Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells

Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells

(1) Background: There is a strong need for prevention and treatment strategies for COVID-19 that are not impacted by SARS-CoV-2 mutations emerging in variants of concern. After virus infection, host ER resident sigma receptors form direct interactions with non-structural SARS-CoV-2 proteins present...

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Auteurs principaux: David A. Ostrov, Andrew P. Bluhm, Danmeng Li, Juveriya Qamar Khan, Megha Rohamare, Karthic Rajamanickam, Kalpana K. Bhanumathy, Jocelyne Lew, Darryl Falzarano, Franco J. Vizeacoumar, Joyce A. Wilson, Marco Mottinelli, Siva Rama Raju Kanumuri, Abhisheak Sharma, Christopher R. McCurdy, Michael H. Norris
Format: article
Langue:EN
Publié: MDPI AG 2021
Sujets:
drug discovery
sigma-1 receptor
SARS-CoV-2
molecular docking
antiviral therapeutics
Medicine
R
Accès en ligne:https://doaj.org/article/63add6fb9ba140d2866daea0ebf129c3
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https://doaj.org/article/63add6fb9ba140d2866daea0ebf129c3

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