Plasma Interleukin-6 Level: A Potential Prognostic Indicator of Emergent HBV-Associated ACLF

Objective. To identify markers that predict the progression to hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF). Methods. We recruited 125 patients with chronic hepatitis B (CHB) between September 2013 and March 2017. During hospitalization, 25 patients progressed to LF and wer...

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Autores principales:	Zhe-Bin Wu, Yu-Bao Zheng, Ke Wang, Zhi-Shuo Mo, Xu Zhen, Ying Yan, Zhi-Liang Gao
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/63aee7813af74e518eb2bd218aa1c15c
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spelling	oai:doaj.org-article:63aee7813af74e518eb2bd218aa1c15c2021-11-22T01:11:25ZPlasma Interleukin-6 Level: A Potential Prognostic Indicator of Emergent HBV-Associated ACLF2291-279710.1155/2021/5545181https://doaj.org/article/63aee7813af74e518eb2bd218aa1c15c2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5545181https://doaj.org/toc/2291-2797Objective. To identify markers that predict the progression to hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF). Methods. We recruited 125 patients with chronic hepatitis B (CHB) between September 2013 and March 2017. During hospitalization, 25 patients progressed to LF and were classified as the LF group, while the remaining 100 patients were classified as the non-LF (NLF) group. We compared the kinetic changes in clinical and immune indicators including age, total bilirubin level, prothrombin time, model for end-stage liver disease score, interleukin (IL)-6, IL-8, and IL-10 cytokine levels, and number of T helper 17 and regulatory T cells between groups to determine their association with progression to HBV-ACLF. The prognostic value of clinical and immune indicators was determined using the area under the receiver operating characteristic curve (AUC) value. Results. Cox regression analysis suggested that the plasma IL-6 level could predict CHB progression to HBV-ACLF (relative risk = 1.082, 95% confidence interval: 1.006–1.164; P=0.034). The AUC value, sensitivity, and specificity of baseline IL-6 level for predicting HBV-ACLF were 82.63%, 83.3%, and 82.9%, respectively (P=0.001). Conclusion. A high plasma IL-6 level in CHB patients could be an early biomarker for HBV-ACLF.Zhe-Bin WuYu-Bao ZhengKe WangZhi-Shuo MoXu ZhenYing YanZhi-Liang GaoHindawi LimitedarticleDiseases of the digestive system. GastroenterologyRC799-869ENCanadian Journal of Gastroenterology and Hepatology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 Zhe-Bin Wu Yu-Bao Zheng Ke Wang Zhi-Shuo Mo Xu Zhen Ying Yan Zhi-Liang Gao Plasma Interleukin-6 Level: A Potential Prognostic Indicator of Emergent HBV-Associated ACLF
description	Objective. To identify markers that predict the progression to hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF). Methods. We recruited 125 patients with chronic hepatitis B (CHB) between September 2013 and March 2017. During hospitalization, 25 patients progressed to LF and were classified as the LF group, while the remaining 100 patients were classified as the non-LF (NLF) group. We compared the kinetic changes in clinical and immune indicators including age, total bilirubin level, prothrombin time, model for end-stage liver disease score, interleukin (IL)-6, IL-8, and IL-10 cytokine levels, and number of T helper 17 and regulatory T cells between groups to determine their association with progression to HBV-ACLF. The prognostic value of clinical and immune indicators was determined using the area under the receiver operating characteristic curve (AUC) value. Results. Cox regression analysis suggested that the plasma IL-6 level could predict CHB progression to HBV-ACLF (relative risk = 1.082, 95% confidence interval: 1.006–1.164; P=0.034). The AUC value, sensitivity, and specificity of baseline IL-6 level for predicting HBV-ACLF were 82.63%, 83.3%, and 82.9%, respectively (P=0.001). Conclusion. A high plasma IL-6 level in CHB patients could be an early biomarker for HBV-ACLF.
format	article
author	Zhe-Bin Wu Yu-Bao Zheng Ke Wang Zhi-Shuo Mo Xu Zhen Ying Yan Zhi-Liang Gao
author_facet	Zhe-Bin Wu Yu-Bao Zheng Ke Wang Zhi-Shuo Mo Xu Zhen Ying Yan Zhi-Liang Gao
author_sort	Zhe-Bin Wu
title	Plasma Interleukin-6 Level: A Potential Prognostic Indicator of Emergent HBV-Associated ACLF
title_short	Plasma Interleukin-6 Level: A Potential Prognostic Indicator of Emergent HBV-Associated ACLF
title_full	Plasma Interleukin-6 Level: A Potential Prognostic Indicator of Emergent HBV-Associated ACLF
title_fullStr	Plasma Interleukin-6 Level: A Potential Prognostic Indicator of Emergent HBV-Associated ACLF
title_full_unstemmed	Plasma Interleukin-6 Level: A Potential Prognostic Indicator of Emergent HBV-Associated ACLF
title_sort	plasma interleukin-6 level: a potential prognostic indicator of emergent hbv-associated aclf
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/63aee7813af74e518eb2bd218aa1c15c
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Plasma Interleukin-6 Level: A Potential Prognostic Indicator of Emergent HBV-Associated ACLF

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