Effect of dorzolamide/timolol combination on the visual field in glaucoma

Effect of dorzolamide/timolol combination on the visual field in glaucoma

Sakurako Takeda,1,2 Tatsuya Mimura,1 Masao Matsubara1,2 1Department of Ophthalmology, Tokyo Women’s Medical University Medical Center East, Tokyo, Japan; 2Department of Ophthalmology, Nippori Clinic, Medical Center East, Tokyo Women’s Medical University, Tokyo, Japan Purpose:...

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Autores principales: Takeda S, Mimura T, Matsubara M
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Lenguaje:EN
Publicado: Dove Medical Press 2014
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Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/63ac0c431aad4a47951983cd5d376d04
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spelling oai:doaj.org-article:63ac0c431aad4a47951983cd5d376d042021-12-02T05:36:43ZEffect of dorzolamide/timolol combination on the visual field in glaucoma1177-5483https://doaj.org/article/63ac0c431aad4a47951983cd5d376d042014-08-01T00:00:00Zhttp://www.dovepress.com/effect-of-dorzolamidetimolol-combination-onnbspthenbspvisual-field-in--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Sakurako Takeda,1,2 Tatsuya Mimura,1 Masao Matsubara1,2 1Department of Ophthalmology, Tokyo Women’s Medical University Medical Center East, Tokyo, Japan; 2Department of Ophthalmology, Nippori Clinic, Medical Center East, Tokyo Women’s Medical University, Tokyo, Japan Purpose: To evaluate the effect of treatment for 3 years with a dorzolamide/timolol (1%/0.5%) fixed combination (DTFC) on visual field progression in patients with open-angle glaucoma.Participants: A total of 14 consecutive patients were enrolled who had been previously treated with monotherapy or any combination of a beta blocker, carbonic anhydrase inhibitor, and/or prostaglandin analog for primary open-angle glaucoma (POAG; n=4) or normal-tension glaucoma (NTG; n=10).Methods: Patients were switched to DTFC from their prior glaucoma therapy. The IOP was measured at intervals of 4–6 weeks, and the visual fields were examined at least twice a year for 3 years. The annual change of mean deviation (MD slope) was used to quantify visual field loss. Results: The mean MD value was –5.9±5.0 dB at baseline; it was –5.6±4.8 dB at 12 months, –5.9±5.0 dB at 24 months, and –5.6±5.1 dB at 36 months after switching. The mean MD slope was –0.2±0.8 dB/year before switching and 0.3±1.3 dB/year from baseline to 1 year, –0.3±1.1 dB/year from 1–2 years, and 0.3±0.9 dB/year from 2–3 years after switching. The mean MD slope from baseline to 36 months was correlated with the IOP reduction rate at 36 months after switching. Visual field progression was associated with the IOP reduction rate at 12 months after switching.Conclusion: Switching to DTFC from prior glaucoma therapy improved the MD slope for at least 3 years. Reduction of the IOP after switching to DTFC was effective for delaying visual field progression. Although our study was not nonrandomized and was small in scale, the findings suggest that DTFC might have a beneficial effect on the visual fields in patients with open-angle glaucoma. Keywords: dorzolamide/timolol (1%/0.5%) fixed combination, switch, visual field, MD slopeTakeda SMimura TMatsubara MDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 1579-1590 (2014)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Takeda S
Mimura T
Matsubara M
Effect of dorzolamide/timolol combination on the visual field in glaucoma
description Sakurako Takeda,1,2 Tatsuya Mimura,1 Masao Matsubara1,2 1Department of Ophthalmology, Tokyo Women’s Medical University Medical Center East, Tokyo, Japan; 2Department of Ophthalmology, Nippori Clinic, Medical Center East, Tokyo Women’s Medical University, Tokyo, Japan Purpose: To evaluate the effect of treatment for 3 years with a dorzolamide/timolol (1%/0.5%) fixed combination (DTFC) on visual field progression in patients with open-angle glaucoma.Participants: A total of 14 consecutive patients were enrolled who had been previously treated with monotherapy or any combination of a beta blocker, carbonic anhydrase inhibitor, and/or prostaglandin analog for primary open-angle glaucoma (POAG; n=4) or normal-tension glaucoma (NTG; n=10).Methods: Patients were switched to DTFC from their prior glaucoma therapy. The IOP was measured at intervals of 4–6 weeks, and the visual fields were examined at least twice a year for 3 years. The annual change of mean deviation (MD slope) was used to quantify visual field loss. Results: The mean MD value was –5.9±5.0 dB at baseline; it was –5.6±4.8 dB at 12 months, –5.9±5.0 dB at 24 months, and –5.6±5.1 dB at 36 months after switching. The mean MD slope was –0.2±0.8 dB/year before switching and 0.3±1.3 dB/year from baseline to 1 year, –0.3±1.1 dB/year from 1–2 years, and 0.3±0.9 dB/year from 2–3 years after switching. The mean MD slope from baseline to 36 months was correlated with the IOP reduction rate at 36 months after switching. Visual field progression was associated with the IOP reduction rate at 12 months after switching.Conclusion: Switching to DTFC from prior glaucoma therapy improved the MD slope for at least 3 years. Reduction of the IOP after switching to DTFC was effective for delaying visual field progression. Although our study was not nonrandomized and was small in scale, the findings suggest that DTFC might have a beneficial effect on the visual fields in patients with open-angle glaucoma. Keywords: dorzolamide/timolol (1%/0.5%) fixed combination, switch, visual field, MD slope
format article
author Takeda S
Mimura T
Matsubara M
author_facet Takeda S
Mimura T
Matsubara M
author_sort Takeda S
title Effect of dorzolamide/timolol combination on the visual field in glaucoma
title_short Effect of dorzolamide/timolol combination on the visual field in glaucoma
title_full Effect of dorzolamide/timolol combination on the visual field in glaucoma
title_fullStr Effect of dorzolamide/timolol combination on the visual field in glaucoma
title_full_unstemmed Effect of dorzolamide/timolol combination on the visual field in glaucoma
title_sort effect of dorzolamide/timolol combination on the visual field in glaucoma
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/63ac0c431aad4a47951983cd5d376d04
work_keys_str_mv AT takedas effectofdorzolamidetimololcombinationonnbspthenbspvisualfieldinglaucoma
AT mimurat effectofdorzolamidetimololcombinationonnbspthenbspvisualfieldinglaucoma
AT matsubaram effectofdorzolamidetimololcombinationonnbspthenbspvisualfieldinglaucoma
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