SYSTEMIC ANTIBODY AND CELLULAR IMMUNE RESPONSES IN INFLUENZA INFECTION AND POSTSVACCINATION

Abstract. Post-infection immunity represents an immunogenicity standard for antiviral vaccines, including those against influenza. To estimate the immunogenic properties of vaccine preparations, it is necessary to compare the quantitative and qualitative parameters of immune responses to the vaccine...

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Autores principales:	S. A. Donina, A. N. Naikhin, G. D. Petukhova, I. B. Barantseva, T. V. Chirkova, Е. P. Grigor’eva, А. R. Rekstin, L. G. Rudenko
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	systemic immune responses influenza vaccination Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/63a2ae7c42e244b8a35ab0f4a8b9a66c
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spelling	oai:doaj.org-article:63a2ae7c42e244b8a35ab0f4a8b9a66c2021-11-18T08:03:41ZSYSTEMIC ANTIBODY AND CELLULAR IMMUNE RESPONSES IN INFLUENZA INFECTION AND POSTSVACCINATION1563-06252313-741X10.15789/1563-0625-2006-1-31-36https://doaj.org/article/63a2ae7c42e244b8a35ab0f4a8b9a66c2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/419https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Post-infection immunity represents an immunogenicity standard for antiviral vaccines, including those against influenza. To estimate the immunogenic properties of vaccine preparations, it is necessary to compare the quantitative and qualitative parameters of immune responses to the vaccine strain and the virulent virus from which it is prepared. However, for ethical reasons, such human studies are difficult, because there is the possibility of pathogenic viral infection.The aim of this experimental work was to compare systemic immune responses to the pathogenic mouse influenza virus A (H1N1), and an attenuated reassortant virus, genetic formula 2/6 (R 2/6), an experimental analogue to the live influenza vaccine.It was shown, that R 2/6 lagged behind the pathogenic parental virus (PPV) in activated induction of circulating IgG-antibodies, secretion of a marker Th1-cytokine IFN-γ by splenocytes, and CTL (CD8+) production in the spleen. On the other hand, R 2/6 was highly competitive with PPV, with regard to quantitative proliferative parameters of pooled splenocytes, stimulation of Th (CD4+) cells, B-cells (CD19+), and Th2-cytokine IL-2. IL-6 production in the spleen was poorly induced by both viruses.Thus, attenuation of influenza A (H1N1) virus by the 2/6 genetic reassortment differentially influences the induction of systemic immunity constituents. i.e., some parameters of immune response may be reduced, while others are not altered. When preparing vaccine strains for live influenza vaccines, an attention should be given first of all to increased induction of circulating antibodies that comprise the major components of antiviral immunity.S. A. DoninaA. N. NaikhinG. D. PetukhovaI. B. BarantsevaT. V. ChirkovaЕ. P. Grigor’evaА. R. RekstinL. G. RudenkoSPb RAACIarticlesystemic immune responsesinfluenzavaccinationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 8, Iss 1, Pp 31-36 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	systemic immune responses influenza vaccination Immunologic diseases. Allergy RC581-607
spellingShingle	systemic immune responses influenza vaccination Immunologic diseases. Allergy RC581-607 S. A. Donina A. N. Naikhin G. D. Petukhova I. B. Barantseva T. V. Chirkova Е. P. Grigor’eva А. R. Rekstin L. G. Rudenko SYSTEMIC ANTIBODY AND CELLULAR IMMUNE RESPONSES IN INFLUENZA INFECTION AND POSTSVACCINATION
description	Abstract. Post-infection immunity represents an immunogenicity standard for antiviral vaccines, including those against influenza. To estimate the immunogenic properties of vaccine preparations, it is necessary to compare the quantitative and qualitative parameters of immune responses to the vaccine strain and the virulent virus from which it is prepared. However, for ethical reasons, such human studies are difficult, because there is the possibility of pathogenic viral infection.The aim of this experimental work was to compare systemic immune responses to the pathogenic mouse influenza virus A (H1N1), and an attenuated reassortant virus, genetic formula 2/6 (R 2/6), an experimental analogue to the live influenza vaccine.It was shown, that R 2/6 lagged behind the pathogenic parental virus (PPV) in activated induction of circulating IgG-antibodies, secretion of a marker Th1-cytokine IFN-γ by splenocytes, and CTL (CD8+) production in the spleen. On the other hand, R 2/6 was highly competitive with PPV, with regard to quantitative proliferative parameters of pooled splenocytes, stimulation of Th (CD4+) cells, B-cells (CD19+), and Th2-cytokine IL-2. IL-6 production in the spleen was poorly induced by both viruses.Thus, attenuation of influenza A (H1N1) virus by the 2/6 genetic reassortment differentially influences the induction of systemic immunity constituents. i.e., some parameters of immune response may be reduced, while others are not altered. When preparing vaccine strains for live influenza vaccines, an attention should be given first of all to increased induction of circulating antibodies that comprise the major components of antiviral immunity.
format	article
author	S. A. Donina A. N. Naikhin G. D. Petukhova I. B. Barantseva T. V. Chirkova Е. P. Grigor’eva А. R. Rekstin L. G. Rudenko
author_facet	S. A. Donina A. N. Naikhin G. D. Petukhova I. B. Barantseva T. V. Chirkova Е. P. Grigor’eva А. R. Rekstin L. G. Rudenko
author_sort	S. A. Donina
title	SYSTEMIC ANTIBODY AND CELLULAR IMMUNE RESPONSES IN INFLUENZA INFECTION AND POSTSVACCINATION
title_short	SYSTEMIC ANTIBODY AND CELLULAR IMMUNE RESPONSES IN INFLUENZA INFECTION AND POSTSVACCINATION
title_full	SYSTEMIC ANTIBODY AND CELLULAR IMMUNE RESPONSES IN INFLUENZA INFECTION AND POSTSVACCINATION
title_fullStr	SYSTEMIC ANTIBODY AND CELLULAR IMMUNE RESPONSES IN INFLUENZA INFECTION AND POSTSVACCINATION
title_full_unstemmed	SYSTEMIC ANTIBODY AND CELLULAR IMMUNE RESPONSES IN INFLUENZA INFECTION AND POSTSVACCINATION
title_sort	systemic antibody and cellular immune responses in influenza infection and postsvaccination
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/63a2ae7c42e244b8a35ab0f4a8b9a66c
work_keys_str_mv	AT sadonina systemicantibodyandcellularimmuneresponsesininfluenzainfectionandpostsvaccination AT annaikhin systemicantibodyandcellularimmuneresponsesininfluenzainfectionandpostsvaccination AT gdpetukhova systemicantibodyandcellularimmuneresponsesininfluenzainfectionandpostsvaccination AT ibbarantseva systemicantibodyandcellularimmuneresponsesininfluenzainfectionandpostsvaccination AT tvchirkova systemicantibodyandcellularimmuneresponsesininfluenzainfectionandpostsvaccination AT epgrigoreva systemicantibodyandcellularimmuneresponsesininfluenzainfectionandpostsvaccination AT arrekstin systemicantibodyandcellularimmuneresponsesininfluenzainfectionandpostsvaccination AT lgrudenko systemicantibodyandcellularimmuneresponsesininfluenzainfectionandpostsvaccination
_version_	1718422479551070208

SYSTEMIC ANTIBODY AND CELLULAR IMMUNE RESPONSES IN INFLUENZA INFECTION AND POSTSVACCINATION

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