Influence of Supercritical Carbon Dioxide Extraction Conditions on Extraction Yield and Composition of Nigella sativa L. Seed Oil—Modelling, Optimization and Extraction Kinetics regarding Fatty Acid and Thymoquinone Content

Nigella sativa L. is cultivated in many regions and its seeds have found use in variety of foods, but also in traditional medicine due to high content of biologically active essential oils. In this work optimization of supercritical carbon dioxide extraction from N. sativ...

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Autores principales:	Grzegorz Gawron, Wojciech Krzyczkowski, Robert Łyżeń, Leszek Kadziński, Bogdan Banecki
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Nigella sativa</i> thymoquinone supercritical fluid extraction response surface methodology antibacterial activity Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/63ae1a43fd9b40fd9893edde7ac08bf7
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spelling	oai:doaj.org-article:63ae1a43fd9b40fd9893edde7ac08bf72021-11-11T18:26:17ZInfluence of Supercritical Carbon Dioxide Extraction Conditions on Extraction Yield and Composition of <i>Nigella sativa</i> L. Seed Oil—Modelling, Optimization and Extraction Kinetics regarding Fatty Acid and Thymoquinone Content10.3390/molecules262164191420-3049https://doaj.org/article/63ae1a43fd9b40fd9893edde7ac08bf72021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6419https://doaj.org/toc/1420-3049<i>Nigella sativa</i> L. is cultivated in many regions and its seeds have found use in variety of foods, but also in traditional medicine due to high content of biologically active essential oils. In this work optimization of supercritical carbon dioxide extraction from <i>N. sativa</i> seeds was performed using response surface methodology to describe the influence of extraction conditions on oil yield. Kinetics of oil and thymoquinone extraction were analyzed as well. It was demonstrated that in order to collect thymoquinone-rich <i>N. sativa</i> oil fraction, appropriate for health-related applications, the extraction should be carried out at 40 °C and 10–15 MPa. Following application of higher pressure of 35 MPa enables effective extraction of remaining oil rich in polyunsaturated fatty acids suitable for use in food industry. Thymoquinone-dependent antibacterial activity of the <i>N. sativa</i> seed oil was observed against bacterial pathogens: <i>Haemophilus influenzae, Staphylococcus haemolyticus, Staphylococcus epidermidis, Enterococcus faecalis</i> and <i>Escherichia coli</i>.Grzegorz GawronWojciech KrzyczkowskiRobert ŁyżeńLeszek KadzińskiBogdan BaneckiMDPI AGarticle<i>Nigella sativa</i>thymoquinonesupercritical fluid extractionresponse surface methodologyantibacterial activityOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6419, p 6419 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Nigella sativa</i> thymoquinone supercritical fluid extraction response surface methodology antibacterial activity Organic chemistry QD241-441
spellingShingle	<i>Nigella sativa</i> thymoquinone supercritical fluid extraction response surface methodology antibacterial activity Organic chemistry QD241-441 Grzegorz Gawron Wojciech Krzyczkowski Robert Łyżeń Leszek Kadziński Bogdan Banecki Influence of Supercritical Carbon Dioxide Extraction Conditions on Extraction Yield and Composition of <i>Nigella sativa</i> L. Seed Oil—Modelling, Optimization and Extraction Kinetics regarding Fatty Acid and Thymoquinone Content
description	<i>Nigella sativa</i> L. is cultivated in many regions and its seeds have found use in variety of foods, but also in traditional medicine due to high content of biologically active essential oils. In this work optimization of supercritical carbon dioxide extraction from <i>N. sativa</i> seeds was performed using response surface methodology to describe the influence of extraction conditions on oil yield. Kinetics of oil and thymoquinone extraction were analyzed as well. It was demonstrated that in order to collect thymoquinone-rich <i>N. sativa</i> oil fraction, appropriate for health-related applications, the extraction should be carried out at 40 °C and 10–15 MPa. Following application of higher pressure of 35 MPa enables effective extraction of remaining oil rich in polyunsaturated fatty acids suitable for use in food industry. Thymoquinone-dependent antibacterial activity of the <i>N. sativa</i> seed oil was observed against bacterial pathogens: <i>Haemophilus influenzae, Staphylococcus haemolyticus, Staphylococcus epidermidis, Enterococcus faecalis</i> and <i>Escherichia coli</i>.
format	article
author	Grzegorz Gawron Wojciech Krzyczkowski Robert Łyżeń Leszek Kadziński Bogdan Banecki
author_facet	Grzegorz Gawron Wojciech Krzyczkowski Robert Łyżeń Leszek Kadziński Bogdan Banecki
author_sort	Grzegorz Gawron
title	Influence of Supercritical Carbon Dioxide Extraction Conditions on Extraction Yield and Composition of <i>Nigella sativa</i> L. Seed Oil—Modelling, Optimization and Extraction Kinetics regarding Fatty Acid and Thymoquinone Content
title_short	Influence of Supercritical Carbon Dioxide Extraction Conditions on Extraction Yield and Composition of <i>Nigella sativa</i> L. Seed Oil—Modelling, Optimization and Extraction Kinetics regarding Fatty Acid and Thymoquinone Content
title_full	Influence of Supercritical Carbon Dioxide Extraction Conditions on Extraction Yield and Composition of <i>Nigella sativa</i> L. Seed Oil—Modelling, Optimization and Extraction Kinetics regarding Fatty Acid and Thymoquinone Content
title_fullStr	Influence of Supercritical Carbon Dioxide Extraction Conditions on Extraction Yield and Composition of <i>Nigella sativa</i> L. Seed Oil—Modelling, Optimization and Extraction Kinetics regarding Fatty Acid and Thymoquinone Content
title_full_unstemmed	Influence of Supercritical Carbon Dioxide Extraction Conditions on Extraction Yield and Composition of <i>Nigella sativa</i> L. Seed Oil—Modelling, Optimization and Extraction Kinetics regarding Fatty Acid and Thymoquinone Content
title_sort	influence of supercritical carbon dioxide extraction conditions on extraction yield and composition of <i>nigella sativa</i> l. seed oil—modelling, optimization and extraction kinetics regarding fatty acid and thymoquinone content
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/63ae1a43fd9b40fd9893edde7ac08bf7
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Influence of Supercritical Carbon Dioxide Extraction Conditions on Extraction Yield and Composition of <i>Nigella sativa</i> L. Seed Oil—Modelling, Optimization and Extraction Kinetics regarding Fatty Acid and Thymoquinone Content

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