INTERRELATIONS BETWEEN IMMUNOLOGICAL ALTERATIONS AND VIRAL LOAD IN ACUTE HEPATITIS B

Abstract. A group of seventy-six patients with acute viral hepatitis B (HB) was under study, in order to evaluate immunological parameters, and ability of blood mononuclear cells to produce cytokines, as dependent on individual viral loads. The immune parameters were less affected in cases of low vi...

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Autores principales:	A. A. Savchenko, V. V. Tsukanov, D. V. Rodina, A. G. Borisov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	hepatitis b immune profile interferon-γ tumor necrosis factor-α production levels Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/63a92d3f65db49618d28b2a0528da252
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spelling	oai:doaj.org-article:63a92d3f65db49618d28b2a0528da2522021-11-18T08:03:42ZINTERRELATIONS BETWEEN IMMUNOLOGICAL ALTERATIONS AND VIRAL LOAD IN ACUTE HEPATITIS B1563-06252313-741X10.15789/1563-0625-2011-2-3-181-188https://doaj.org/article/63a92d3f65db49618d28b2a0528da2522014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/518https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. A group of seventy-six patients with acute viral hepatitis B (HB) was under study, in order to evaluate immunological parameters, and ability of blood mononuclear cells to produce cytokines, as dependent on individual viral loads. The immune parameters were less affected in cases of low viral load. Meanwhile, the immune profiles exhibited maximal alterations in the patients with medium and high viral loads. Most expressed changes of immune parameters are found in patients with moderate and high virus load. Meanwhile, moderate HB viral loads are associated with higher functional activity of B-cells and lower NK numbers, whereas high viral loads correlated with increased amounts of peripheral B cells and higher CD25+ lymphocyte levels. Increased background cytokine synthesis is revealed in mononuclear cells of the patients with acute HB, being, however, suppressed upon additional functional induction. An increased viral load is associated with decreased basal levels of TNFα synthesis. (Med. Immunol., 2011, vol. 13, N 2-3, pp 181-188)A. A. SavchenkoV. V. TsukanovD. V. RodinaA. G. BorisovSPb RAACIarticlehepatitis bimmune profileinterferon-γtumor necrosis factor-αproduction levelsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 2-3, Pp 181-188 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	hepatitis b immune profile interferon-γ tumor necrosis factor-α production levels Immunologic diseases. Allergy RC581-607
spellingShingle	hepatitis b immune profile interferon-γ tumor necrosis factor-α production levels Immunologic diseases. Allergy RC581-607 A. A. Savchenko V. V. Tsukanov D. V. Rodina A. G. Borisov INTERRELATIONS BETWEEN IMMUNOLOGICAL ALTERATIONS AND VIRAL LOAD IN ACUTE HEPATITIS B
description	Abstract. A group of seventy-six patients with acute viral hepatitis B (HB) was under study, in order to evaluate immunological parameters, and ability of blood mononuclear cells to produce cytokines, as dependent on individual viral loads. The immune parameters were less affected in cases of low viral load. Meanwhile, the immune profiles exhibited maximal alterations in the patients with medium and high viral loads. Most expressed changes of immune parameters are found in patients with moderate and high virus load. Meanwhile, moderate HB viral loads are associated with higher functional activity of B-cells and lower NK numbers, whereas high viral loads correlated with increased amounts of peripheral B cells and higher CD25+ lymphocyte levels. Increased background cytokine synthesis is revealed in mononuclear cells of the patients with acute HB, being, however, suppressed upon additional functional induction. An increased viral load is associated with decreased basal levels of TNFα synthesis. (Med. Immunol., 2011, vol. 13, N 2-3, pp 181-188)
format	article
author	A. A. Savchenko V. V. Tsukanov D. V. Rodina A. G. Borisov
author_facet	A. A. Savchenko V. V. Tsukanov D. V. Rodina A. G. Borisov
author_sort	A. A. Savchenko
title	INTERRELATIONS BETWEEN IMMUNOLOGICAL ALTERATIONS AND VIRAL LOAD IN ACUTE HEPATITIS B
title_short	INTERRELATIONS BETWEEN IMMUNOLOGICAL ALTERATIONS AND VIRAL LOAD IN ACUTE HEPATITIS B
title_full	INTERRELATIONS BETWEEN IMMUNOLOGICAL ALTERATIONS AND VIRAL LOAD IN ACUTE HEPATITIS B
title_fullStr	INTERRELATIONS BETWEEN IMMUNOLOGICAL ALTERATIONS AND VIRAL LOAD IN ACUTE HEPATITIS B
title_full_unstemmed	INTERRELATIONS BETWEEN IMMUNOLOGICAL ALTERATIONS AND VIRAL LOAD IN ACUTE HEPATITIS B
title_sort	interrelations between immunological alterations and viral load in acute hepatitis b
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/63a92d3f65db49618d28b2a0528da252
work_keys_str_mv	AT aasavchenko interrelationsbetweenimmunologicalalterationsandviralloadinacutehepatitisb AT vvtsukanov interrelationsbetweenimmunologicalalterationsandviralloadinacutehepatitisb AT dvrodina interrelationsbetweenimmunologicalalterationsandviralloadinacutehepatitisb AT agborisov interrelationsbetweenimmunologicalalterationsandviralloadinacutehepatitisb
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INTERRELATIONS BETWEEN IMMUNOLOGICAL ALTERATIONS AND VIRAL LOAD IN ACUTE HEPATITIS B

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