A Systems Toxicology-based Approach Reveals Biological Pathways Dysregulated by Prenatal Arsenic Exposure
Background: <a title="Learn more about Prenatal Exposure" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/prenatal-exposure">Prenatal exposure</a> to inorganic arsenic (iAs) is associated with dysregulated fetal gene and protein expression. Potential...
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Ubiquity Press
2016
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/639d6b76b90e4e08996aa9ea273a22d8 |
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| Sumario: | Background: <a title="Learn more about Prenatal Exposure" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/prenatal-exposure">Prenatal exposure</a> to inorganic arsenic (iAs) is associated with dysregulated fetal gene and protein expression. Potential biological mechanisms that underlie these changes include, but are not limited to, changes to the epigenome. Objective: The aim of the present study was to identify whether the expression of key genes, proteins, or both and their associated biological pathways are perturbed by compiling datasets from studies on prenatal arsenic exposure. Methods: We compiled datasets from 12 studies that analyzed the relationship between prenatal iAs exposure and changes to the fetal epigenome (5-methyl cytosine), <a title="Learn more about Transcriptome" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/transcriptome">transcriptome</a> (mRNA expression), and/or <a title="Learn more about Proteome" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/proteome">proteome</a> (protein expression). Findings: Across the 12 studies, a set of 845 unique genes was identified and found to enrich for their role in biological pathways, including the <a title="Learn more about Peroxisome Proliferator-activated Receptor" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/peroxisome-proliferator-activated-receptor">peroxisome proliferator-activated receptor</a>, nuclear factor of kappa light polypeptide gene enhancer in <a title="Learn more about B Cell" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/b-cell">B-cells</a> inhibitor, and the <a title="Learn more about Glucocorticoid Receptor" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/glucocorticoid-receptor">glucocorticoid receptor</a>. <a title="Learn more about Tumor Necrosis Factor" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/tumor-necrosis-factor">Tumor necrosis factor</a> was identified as a putative cellular regulator underlying most (n = 277) of the identified iAs-associated gene or protein expression changes. Conclusions: The identification of the common set of genes across numerous human cohorts suggests a conserved biological response to prenatal arsenic exposure. The genes/proteins and their associated pathways may be useful in future mechanistic investigations of iAs associated diseases. |
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