Topological scoring of protein interaction networks

Inferring direct protein−protein interactions (PPIs) and modules in PPI networks remains a challenge. Here, the authors introduce an algorithm to infer potential direct PPIs from quantitative proteomic AP-MS data by identifying enriched interactions of each bait relative to the other baits.

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Autores principales:	Mihaela E. Sardiu, Joshua M. Gilmore, Brad D. Groppe, Arnob Dutta, Laurence Florens, Michael P. Washburn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/639b28dd37f34009bb594be0793601cb
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id	oai:doaj.org-article:639b28dd37f34009bb594be0793601cb
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spelling	oai:doaj.org-article:639b28dd37f34009bb594be0793601cb2021-12-02T15:35:48ZTopological scoring of protein interaction networks10.1038/s41467-019-09123-y2041-1723https://doaj.org/article/639b28dd37f34009bb594be0793601cb2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09123-yhttps://doaj.org/toc/2041-1723Inferring direct protein−protein interactions (PPIs) and modules in PPI networks remains a challenge. Here, the authors introduce an algorithm to infer potential direct PPIs from quantitative proteomic AP-MS data by identifying enriched interactions of each bait relative to the other baits.Mihaela E. SardiuJoshua M. GilmoreBrad D. GroppeArnob DuttaLaurence FlorensMichael P. WashburnNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mihaela E. Sardiu Joshua M. Gilmore Brad D. Groppe Arnob Dutta Laurence Florens Michael P. Washburn Topological scoring of protein interaction networks
description	Inferring direct protein−protein interactions (PPIs) and modules in PPI networks remains a challenge. Here, the authors introduce an algorithm to infer potential direct PPIs from quantitative proteomic AP-MS data by identifying enriched interactions of each bait relative to the other baits.
format	article
author	Mihaela E. Sardiu Joshua M. Gilmore Brad D. Groppe Arnob Dutta Laurence Florens Michael P. Washburn
author_facet	Mihaela E. Sardiu Joshua M. Gilmore Brad D. Groppe Arnob Dutta Laurence Florens Michael P. Washburn
author_sort	Mihaela E. Sardiu
title	Topological scoring of protein interaction networks
title_short	Topological scoring of protein interaction networks
title_full	Topological scoring of protein interaction networks
title_fullStr	Topological scoring of protein interaction networks
title_full_unstemmed	Topological scoring of protein interaction networks
title_sort	topological scoring of protein interaction networks
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/639b28dd37f34009bb594be0793601cb
work_keys_str_mv	AT mihaelaesardiu topologicalscoringofproteininteractionnetworks AT joshuamgilmore topologicalscoringofproteininteractionnetworks AT braddgroppe topologicalscoringofproteininteractionnetworks AT arnobdutta topologicalscoringofproteininteractionnetworks AT laurenceflorens topologicalscoringofproteininteractionnetworks AT michaelpwashburn topologicalscoringofproteininteractionnetworks
_version_	1718386414308032512

Topological scoring of protein interaction networks

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