Importance of medication adherence in treatment needed diabetic retinopathy

Abstract We aim to investigate the role of medication adherence history in treatment needed diabetic retinopathy (TNDR). We conducted a retrospective nested case–control study using 3 population-based databases in Taiwan. The major one was the 2-million-sample longitudinal health and welfare populat...

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Autores principales:	Chia-Chen Kao, Hui-Min Hsieh, Daniel Yu Lee, Kun-Pin Hsieh, Shwu-Jiuan Sheu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/63a003a72cbf433ba2107a256284279b
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spelling	oai:doaj.org-article:63a003a72cbf433ba2107a256284279b2021-12-02T17:18:22ZImportance of medication adherence in treatment needed diabetic retinopathy10.1038/s41598-021-98488-62045-2322https://doaj.org/article/63a003a72cbf433ba2107a256284279b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98488-6https://doaj.org/toc/2045-2322Abstract We aim to investigate the role of medication adherence history in treatment needed diabetic retinopathy (TNDR). We conducted a retrospective nested case–control study using 3 population-based databases in Taiwan. The major one was the 2-million-sample longitudinal health and welfare population-based database from 1997 to 2017, a nationally representative random sample of National Health Insurance Administration enrolled beneficiaries in 2010 (LHID2010). The national death registry and national cancer registry were also checked to verify the information. The outcome was defined as the TNDR. The Medication possession ratio (MPR) was defined as the ratio of total days of diabetes mellitus (DM) medication supply divided by total observation days. MPR ≥ 80% was proposed as good medication adherence. The association of MPR and the TNDR was analyzed. Other potential confounders and MPR ratio were also evaluated. A total of (n = 44,628) patients were enrolled. Younger aged, male sex and patients with less chronic illness complexity or less diabetes complication severity tend to have poorer medication adherence. Those with severe comorbidity or participating pay-for-performance program (P4P) revealed better adherence. No matter what the characteristics are, patients with good MPR showed a significantly lower likelihood of leading to TNDR after adjustment with other factors. The protection effect was consistent for up to 5 years. Good medication adherence significantly prevents treatment needed diabetic retinopathy. Hence, it is important to promote DM medication adherence to prevent risks of diabetic retinopathy progression, especially those who opt to have low medication adherence.Chia-Chen KaoHui-Min HsiehDaniel Yu LeeKun-Pin HsiehShwu-Jiuan SheuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chia-Chen Kao Hui-Min Hsieh Daniel Yu Lee Kun-Pin Hsieh Shwu-Jiuan Sheu Importance of medication adherence in treatment needed diabetic retinopathy
description	Abstract We aim to investigate the role of medication adherence history in treatment needed diabetic retinopathy (TNDR). We conducted a retrospective nested case–control study using 3 population-based databases in Taiwan. The major one was the 2-million-sample longitudinal health and welfare population-based database from 1997 to 2017, a nationally representative random sample of National Health Insurance Administration enrolled beneficiaries in 2010 (LHID2010). The national death registry and national cancer registry were also checked to verify the information. The outcome was defined as the TNDR. The Medication possession ratio (MPR) was defined as the ratio of total days of diabetes mellitus (DM) medication supply divided by total observation days. MPR ≥ 80% was proposed as good medication adherence. The association of MPR and the TNDR was analyzed. Other potential confounders and MPR ratio were also evaluated. A total of (n = 44,628) patients were enrolled. Younger aged, male sex and patients with less chronic illness complexity or less diabetes complication severity tend to have poorer medication adherence. Those with severe comorbidity or participating pay-for-performance program (P4P) revealed better adherence. No matter what the characteristics are, patients with good MPR showed a significantly lower likelihood of leading to TNDR after adjustment with other factors. The protection effect was consistent for up to 5 years. Good medication adherence significantly prevents treatment needed diabetic retinopathy. Hence, it is important to promote DM medication adherence to prevent risks of diabetic retinopathy progression, especially those who opt to have low medication adherence.
format	article
author	Chia-Chen Kao Hui-Min Hsieh Daniel Yu Lee Kun-Pin Hsieh Shwu-Jiuan Sheu
author_facet	Chia-Chen Kao Hui-Min Hsieh Daniel Yu Lee Kun-Pin Hsieh Shwu-Jiuan Sheu
author_sort	Chia-Chen Kao
title	Importance of medication adherence in treatment needed diabetic retinopathy
title_short	Importance of medication adherence in treatment needed diabetic retinopathy
title_full	Importance of medication adherence in treatment needed diabetic retinopathy
title_fullStr	Importance of medication adherence in treatment needed diabetic retinopathy
title_full_unstemmed	Importance of medication adherence in treatment needed diabetic retinopathy
title_sort	importance of medication adherence in treatment needed diabetic retinopathy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/63a003a72cbf433ba2107a256284279b
work_keys_str_mv	AT chiachenkao importanceofmedicationadherenceintreatmentneededdiabeticretinopathy AT huiminhsieh importanceofmedicationadherenceintreatmentneededdiabeticretinopathy AT danielyulee importanceofmedicationadherenceintreatmentneededdiabeticretinopathy AT kunpinhsieh importanceofmedicationadherenceintreatmentneededdiabeticretinopathy AT shwujiuansheu importanceofmedicationadherenceintreatmentneededdiabeticretinopathy
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Importance of medication adherence in treatment needed diabetic retinopathy

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