Interleukin-27 is differentially associated with HIV viral load and CD4+ T cell counts in therapy-naïve HIV-mono-infected and HIV/HCV-co-infected Chinese.

Human Immunodeficiency Virus (HIV) infection and the resultant Acquired Immunodeficiency Syndrome (AIDS) epidemic are major global health challenges; hepatitis C virus (HCV) co-infection has made the HIV/AIDS epidemic even worse. Interleukin-27 (IL-27), a cytokine which inhibits HIV and HCV replicat...

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Autores principales: Lai He, Jin Zhao, Maggie Haitian Wang, Kenny K Y Siu, Yong-Xia Gan, Lin Chen, Benny C Y Zee, Li Yang, Hsiang-Fu Kung, Zheng-Rong Yang, Ming-Liang He
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Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/63a47b65f2ca48999e6050855ffa001c
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spelling oai:doaj.org-article:63a47b65f2ca48999e6050855ffa001c2021-11-18T08:19:54ZInterleukin-27 is differentially associated with HIV viral load and CD4+ T cell counts in therapy-naïve HIV-mono-infected and HIV/HCV-co-infected Chinese.1932-620310.1371/journal.pone.0096792https://doaj.org/article/63a47b65f2ca48999e6050855ffa001c2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24816922/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Human Immunodeficiency Virus (HIV) infection and the resultant Acquired Immunodeficiency Syndrome (AIDS) epidemic are major global health challenges; hepatitis C virus (HCV) co-infection has made the HIV/AIDS epidemic even worse. Interleukin-27 (IL-27), a cytokine which inhibits HIV and HCV replication in vitro, associates with HIV infection and HIV/HCV co-infection in clinical settings. However, the impact of HIV and HCV viral loads on plasma IL-27 expression levels has not been well characterized. In this study, 155 antiretroviral therapy-naïve Chinese were recruited. Among them 80 were HIV- and HCV-negative healthy controls, 45 were HIV-mono-infected and 30 were HIV/HCV-co-infected. Plasma level HIV, HCV, IL-27 and CD4+ number were counted and their correlation, regression relationships were explored. We show that: plasma IL-27 level was significantly upregulated in HIV-mono-infected and HIV/HCV-co-infected Chinese; HIV viral load was negatively correlated with IL-27 titer in HIV-mono-infected subjects whereas the relationship was opposite in HIV/HCV-co-infected subjects; and the relationships between HIV viral loads, IL-27 titers and CD4+ T cell counts in the HIV mono-infection and HIV/HCV co-infection groups were dramatically different. Overall, our results suggest that IL-27 differs in treatment-naïve groups with HIV mono-infections and HIV/HCV co-infections, thereby providing critical information to be considered when caring and treating those with HIV mono-infection and HIV/HCV co-infection.Lai HeJin ZhaoMaggie Haitian WangKenny K Y SiuYong-Xia GanLin ChenBenny C Y ZeeLi YangHsiang-Fu KungZheng-Rong YangMing-Liang HePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e96792 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Lai He
Jin Zhao
Maggie Haitian Wang
Kenny K Y Siu
Yong-Xia Gan
Lin Chen
Benny C Y Zee
Li Yang
Hsiang-Fu Kung
Zheng-Rong Yang
Ming-Liang He
Interleukin-27 is differentially associated with HIV viral load and CD4+ T cell counts in therapy-naïve HIV-mono-infected and HIV/HCV-co-infected Chinese.
description Human Immunodeficiency Virus (HIV) infection and the resultant Acquired Immunodeficiency Syndrome (AIDS) epidemic are major global health challenges; hepatitis C virus (HCV) co-infection has made the HIV/AIDS epidemic even worse. Interleukin-27 (IL-27), a cytokine which inhibits HIV and HCV replication in vitro, associates with HIV infection and HIV/HCV co-infection in clinical settings. However, the impact of HIV and HCV viral loads on plasma IL-27 expression levels has not been well characterized. In this study, 155 antiretroviral therapy-naïve Chinese were recruited. Among them 80 were HIV- and HCV-negative healthy controls, 45 were HIV-mono-infected and 30 were HIV/HCV-co-infected. Plasma level HIV, HCV, IL-27 and CD4+ number were counted and their correlation, regression relationships were explored. We show that: plasma IL-27 level was significantly upregulated in HIV-mono-infected and HIV/HCV-co-infected Chinese; HIV viral load was negatively correlated with IL-27 titer in HIV-mono-infected subjects whereas the relationship was opposite in HIV/HCV-co-infected subjects; and the relationships between HIV viral loads, IL-27 titers and CD4+ T cell counts in the HIV mono-infection and HIV/HCV co-infection groups were dramatically different. Overall, our results suggest that IL-27 differs in treatment-naïve groups with HIV mono-infections and HIV/HCV co-infections, thereby providing critical information to be considered when caring and treating those with HIV mono-infection and HIV/HCV co-infection.
format article
author Lai He
Jin Zhao
Maggie Haitian Wang
Kenny K Y Siu
Yong-Xia Gan
Lin Chen
Benny C Y Zee
Li Yang
Hsiang-Fu Kung
Zheng-Rong Yang
Ming-Liang He
author_facet Lai He
Jin Zhao
Maggie Haitian Wang
Kenny K Y Siu
Yong-Xia Gan
Lin Chen
Benny C Y Zee
Li Yang
Hsiang-Fu Kung
Zheng-Rong Yang
Ming-Liang He
author_sort Lai He
title Interleukin-27 is differentially associated with HIV viral load and CD4+ T cell counts in therapy-naïve HIV-mono-infected and HIV/HCV-co-infected Chinese.
title_short Interleukin-27 is differentially associated with HIV viral load and CD4+ T cell counts in therapy-naïve HIV-mono-infected and HIV/HCV-co-infected Chinese.
title_full Interleukin-27 is differentially associated with HIV viral load and CD4+ T cell counts in therapy-naïve HIV-mono-infected and HIV/HCV-co-infected Chinese.
title_fullStr Interleukin-27 is differentially associated with HIV viral load and CD4+ T cell counts in therapy-naïve HIV-mono-infected and HIV/HCV-co-infected Chinese.
title_full_unstemmed Interleukin-27 is differentially associated with HIV viral load and CD4+ T cell counts in therapy-naïve HIV-mono-infected and HIV/HCV-co-infected Chinese.
title_sort interleukin-27 is differentially associated with hiv viral load and cd4+ t cell counts in therapy-naïve hiv-mono-infected and hiv/hcv-co-infected chinese.
publisher Public Library of Science (PLoS)
publishDate 2014
url https://doaj.org/article/63a47b65f2ca48999e6050855ffa001c
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