Effectiveness of zinc supplementation to full term normal infants: a community based double blind, randomized, controlled, clinical trial.

<h4>Unlabelled</h4>The study was aimed to test whether zinc supplementation, if initiated early, can prevent stunting and promote optimum body composition in full term infants. For this, full term pregnant women from low income urban community were enrolled and were followed-up for 24 mo...

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Autores principales:	K V Radhakrishna, R Hemalatha, J J Babu Geddam, P Ajey Kumar, N Balakrishna, Veena Shatrugna
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/63ae59ca00a04ae79540ad33ae9bb1d0
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spelling	oai:doaj.org-article:63ae59ca00a04ae79540ad33ae9bb1d02021-11-18T07:43:45ZEffectiveness of zinc supplementation to full term normal infants: a community based double blind, randomized, controlled, clinical trial.1932-620310.1371/journal.pone.0061486https://doaj.org/article/63ae59ca00a04ae79540ad33ae9bb1d02013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23737940/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Unlabelled</h4>The study was aimed to test whether zinc supplementation, if initiated early, can prevent stunting and promote optimum body composition in full term infants. For this, full term pregnant women from low income urban community were enrolled and were followed-up for 24 months postpartum. Body mass index (BMI) was calculated from maternal weight and height that were collected one month after delivery. Infants' weight, and length, head, chest and mid upper arm circumferences and skin fold thicknesses at triceps, biceps and subscapular area were collected at baseline (before randomization) and once in three months up till 24 months. Three hundred and twenty four infants were randomized and allocated to zinc (163) or placebo (161) groups respectively. Supplementation of zinc was initiated from 4 months of age and continued till children attained 18 months. The control (placebo) group of children received riboflavin 0.5 mg/day, whereas the intervention (zinc) group received 5 mg zinc plus riboflavin 0.5 mg/day. When infants were 18 months old, dietary intakes (in 78 children) were calculated by 24 hour diet recall method and hemoglobin, zinc, copper and vitamin A were quantified in blood samples collected from 70 children. The results showed prevalence of undernutrition (body mass index <18.5) in 37% of the mothers. Mean±SD calorie consumption and zinc intakes from diets in infants were 590±282.8 Kcal/day and 0.97±0.608 mg/day respectively. Multiple linear regression models demonstrated maternal weight as a strong predictor of infants' weight and length at 18 months of age. As expected, diarrhea duration impacted infants' linear growth and weight gain adversely. Zinc supplementation for a mean period of 190 days, starting from 4 months up to 18 months of age, in full term normal infants, consuming an average energy of 590 Kcal/day, had significant effect on the skin fold thicknesses, but not on their linear growth.<h4>Trial registration</h4>Clinical Trail Registration India (CTRI) CTRI/2012/08/002884.K V RadhakrishnaR HemalathaJ J Babu GeddamP Ajey KumarN BalakrishnaVeena ShatrugnaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e61486 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q K V Radhakrishna R Hemalatha J J Babu Geddam P Ajey Kumar N Balakrishna Veena Shatrugna Effectiveness of zinc supplementation to full term normal infants: a community based double blind, randomized, controlled, clinical trial.
description	<h4>Unlabelled</h4>The study was aimed to test whether zinc supplementation, if initiated early, can prevent stunting and promote optimum body composition in full term infants. For this, full term pregnant women from low income urban community were enrolled and were followed-up for 24 months postpartum. Body mass index (BMI) was calculated from maternal weight and height that were collected one month after delivery. Infants' weight, and length, head, chest and mid upper arm circumferences and skin fold thicknesses at triceps, biceps and subscapular area were collected at baseline (before randomization) and once in three months up till 24 months. Three hundred and twenty four infants were randomized and allocated to zinc (163) or placebo (161) groups respectively. Supplementation of zinc was initiated from 4 months of age and continued till children attained 18 months. The control (placebo) group of children received riboflavin 0.5 mg/day, whereas the intervention (zinc) group received 5 mg zinc plus riboflavin 0.5 mg/day. When infants were 18 months old, dietary intakes (in 78 children) were calculated by 24 hour diet recall method and hemoglobin, zinc, copper and vitamin A were quantified in blood samples collected from 70 children. The results showed prevalence of undernutrition (body mass index <18.5) in 37% of the mothers. Mean±SD calorie consumption and zinc intakes from diets in infants were 590±282.8 Kcal/day and 0.97±0.608 mg/day respectively. Multiple linear regression models demonstrated maternal weight as a strong predictor of infants' weight and length at 18 months of age. As expected, diarrhea duration impacted infants' linear growth and weight gain adversely. Zinc supplementation for a mean period of 190 days, starting from 4 months up to 18 months of age, in full term normal infants, consuming an average energy of 590 Kcal/day, had significant effect on the skin fold thicknesses, but not on their linear growth.<h4>Trial registration</h4>Clinical Trail Registration India (CTRI) CTRI/2012/08/002884.
format	article
author	K V Radhakrishna R Hemalatha J J Babu Geddam P Ajey Kumar N Balakrishna Veena Shatrugna
author_facet	K V Radhakrishna R Hemalatha J J Babu Geddam P Ajey Kumar N Balakrishna Veena Shatrugna
author_sort	K V Radhakrishna
title	Effectiveness of zinc supplementation to full term normal infants: a community based double blind, randomized, controlled, clinical trial.
title_short	Effectiveness of zinc supplementation to full term normal infants: a community based double blind, randomized, controlled, clinical trial.
title_full	Effectiveness of zinc supplementation to full term normal infants: a community based double blind, randomized, controlled, clinical trial.
title_fullStr	Effectiveness of zinc supplementation to full term normal infants: a community based double blind, randomized, controlled, clinical trial.
title_full_unstemmed	Effectiveness of zinc supplementation to full term normal infants: a community based double blind, randomized, controlled, clinical trial.
title_sort	effectiveness of zinc supplementation to full term normal infants: a community based double blind, randomized, controlled, clinical trial.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/63ae59ca00a04ae79540ad33ae9bb1d0
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Effectiveness of zinc supplementation to full term normal infants: a community based double blind, randomized, controlled, clinical trial.

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