Clinical application of patient-specific 3D printing brain tumor model production system for neurosurgery

Abstract The usefulness of 3-dimensional (3D)-printed disease models has been recognized in various medical fields. This study aims to introduce a production platform for patient-specific 3D-printed brain tumor model in clinical practice and evaluate its effectiveness. A full-cycle platform was crea...

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Autores principales:	Yun-Sik Dho, Doohee Lee, Teahyun Ha, So Young Ji, Kyung Min Kim, Ho Kang, Min-Sung Kim, Jin Wook Kim, Won-Sang Cho, Yong Hwy Kim, Young Gyu Kim, Sang Joon Park, Chul-Kee Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/63a40bd5cf7247789f4d53816de2665e
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spelling	oai:doaj.org-article:63a40bd5cf7247789f4d53816de2665e2021-12-02T11:45:02ZClinical application of patient-specific 3D printing brain tumor model production system for neurosurgery10.1038/s41598-021-86546-y2045-2322https://doaj.org/article/63a40bd5cf7247789f4d53816de2665e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86546-yhttps://doaj.org/toc/2045-2322Abstract The usefulness of 3-dimensional (3D)-printed disease models has been recognized in various medical fields. This study aims to introduce a production platform for patient-specific 3D-printed brain tumor model in clinical practice and evaluate its effectiveness. A full-cycle platform was created for the clinical application of a 3D-printed brain tumor model (3D-printed model) production system. Essential elements included automated segmentation software, cloud-based interactive communication tools, customized brain models with exquisite expression of brain anatomy in transparent material, adjunctive devices for surgical simulation, and swift process cycles to meet practical needs. A simulated clinical usefulness validation was conducted in which neurosurgeons assessed the usefulness of the 3D-printed models in 10 cases. We successfully produced clinically applicable patient-specific models within 4 days using the established platform. The simulated clinical usefulness validation results revealed the significant superiority of the 3D-printed models in surgical planning regarding surgical posture (p = 0.0147) and craniotomy design (p = 0.0072) compared to conventional magnetic resonance images. The benefit was more noticeable for neurosurgeons with less experience. We established a 3D-printed brain tumor model production system that is ready to use in daily clinical practice for neurosurgery.Yun-Sik DhoDoohee LeeTeahyun HaSo Young JiKyung Min KimHo KangMin-Sung KimJin Wook KimWon-Sang ChoYong Hwy KimYoung Gyu KimSang Joon ParkChul-Kee ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yun-Sik Dho Doohee Lee Teahyun Ha So Young Ji Kyung Min Kim Ho Kang Min-Sung Kim Jin Wook Kim Won-Sang Cho Yong Hwy Kim Young Gyu Kim Sang Joon Park Chul-Kee Park Clinical application of patient-specific 3D printing brain tumor model production system for neurosurgery
description	Abstract The usefulness of 3-dimensional (3D)-printed disease models has been recognized in various medical fields. This study aims to introduce a production platform for patient-specific 3D-printed brain tumor model in clinical practice and evaluate its effectiveness. A full-cycle platform was created for the clinical application of a 3D-printed brain tumor model (3D-printed model) production system. Essential elements included automated segmentation software, cloud-based interactive communication tools, customized brain models with exquisite expression of brain anatomy in transparent material, adjunctive devices for surgical simulation, and swift process cycles to meet practical needs. A simulated clinical usefulness validation was conducted in which neurosurgeons assessed the usefulness of the 3D-printed models in 10 cases. We successfully produced clinically applicable patient-specific models within 4 days using the established platform. The simulated clinical usefulness validation results revealed the significant superiority of the 3D-printed models in surgical planning regarding surgical posture (p = 0.0147) and craniotomy design (p = 0.0072) compared to conventional magnetic resonance images. The benefit was more noticeable for neurosurgeons with less experience. We established a 3D-printed brain tumor model production system that is ready to use in daily clinical practice for neurosurgery.
format	article
author	Yun-Sik Dho Doohee Lee Teahyun Ha So Young Ji Kyung Min Kim Ho Kang Min-Sung Kim Jin Wook Kim Won-Sang Cho Yong Hwy Kim Young Gyu Kim Sang Joon Park Chul-Kee Park
author_facet	Yun-Sik Dho Doohee Lee Teahyun Ha So Young Ji Kyung Min Kim Ho Kang Min-Sung Kim Jin Wook Kim Won-Sang Cho Yong Hwy Kim Young Gyu Kim Sang Joon Park Chul-Kee Park
author_sort	Yun-Sik Dho
title	Clinical application of patient-specific 3D printing brain tumor model production system for neurosurgery
title_short	Clinical application of patient-specific 3D printing brain tumor model production system for neurosurgery
title_full	Clinical application of patient-specific 3D printing brain tumor model production system for neurosurgery
title_fullStr	Clinical application of patient-specific 3D printing brain tumor model production system for neurosurgery
title_full_unstemmed	Clinical application of patient-specific 3D printing brain tumor model production system for neurosurgery
title_sort	clinical application of patient-specific 3d printing brain tumor model production system for neurosurgery
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/63a40bd5cf7247789f4d53816de2665e
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Clinical application of patient-specific 3D printing brain tumor model production system for neurosurgery

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