Electroacupuncture Upregulates HIF-1α and SOX9 Expression in Knee Osteoarthritis

Electroacupuncture (EA) has been clinically used in knee osteoarthritis broadly and proved to be effective than other therapies with fewer side effects; however, the mechanism of electroacupuncture to work on cartilage remains unclear. In this study, we aimed to evaluate the effect of EA treatment o...

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Autores principales:	Jie Tong, Chengyuan Deng, Guanghua Sun, Jun Zhou, Peirui Zhong, Tiantian Wang, Ye Zeng, Qi Wu, Yuan Liao, Fu Luo, Ting Peng, Ying Liao
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/63af580c43b14cd08bcac1756c8c66a0
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id	oai:doaj.org-article:63af580c43b14cd08bcac1756c8c66a0
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spelling	oai:doaj.org-article:63af580c43b14cd08bcac1756c8c66a02021-11-15T01:20:10ZElectroacupuncture Upregulates HIF-1α and SOX9 Expression in Knee Osteoarthritis1741-428810.1155/2021/2047097https://doaj.org/article/63af580c43b14cd08bcac1756c8c66a02021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/2047097https://doaj.org/toc/1741-4288Electroacupuncture (EA) has been clinically used in knee osteoarthritis broadly and proved to be effective than other therapies with fewer side effects; however, the mechanism of electroacupuncture to work on cartilage remains unclear. In this study, we aimed to evaluate the effect of EA treatment on cartilage and the relationship between EA and proteins such as HIF-a and SOX9. EA (dilatational wave, 3–15 HZ, 1 mA) has been applied to bilateral Zusanli (ST36), Xuehai (SP10), Taixi (KI3), and Yanglingquan (GB34) of rats. Results showed that the cartilage of the knee osteoarthritis group had obvious damage and fissure formation while the EA group showed that the cartilage destruction was generally milder. In addition, the protein expression levels of HIF-1α, and chondrogenic markers such as Sox9, and ACAN in the electroacupuncture group were higher than those in the ACLT group. Also, the extracellular matrix protein expression levels of MMP13 and ADAMTS5 were decreased in the EA group. These findings indicate that EA could alleviate the severity of knee osteoarthritis, and HIF-a and SOX9 may closely attribute to the treatment.Jie TongChengyuan DengGuanghua SunJun ZhouPeirui ZhongTiantian WangYe ZengQi WuYuan LiaoFu LuoTing PengYing LiaoHindawi LimitedarticleOther systems of medicineRZ201-999ENEvidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Other systems of medicine RZ201-999
spellingShingle	Other systems of medicine RZ201-999 Jie Tong Chengyuan Deng Guanghua Sun Jun Zhou Peirui Zhong Tiantian Wang Ye Zeng Qi Wu Yuan Liao Fu Luo Ting Peng Ying Liao Electroacupuncture Upregulates HIF-1α and SOX9 Expression in Knee Osteoarthritis
description	Electroacupuncture (EA) has been clinically used in knee osteoarthritis broadly and proved to be effective than other therapies with fewer side effects; however, the mechanism of electroacupuncture to work on cartilage remains unclear. In this study, we aimed to evaluate the effect of EA treatment on cartilage and the relationship between EA and proteins such as HIF-a and SOX9. EA (dilatational wave, 3–15 HZ, 1 mA) has been applied to bilateral Zusanli (ST36), Xuehai (SP10), Taixi (KI3), and Yanglingquan (GB34) of rats. Results showed that the cartilage of the knee osteoarthritis group had obvious damage and fissure formation while the EA group showed that the cartilage destruction was generally milder. In addition, the protein expression levels of HIF-1α, and chondrogenic markers such as Sox9, and ACAN in the electroacupuncture group were higher than those in the ACLT group. Also, the extracellular matrix protein expression levels of MMP13 and ADAMTS5 were decreased in the EA group. These findings indicate that EA could alleviate the severity of knee osteoarthritis, and HIF-a and SOX9 may closely attribute to the treatment.
format	article
author	Jie Tong Chengyuan Deng Guanghua Sun Jun Zhou Peirui Zhong Tiantian Wang Ye Zeng Qi Wu Yuan Liao Fu Luo Ting Peng Ying Liao
author_facet	Jie Tong Chengyuan Deng Guanghua Sun Jun Zhou Peirui Zhong Tiantian Wang Ye Zeng Qi Wu Yuan Liao Fu Luo Ting Peng Ying Liao
author_sort	Jie Tong
title	Electroacupuncture Upregulates HIF-1α and SOX9 Expression in Knee Osteoarthritis
title_short	Electroacupuncture Upregulates HIF-1α and SOX9 Expression in Knee Osteoarthritis
title_full	Electroacupuncture Upregulates HIF-1α and SOX9 Expression in Knee Osteoarthritis
title_fullStr	Electroacupuncture Upregulates HIF-1α and SOX9 Expression in Knee Osteoarthritis
title_full_unstemmed	Electroacupuncture Upregulates HIF-1α and SOX9 Expression in Knee Osteoarthritis
title_sort	electroacupuncture upregulates hif-1α and sox9 expression in knee osteoarthritis
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/63af580c43b14cd08bcac1756c8c66a0
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Electroacupuncture Upregulates HIF-1α and SOX9 Expression in Knee Osteoarthritis

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