A chemical toolbox for the study of bromodomains and epigenetic signaling

A chemical toolbox for the study of bromodomains and epigenetic signaling

Bromodomains are conserved protein interaction modules that recognize acetyl-lysine modifications. Here the authors present a set of 25 selective small molecule inhibitors covering 29 human bromodomain targets and comprehensively evaluate the selectivity of this probe-set.

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Autores principales: Qin Wu, David Heidenreich, Stanley Zhou, Suzanne Ackloo, Andreas Krämer, Kiran Nakka, Evelyne Lima-Fernandes, Genevieve Deblois, Shili Duan, Ravi N. Vellanki, Fengling Li, Masoud Vedadi, Jeffrey Dilworth, Mathieu Lupien, Paul E. Brennan, Cheryl H. Arrowsmith, Susanne Müller, Oleg Fedorov, Panagis Filippakopoulos, Stefan Knapp
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/6396da47b45340898d36418988b2a14e
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spelling oai:doaj.org-article:6396da47b45340898d36418988b2a14e2021-12-02T14:40:17ZA chemical toolbox for the study of bromodomains and epigenetic signaling10.1038/s41467-019-09672-22041-1723https://doaj.org/article/6396da47b45340898d36418988b2a14e2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09672-2https://doaj.org/toc/2041-1723Bromodomains are conserved protein interaction modules that recognize acetyl-lysine modifications. Here the authors present a set of 25 selective small molecule inhibitors covering 29 human bromodomain targets and comprehensively evaluate the selectivity of this probe-set.Qin WuDavid HeidenreichStanley ZhouSuzanne AcklooAndreas KrämerKiran NakkaEvelyne Lima-FernandesGenevieve DebloisShili DuanRavi N. VellankiFengling LiMasoud VedadiJeffrey DilworthMathieu LupienPaul E. BrennanCheryl H. ArrowsmithSusanne MüllerOleg FedorovPanagis FilippakopoulosStefan KnappNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Qin Wu
David Heidenreich
Stanley Zhou
Suzanne Ackloo
Andreas Krämer
Kiran Nakka
Evelyne Lima-Fernandes
Genevieve Deblois
Shili Duan
Ravi N. Vellanki
Fengling Li
Masoud Vedadi
Jeffrey Dilworth
Mathieu Lupien
Paul E. Brennan
Cheryl H. Arrowsmith
Susanne Müller
Oleg Fedorov
Panagis Filippakopoulos
Stefan Knapp
A chemical toolbox for the study of bromodomains and epigenetic signaling
description Bromodomains are conserved protein interaction modules that recognize acetyl-lysine modifications. Here the authors present a set of 25 selective small molecule inhibitors covering 29 human bromodomain targets and comprehensively evaluate the selectivity of this probe-set.
format article
author Qin Wu
David Heidenreich
Stanley Zhou
Suzanne Ackloo
Andreas Krämer
Kiran Nakka
Evelyne Lima-Fernandes
Genevieve Deblois
Shili Duan
Ravi N. Vellanki
Fengling Li
Masoud Vedadi
Jeffrey Dilworth
Mathieu Lupien
Paul E. Brennan
Cheryl H. Arrowsmith
Susanne Müller
Oleg Fedorov
Panagis Filippakopoulos
Stefan Knapp
author_facet Qin Wu
David Heidenreich
Stanley Zhou
Suzanne Ackloo
Andreas Krämer
Kiran Nakka
Evelyne Lima-Fernandes
Genevieve Deblois
Shili Duan
Ravi N. Vellanki
Fengling Li
Masoud Vedadi
Jeffrey Dilworth
Mathieu Lupien
Paul E. Brennan
Cheryl H. Arrowsmith
Susanne Müller
Oleg Fedorov
Panagis Filippakopoulos
Stefan Knapp
author_sort Qin Wu
title A chemical toolbox for the study of bromodomains and epigenetic signaling
title_short A chemical toolbox for the study of bromodomains and epigenetic signaling
title_full A chemical toolbox for the study of bromodomains and epigenetic signaling
title_fullStr A chemical toolbox for the study of bromodomains and epigenetic signaling
title_full_unstemmed A chemical toolbox for the study of bromodomains and epigenetic signaling
title_sort chemical toolbox for the study of bromodomains and epigenetic signaling
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/6396da47b45340898d36418988b2a14e
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