The Therapeutic Effects of Oral Intake of Hydrogen Rich Water on Cutaneous Wound Healing in Dogs

This study explored the effects of drinking Hydrogen-rich water (HRW) on skin wound healing in dogs. Eight circular wounds were analyzed in each dog. The experimental group was treated with HRW thrice daily, while the control group was provided with distilled water (DW). The wound tissues of dogs we...

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Autores principales:	Dong-Dong Qi, Meng-Yuan Ding, Ting Wang, Muhammad Abid Hayat, Tao Liu, Jian-Tao Zhang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antioxidant dogs hydrogen-rich water wound healing Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/63adadd05f834f51adf66669cc9fdab9
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spelling	oai:doaj.org-article:63adadd05f834f51adf66669cc9fdab92021-11-25T19:11:59ZThe Therapeutic Effects of Oral Intake of Hydrogen Rich Water on Cutaneous Wound Healing in Dogs10.3390/vetsci81102642306-7381https://doaj.org/article/63adadd05f834f51adf66669cc9fdab92021-11-01T00:00:00Zhttps://www.mdpi.com/2306-7381/8/11/264https://doaj.org/toc/2306-7381This study explored the effects of drinking Hydrogen-rich water (HRW) on skin wound healing in dogs. Eight circular wounds were analyzed in each dog. The experimental group was treated with HRW thrice daily, while the control group was provided with distilled water (DW). The wound tissues of dogs were examined histopathologically. The fibroblasts, inflammatory cell infiltration, the average number of new blood vessels, and the level of malondialdehyde (MDA) and superoxide dismutase (SOD) activity in the skin homogenate of the wound was measured using the corresponding kits. The expressions of Nrf-2, HO-1, NQO-1, VEGF, and PDGF were measured using the real-time fluorescence quantitative method. We observed that HRW wounds showed an increased rate of wound healing, and a faster average healing time compared with DW. Histopathology showed that in the HRW group, the average thickness of the epidermis was significantly lower than the DW group. The average number of blood vessels in the HRW group was higher than the DW group. The MDA levels were higher in the DW group than in the HRW group, but the SOD levels were higher in the HRW group than in the DW group. The results of qRT-PCR showed that the expression of each gene was significantly different between the two groups. HRW treatment promoted skin wound healing in dogs, accelerated wound epithelization, reduced inflammatory reaction, stimulated the expression of cytokines related to wound healing, and shortened wound healing time.Dong-Dong QiMeng-Yuan DingTing WangMuhammad Abid HayatTao LiuJian-Tao ZhangMDPI AGarticleantioxidantdogshydrogen-rich waterwound healingVeterinary medicineSF600-1100ENVeterinary Sciences, Vol 8, Iss 264, p 264 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antioxidant dogs hydrogen-rich water wound healing Veterinary medicine SF600-1100
spellingShingle	antioxidant dogs hydrogen-rich water wound healing Veterinary medicine SF600-1100 Dong-Dong Qi Meng-Yuan Ding Ting Wang Muhammad Abid Hayat Tao Liu Jian-Tao Zhang The Therapeutic Effects of Oral Intake of Hydrogen Rich Water on Cutaneous Wound Healing in Dogs
description	This study explored the effects of drinking Hydrogen-rich water (HRW) on skin wound healing in dogs. Eight circular wounds were analyzed in each dog. The experimental group was treated with HRW thrice daily, while the control group was provided with distilled water (DW). The wound tissues of dogs were examined histopathologically. The fibroblasts, inflammatory cell infiltration, the average number of new blood vessels, and the level of malondialdehyde (MDA) and superoxide dismutase (SOD) activity in the skin homogenate of the wound was measured using the corresponding kits. The expressions of Nrf-2, HO-1, NQO-1, VEGF, and PDGF were measured using the real-time fluorescence quantitative method. We observed that HRW wounds showed an increased rate of wound healing, and a faster average healing time compared with DW. Histopathology showed that in the HRW group, the average thickness of the epidermis was significantly lower than the DW group. The average number of blood vessels in the HRW group was higher than the DW group. The MDA levels were higher in the DW group than in the HRW group, but the SOD levels were higher in the HRW group than in the DW group. The results of qRT-PCR showed that the expression of each gene was significantly different between the two groups. HRW treatment promoted skin wound healing in dogs, accelerated wound epithelization, reduced inflammatory reaction, stimulated the expression of cytokines related to wound healing, and shortened wound healing time.
format	article
author	Dong-Dong Qi Meng-Yuan Ding Ting Wang Muhammad Abid Hayat Tao Liu Jian-Tao Zhang
author_facet	Dong-Dong Qi Meng-Yuan Ding Ting Wang Muhammad Abid Hayat Tao Liu Jian-Tao Zhang
author_sort	Dong-Dong Qi
title	The Therapeutic Effects of Oral Intake of Hydrogen Rich Water on Cutaneous Wound Healing in Dogs
title_short	The Therapeutic Effects of Oral Intake of Hydrogen Rich Water on Cutaneous Wound Healing in Dogs
title_full	The Therapeutic Effects of Oral Intake of Hydrogen Rich Water on Cutaneous Wound Healing in Dogs
title_fullStr	The Therapeutic Effects of Oral Intake of Hydrogen Rich Water on Cutaneous Wound Healing in Dogs
title_full_unstemmed	The Therapeutic Effects of Oral Intake of Hydrogen Rich Water on Cutaneous Wound Healing in Dogs
title_sort	therapeutic effects of oral intake of hydrogen rich water on cutaneous wound healing in dogs
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/63adadd05f834f51adf66669cc9fdab9
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The Therapeutic Effects of Oral Intake of Hydrogen Rich Water on Cutaneous Wound Healing in Dogs

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