Large-scale systematic analysis of exposure to multiple cancer risk factors and the associations between exposure patterns and cancer incidence

Abstract Exposures to cancer risk factors such as smoking and alcohol are not mutually independent. We aimed to identify risk factor exposure patterns and their associations with sociodemographic characteristics and cancer incidence. We considered 120,771 female and, separately, 100,891 male partici...

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Autores principales:	Julia Steinberg, Sarsha Yap, David Goldsbury, Visalini Nair-Shalliker, Emily Banks, Karen Canfell, Dianne L. O’Connell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/63a95785e4fb45599a21ea253910284c
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spelling	oai:doaj.org-article:63a95785e4fb45599a21ea253910284c2021-12-02T13:24:07ZLarge-scale systematic analysis of exposure to multiple cancer risk factors and the associations between exposure patterns and cancer incidence10.1038/s41598-021-81463-62045-2322https://doaj.org/article/63a95785e4fb45599a21ea253910284c2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81463-6https://doaj.org/toc/2045-2322Abstract Exposures to cancer risk factors such as smoking and alcohol are not mutually independent. We aimed to identify risk factor exposure patterns and their associations with sociodemographic characteristics and cancer incidence. We considered 120,771 female and, separately, 100,891 male participants of the Australian prospective cohort 45 and Up Study. Factor analysis grouped 36 self-reported variables into 8 combined factors each for females (largely representing ‘smoking’, ‘alcohol’, ‘vigorous exercise’, ‘age at childbirth’, ‘Menopausal Hormone Therapy’, ‘parity and breastfeeding’, ‘standing/sitting’, ‘fruit and vegetables’) and males (largely representing ‘smoking’, ‘alcohol’, ‘vigorous exercise’, ‘urology and health’, ‘moderate exercise’, ‘standing/sitting’, ‘fruit and vegetables’, ‘meat and BMI’). Associations with cancer incidence were investigated using multivariable logistic regression (4–8 years follow-up: 6193 females, 8749 males diagnosed with cancer). After multiple-testing correction, we identified 10 associations between combined factors and cancer incidence for females and 6 for males, of which 14 represent well-known relationships (e.g. bowel cancer: females ‘smoking’ factor Odds Ratio (OR) 1.16 (95% Confidence Interval (CI) 1.08–1.25), males ‘smoking’ factor OR 1.15 (95% CI 1.07–1.23)), providing evidence for the validity of this approach. The catalogue of associations between exposure patterns, sociodemographic characteristics, and cancer incidence can help inform design of future studies and targeted prevention programmes.Julia SteinbergSarsha YapDavid GoldsburyVisalini Nair-ShallikerEmily BanksKaren CanfellDianne L. O’ConnellNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julia Steinberg Sarsha Yap David Goldsbury Visalini Nair-Shalliker Emily Banks Karen Canfell Dianne L. O’Connell Large-scale systematic analysis of exposure to multiple cancer risk factors and the associations between exposure patterns and cancer incidence
description	Abstract Exposures to cancer risk factors such as smoking and alcohol are not mutually independent. We aimed to identify risk factor exposure patterns and their associations with sociodemographic characteristics and cancer incidence. We considered 120,771 female and, separately, 100,891 male participants of the Australian prospective cohort 45 and Up Study. Factor analysis grouped 36 self-reported variables into 8 combined factors each for females (largely representing ‘smoking’, ‘alcohol’, ‘vigorous exercise’, ‘age at childbirth’, ‘Menopausal Hormone Therapy’, ‘parity and breastfeeding’, ‘standing/sitting’, ‘fruit and vegetables’) and males (largely representing ‘smoking’, ‘alcohol’, ‘vigorous exercise’, ‘urology and health’, ‘moderate exercise’, ‘standing/sitting’, ‘fruit and vegetables’, ‘meat and BMI’). Associations with cancer incidence were investigated using multivariable logistic regression (4–8 years follow-up: 6193 females, 8749 males diagnosed with cancer). After multiple-testing correction, we identified 10 associations between combined factors and cancer incidence for females and 6 for males, of which 14 represent well-known relationships (e.g. bowel cancer: females ‘smoking’ factor Odds Ratio (OR) 1.16 (95% Confidence Interval (CI) 1.08–1.25), males ‘smoking’ factor OR 1.15 (95% CI 1.07–1.23)), providing evidence for the validity of this approach. The catalogue of associations between exposure patterns, sociodemographic characteristics, and cancer incidence can help inform design of future studies and targeted prevention programmes.
format	article
author	Julia Steinberg Sarsha Yap David Goldsbury Visalini Nair-Shalliker Emily Banks Karen Canfell Dianne L. O’Connell
author_facet	Julia Steinberg Sarsha Yap David Goldsbury Visalini Nair-Shalliker Emily Banks Karen Canfell Dianne L. O’Connell
author_sort	Julia Steinberg
title	Large-scale systematic analysis of exposure to multiple cancer risk factors and the associations between exposure patterns and cancer incidence
title_short	Large-scale systematic analysis of exposure to multiple cancer risk factors and the associations between exposure patterns and cancer incidence
title_full	Large-scale systematic analysis of exposure to multiple cancer risk factors and the associations between exposure patterns and cancer incidence
title_fullStr	Large-scale systematic analysis of exposure to multiple cancer risk factors and the associations between exposure patterns and cancer incidence
title_full_unstemmed	Large-scale systematic analysis of exposure to multiple cancer risk factors and the associations between exposure patterns and cancer incidence
title_sort	large-scale systematic analysis of exposure to multiple cancer risk factors and the associations between exposure patterns and cancer incidence
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/63a95785e4fb45599a21ea253910284c
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Large-scale systematic analysis of exposure to multiple cancer risk factors and the associations between exposure patterns and cancer incidence

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