Potent in vitro and in vivo antifungal activity of a small molecule host defense peptide mimic through a membrane-active mechanism

Potent in vitro and in vivo antifungal activity of a small molecule host defense peptide mimic through a membrane-active mechanism

Abstract Lethal systemic fungal infections of Candida species are increasingly common, especially in immune compromised patients. By in vitro screening of small molecule mimics of naturally occurring host defense peptides (HDP), we have identified several active antifungal molecules, which also exhi...

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Autores principales: Lorenzo P. Menzel, Hossain Mobaswar Chowdhury, Jorge Adrian Masso-Silva, William Ruddick, Klaudia Falkovsky, Rafael Vorona, Andrew Malsbary, Kartikeya Cherabuddi, Lisa K. Ryan, Kristina M. DiFranco, David C. Brice, Michael J. Costanzo, Damian Weaver, Katie B. Freeman, Richard W. Scott, Gill Diamond
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/639646d14ae24c37b3def738170a856b
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