Elevated plasma pentraxin-3 in polycystic ovary syndrome is associated with hyperandrogenism: a case-control study

Abstract Background Pentraxin 3 (PTX3) - a crucial humoral innate immunity component – is related to obesity and cardiovascular complications in women who suffer from polycystic ovary syndrome (PCOS). However, the circulating PTX3 level in PCOS is still debated. In this study, we aimed to evaluate P...

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Autores principales:	Congcong Jin, Kexin Zou, Yue Xu, Haiyan Yang, Jiexue Pan
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Polycystic ovary syndrome PTX3 Hyperandrogenism Innate immunology Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/639fd9adb8ac4ee1908bac5e1b1f379d
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spelling	oai:doaj.org-article:639fd9adb8ac4ee1908bac5e1b1f379d2021-12-05T12:03:15ZElevated plasma pentraxin-3 in polycystic ovary syndrome is associated with hyperandrogenism: a case-control study10.1186/s12902-021-00886-41472-6823https://doaj.org/article/639fd9adb8ac4ee1908bac5e1b1f379d2021-12-01T00:00:00Zhttps://doi.org/10.1186/s12902-021-00886-4https://doaj.org/toc/1472-6823Abstract Background Pentraxin 3 (PTX3) - a crucial humoral innate immunity component – is related to obesity and cardiovascular complications in women who suffer from polycystic ovary syndrome (PCOS). However, the circulating PTX3 level in PCOS is still debated. In this study, we aimed to evaluate PTX3 plasma levels in PCOS women of childbearing age, and find possible endocrine/metabolic factors that could affect this level. Methods A total of 360 women were enrolled: 120 PCOS women and 240 body mass index (BMI) matched normally ovulating women. Blood samples were collected on the third day of natural menstrual cycle or from the bleeding after progesterone withdrawal. The PTX3 concentration was measured by immunoassay. Results The PTX3 plasma level was significantly higher in PCOS women compared to controls. There was a positive correlation between PTX3 plasma level and PCOS diagnosis, overweight, cycle length, serum LH to FSH ratio, estradiol, total testosterone (TT) on the third day of menstrual cycle, antral follicle count (AFC), as well as uric acid. Multivariant linear regression analysis indicated that participants’ serum PTX3 levels were proportional to the circulating TT level, existence of PCOS, basal estradiol level and AFC. Conclusions Overall, the circulating PTX3 level was elevated in PCOS women and significantly associated with the presence of hyperandrogenism. This study provided the basis for further in-depth researches regarding PTX3 role in PCOS pathophysiology.Congcong JinKexin ZouYue XuHaiyan YangJiexue PanBMCarticlePolycystic ovary syndromePTX3HyperandrogenismInnate immunologyDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENBMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Polycystic ovary syndrome PTX3 Hyperandrogenism Innate immunology Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	Polycystic ovary syndrome PTX3 Hyperandrogenism Innate immunology Diseases of the endocrine glands. Clinical endocrinology RC648-665 Congcong Jin Kexin Zou Yue Xu Haiyan Yang Jiexue Pan Elevated plasma pentraxin-3 in polycystic ovary syndrome is associated with hyperandrogenism: a case-control study
description	Abstract Background Pentraxin 3 (PTX3) - a crucial humoral innate immunity component – is related to obesity and cardiovascular complications in women who suffer from polycystic ovary syndrome (PCOS). However, the circulating PTX3 level in PCOS is still debated. In this study, we aimed to evaluate PTX3 plasma levels in PCOS women of childbearing age, and find possible endocrine/metabolic factors that could affect this level. Methods A total of 360 women were enrolled: 120 PCOS women and 240 body mass index (BMI) matched normally ovulating women. Blood samples were collected on the third day of natural menstrual cycle or from the bleeding after progesterone withdrawal. The PTX3 concentration was measured by immunoassay. Results The PTX3 plasma level was significantly higher in PCOS women compared to controls. There was a positive correlation between PTX3 plasma level and PCOS diagnosis, overweight, cycle length, serum LH to FSH ratio, estradiol, total testosterone (TT) on the third day of menstrual cycle, antral follicle count (AFC), as well as uric acid. Multivariant linear regression analysis indicated that participants’ serum PTX3 levels were proportional to the circulating TT level, existence of PCOS, basal estradiol level and AFC. Conclusions Overall, the circulating PTX3 level was elevated in PCOS women and significantly associated with the presence of hyperandrogenism. This study provided the basis for further in-depth researches regarding PTX3 role in PCOS pathophysiology.
format	article
author	Congcong Jin Kexin Zou Yue Xu Haiyan Yang Jiexue Pan
author_facet	Congcong Jin Kexin Zou Yue Xu Haiyan Yang Jiexue Pan
author_sort	Congcong Jin
title	Elevated plasma pentraxin-3 in polycystic ovary syndrome is associated with hyperandrogenism: a case-control study
title_short	Elevated plasma pentraxin-3 in polycystic ovary syndrome is associated with hyperandrogenism: a case-control study
title_full	Elevated plasma pentraxin-3 in polycystic ovary syndrome is associated with hyperandrogenism: a case-control study
title_fullStr	Elevated plasma pentraxin-3 in polycystic ovary syndrome is associated with hyperandrogenism: a case-control study
title_full_unstemmed	Elevated plasma pentraxin-3 in polycystic ovary syndrome is associated with hyperandrogenism: a case-control study
title_sort	elevated plasma pentraxin-3 in polycystic ovary syndrome is associated with hyperandrogenism: a case-control study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/639fd9adb8ac4ee1908bac5e1b1f379d
work_keys_str_mv	AT congcongjin elevatedplasmapentraxin3inpolycysticovarysyndromeisassociatedwithhyperandrogenismacasecontrolstudy AT kexinzou elevatedplasmapentraxin3inpolycysticovarysyndromeisassociatedwithhyperandrogenismacasecontrolstudy AT yuexu elevatedplasmapentraxin3inpolycysticovarysyndromeisassociatedwithhyperandrogenismacasecontrolstudy AT haiyanyang elevatedplasmapentraxin3inpolycysticovarysyndromeisassociatedwithhyperandrogenismacasecontrolstudy AT jiexuepan elevatedplasmapentraxin3inpolycysticovarysyndromeisassociatedwithhyperandrogenismacasecontrolstudy
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Elevated plasma pentraxin-3 in polycystic ovary syndrome is associated with hyperandrogenism: a case-control study

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