Novel Small Molecule Inhibitors That Prevent the Neuroparalysis of Tetanus Neurotoxin

Tetanus neurotoxin (TeNT) is a protein exotoxin produced by <i>Clostridium tetani</i> that causes the deadly spastic neuroparalysis of tetanus. It consists of a metalloprotease light chain and of a heavy chain linked via a disulphide bond. TeNT binds to the neuromuscular junction (NMJ) a...

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Autores principales: Giulia Zanetti, Andrea Mattarei, Florigio Lista, Ornella Rossetto, Cesare Montecucco, Marco Pirazzini
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/63b35b43dab140a88f7cfa13188faf6a
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