Sensory capability and information integration independently explain the cognitive status of healthy older adults

Abstract While there is evidence that sensory processing and multisensory integration change with age, links between these alterations and their relation to cognitive status remain unclear. In this study, we assessed sensory thresholds and performance of healthy younger and older adults in a visuota...

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Autores principales:	Jonas Misselhorn, Florian Göschl, Focko L. Higgen, Friedhelm C. Hummel, Christian Gerloff, Andreas K. Engel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/63a6c5f2efd94350b7246c6fc1cd8ca4
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spelling	oai:doaj.org-article:63a6c5f2efd94350b7246c6fc1cd8ca42021-12-02T15:12:47ZSensory capability and information integration independently explain the cognitive status of healthy older adults10.1038/s41598-020-80069-82045-2322https://doaj.org/article/63a6c5f2efd94350b7246c6fc1cd8ca42020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80069-8https://doaj.org/toc/2045-2322Abstract While there is evidence that sensory processing and multisensory integration change with age, links between these alterations and their relation to cognitive status remain unclear. In this study, we assessed sensory thresholds and performance of healthy younger and older adults in a visuotactile delayed match-to-sample task. Using Bayesian structural equation modelling (BSEM), we explored the factors explaining cognitive status in the group of older adults. Additionally, we applied transcranial alternating current stimulation (tACS) to a parieto-central network found to underlie visuotactile interactions and working memory matching in our previous work. Response times and signal detection measures indicated enhanced multisensory integration and enhanced benefit from successful working memory matching in older adults. Further, tACS caused a frequency-specific speeding (20 Hz) and delaying (70 Hz) of responses. Data exploration suggested distinct underlying factors for sensory acuity and sensitivity d’ on the one side, and multisensory and working memory enhancement on the other side. Finally, BSEM showed that these two factors labelled ‘sensory capability’ and ‘information integration’ independently explained cognitive status. We conclude that sensory decline and enhanced information integration might relate to distinct processes of ageing and discuss a potential role of the parietal cortex in mediating augmented integration in older adults.Jonas MisselhornFlorian GöschlFocko L. HiggenFriedhelm C. HummelChristian GerloffAndreas K. EngelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jonas Misselhorn Florian Göschl Focko L. Higgen Friedhelm C. Hummel Christian Gerloff Andreas K. Engel Sensory capability and information integration independently explain the cognitive status of healthy older adults
description	Abstract While there is evidence that sensory processing and multisensory integration change with age, links between these alterations and their relation to cognitive status remain unclear. In this study, we assessed sensory thresholds and performance of healthy younger and older adults in a visuotactile delayed match-to-sample task. Using Bayesian structural equation modelling (BSEM), we explored the factors explaining cognitive status in the group of older adults. Additionally, we applied transcranial alternating current stimulation (tACS) to a parieto-central network found to underlie visuotactile interactions and working memory matching in our previous work. Response times and signal detection measures indicated enhanced multisensory integration and enhanced benefit from successful working memory matching in older adults. Further, tACS caused a frequency-specific speeding (20 Hz) and delaying (70 Hz) of responses. Data exploration suggested distinct underlying factors for sensory acuity and sensitivity d’ on the one side, and multisensory and working memory enhancement on the other side. Finally, BSEM showed that these two factors labelled ‘sensory capability’ and ‘information integration’ independently explained cognitive status. We conclude that sensory decline and enhanced information integration might relate to distinct processes of ageing and discuss a potential role of the parietal cortex in mediating augmented integration in older adults.
format	article
author	Jonas Misselhorn Florian Göschl Focko L. Higgen Friedhelm C. Hummel Christian Gerloff Andreas K. Engel
author_facet	Jonas Misselhorn Florian Göschl Focko L. Higgen Friedhelm C. Hummel Christian Gerloff Andreas K. Engel
author_sort	Jonas Misselhorn
title	Sensory capability and information integration independently explain the cognitive status of healthy older adults
title_short	Sensory capability and information integration independently explain the cognitive status of healthy older adults
title_full	Sensory capability and information integration independently explain the cognitive status of healthy older adults
title_fullStr	Sensory capability and information integration independently explain the cognitive status of healthy older adults
title_full_unstemmed	Sensory capability and information integration independently explain the cognitive status of healthy older adults
title_sort	sensory capability and information integration independently explain the cognitive status of healthy older adults
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/63a6c5f2efd94350b7246c6fc1cd8ca4
work_keys_str_mv	AT jonasmisselhorn sensorycapabilityandinformationintegrationindependentlyexplainthecognitivestatusofhealthyolderadults AT floriangoschl sensorycapabilityandinformationintegrationindependentlyexplainthecognitivestatusofhealthyolderadults AT fockolhiggen sensorycapabilityandinformationintegrationindependentlyexplainthecognitivestatusofhealthyolderadults AT friedhelmchummel sensorycapabilityandinformationintegrationindependentlyexplainthecognitivestatusofhealthyolderadults AT christiangerloff sensorycapabilityandinformationintegrationindependentlyexplainthecognitivestatusofhealthyolderadults AT andreaskengel sensorycapabilityandinformationintegrationindependentlyexplainthecognitivestatusofhealthyolderadults
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Sensory capability and information integration independently explain the cognitive status of healthy older adults

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