A Systems Toxicology-based Approach Reveals Biological Pathways Dysregulated by Prenatal Arsenic Exposure

Background: <a title="Learn more about Prenatal Exposure" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/prenatal-exposure">Prenatal exposure</a> to inorganic arsenic (iAs) is associated with dysregulated fetal gene and protein expression. Potential...

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Autores principales:	Jessica E. Laine, Rebecca C. Fry
Formato:	article
Lenguaje:	EN
Publicado:	Ubiquity Press 2016
Materias:	CpG methylation gene expression inorganic arsenic microRNA expression protein expression Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/639d6b76b90e4e08996aa9ea273a22d8
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spelling	oai:doaj.org-article:639d6b76b90e4e08996aa9ea273a22d82021-12-02T04:24:26ZA Systems Toxicology-based Approach Reveals Biological Pathways Dysregulated by Prenatal Arsenic Exposure2214-999610.1016/j.aogh.2016.01.015https://doaj.org/article/639d6b76b90e4e08996aa9ea273a22d82016-06-01T00:00:00Zhttps://annalsofglobalhealth.org/articles/1176https://doaj.org/toc/2214-9996Background: <a title="Learn more about Prenatal Exposure" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/prenatal-exposure">Prenatal exposure</a> to inorganic arsenic (iAs) is associated with dysregulated fetal gene and protein expression. Potential biological mechanisms that underlie these changes include, but are not limited to, changes to the epigenome. Objective: The aim of the present study was to identify whether the expression of key genes, proteins, or both and their associated biological pathways are perturbed by compiling datasets from studies on prenatal arsenic exposure. Methods: We compiled datasets from 12 studies that analyzed the relationship between prenatal iAs exposure and changes to the fetal epigenome (5-methyl cytosine), <a title="Learn more about Transcriptome" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/transcriptome">transcriptome</a> (mRNA expression), and/or <a title="Learn more about Proteome" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/proteome">proteome</a> (protein expression). Findings: Across the 12 studies, a set of 845 unique genes was identified and found to enrich for their role in biological pathways, including the <a title="Learn more about Peroxisome Proliferator-activated Receptor" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/peroxisome-proliferator-activated-receptor">peroxisome proliferator-activated receptor</a>, nuclear factor of kappa light polypeptide gene enhancer in <a title="Learn more about B Cell" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/b-cell">B-cells</a> inhibitor, and the <a title="Learn more about Glucocorticoid Receptor" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/glucocorticoid-receptor">glucocorticoid receptor</a>. <a title="Learn more about Tumor Necrosis Factor" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/tumor-necrosis-factor">Tumor necrosis factor</a> was identified as a putative cellular regulator underlying most (n = 277) of the identified iAs-associated gene or protein expression changes. Conclusions: The identification of the common set of genes across numerous human cohorts suggests a conserved biological response to prenatal arsenic exposure. The genes/proteins and their associated pathways may be useful in future mechanistic investigations of iAs associated diseases.Jessica E. LaineRebecca C. FryUbiquity PressarticleCpG methylationgene expressioninorganic arsenicmicroRNA expressionprotein expressionInfectious and parasitic diseasesRC109-216Public aspects of medicineRA1-1270ENAnnals of Global Health, Vol 82, Iss 1, Pp 189-196 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	CpG methylation gene expression inorganic arsenic microRNA expression protein expression Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
spellingShingle	CpG methylation gene expression inorganic arsenic microRNA expression protein expression Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270 Jessica E. Laine Rebecca C. Fry A Systems Toxicology-based Approach Reveals Biological Pathways Dysregulated by Prenatal Arsenic Exposure
description	Background: <a title="Learn more about Prenatal Exposure" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/prenatal-exposure">Prenatal exposure</a> to inorganic arsenic (iAs) is associated with dysregulated fetal gene and protein expression. Potential biological mechanisms that underlie these changes include, but are not limited to, changes to the epigenome. Objective: The aim of the present study was to identify whether the expression of key genes, proteins, or both and their associated biological pathways are perturbed by compiling datasets from studies on prenatal arsenic exposure. Methods: We compiled datasets from 12 studies that analyzed the relationship between prenatal iAs exposure and changes to the fetal epigenome (5-methyl cytosine), <a title="Learn more about Transcriptome" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/transcriptome">transcriptome</a> (mRNA expression), and/or <a title="Learn more about Proteome" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/proteome">proteome</a> (protein expression). Findings: Across the 12 studies, a set of 845 unique genes was identified and found to enrich for their role in biological pathways, including the <a title="Learn more about Peroxisome Proliferator-activated Receptor" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/peroxisome-proliferator-activated-receptor">peroxisome proliferator-activated receptor</a>, nuclear factor of kappa light polypeptide gene enhancer in <a title="Learn more about B Cell" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/b-cell">B-cells</a> inhibitor, and the <a title="Learn more about Glucocorticoid Receptor" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/glucocorticoid-receptor">glucocorticoid receptor</a>. <a title="Learn more about Tumor Necrosis Factor" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/tumor-necrosis-factor">Tumor necrosis factor</a> was identified as a putative cellular regulator underlying most (n = 277) of the identified iAs-associated gene or protein expression changes. Conclusions: The identification of the common set of genes across numerous human cohorts suggests a conserved biological response to prenatal arsenic exposure. The genes/proteins and their associated pathways may be useful in future mechanistic investigations of iAs associated diseases.
format	article
author	Jessica E. Laine Rebecca C. Fry
author_facet	Jessica E. Laine Rebecca C. Fry
author_sort	Jessica E. Laine
title	A Systems Toxicology-based Approach Reveals Biological Pathways Dysregulated by Prenatal Arsenic Exposure
title_short	A Systems Toxicology-based Approach Reveals Biological Pathways Dysregulated by Prenatal Arsenic Exposure
title_full	A Systems Toxicology-based Approach Reveals Biological Pathways Dysregulated by Prenatal Arsenic Exposure
title_fullStr	A Systems Toxicology-based Approach Reveals Biological Pathways Dysregulated by Prenatal Arsenic Exposure
title_full_unstemmed	A Systems Toxicology-based Approach Reveals Biological Pathways Dysregulated by Prenatal Arsenic Exposure
title_sort	systems toxicology-based approach reveals biological pathways dysregulated by prenatal arsenic exposure
publisher	Ubiquity Press
publishDate	2016
url	https://doaj.org/article/639d6b76b90e4e08996aa9ea273a22d8
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A Systems Toxicology-based Approach Reveals Biological Pathways Dysregulated by Prenatal Arsenic Exposure

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