaw Ayele Mamo Abebe Biruk Beletew Abate Mikiyas Amare Getu Ayelign Mengesha Kassie
author_facet	Mesfin Wudu Kassaw Ayele Mamo Abebe Biruk Beletew Abate Mikiyas Amare Getu Ayelign Mengesha Kassie
author_sort	Mesfin Wudu Kassaw
title	Mortality and Loss to Follow-Up Among HIV-Exposed Infants After Option B+ Guideline Implementation in Amhara Regional State Referral Hospitals, Ethiopia
title_short	Mortality and Loss to Follow-Up Among HIV-Exposed Infants After Option B+ Guideline Implementation in Amhara Regional State Referral Hospitals, Ethiopia
title_full	Mortality and Loss to Follow-Up Among HIV-Exposed Infants After Option B+ Guideline Implementation in Amhara Regional State Referral Hospitals, Ethiopia
title_fullStr	Mortality and Loss to Follow-Up Among HIV-Exposed Infants After Option B+ Guideline Implementation in Amhara Regional State Referral Hospitals, Ethiopia
title_full_unstemmed	Mortality and Loss to Follow-Up Among HIV-Exposed Infants After Option B+ Guideline Implementation in Amhara Regional State Referral Hospitals, Ethiopia
title_sort	mortality and loss to follow-up among hiv-exposed infants after option b+ guideline implementation in amhara regional state referral hospitals, ethiopia
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6392dc1b71a3414da18b0ffeb932dd03
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Mortality and Loss to Follow-Up Among HIV-Exposed Infants After Option B+ Guideline Implementation in Amhara Regional State Referral Hospitals, Ethiopia

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