Effects of open-label placebos on test performance and psychological well-being in healthy medical students: a randomized controlled trial

Abstract Psychological distress is prevalent in students and can predispose to psychiatric disorders. Recent findings indicate that distress might be linked to impaired cognitive performance in students. Experimental findings in healthy participants suggest that placebo interventions can improve cog...

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Autores principales:	Julian Kleine-Borgmann, Katharina Schmidt, Marieke Billinger, Katarina Forkmann, Katja Wiech, Ulrike Bingel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/63b6868cbc544c888b6f35fd5f5a139d
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spelling	oai:doaj.org-article:63b6868cbc544c888b6f35fd5f5a139d2021-12-02T10:49:16ZEffects of open-label placebos on test performance and psychological well-being in healthy medical students: a randomized controlled trial10.1038/s41598-021-81502-22045-2322https://doaj.org/article/63b6868cbc544c888b6f35fd5f5a139d2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81502-2https://doaj.org/toc/2045-2322Abstract Psychological distress is prevalent in students and can predispose to psychiatric disorders. Recent findings indicate that distress might be linked to impaired cognitive performance in students. Experimental findings in healthy participants suggest that placebo interventions can improve cognition. However, whether non-deceptive (i.e., open-label, OLP) placebos can enhance cognitive function and emotional well-being is unclear. Using a randomized-controlled design we demonstrate a positive impact of OLP on subjective well-being (i.e., stress, fatigue, and confusion) after a 21-day OLP application in healthy students during midterm exams. OLP did not improve test performance, but, within the OLP group, test performance was positively correlated with measures of general belief in the benefit of medication. These results show that OLP can counteract negative effects of acute stress on psychological well-being and might improve cognitive performance if supported by positive treatment expectations. Additionally, our findings in healthy volunteers warrant further investigation in exploring the potential of OLP in reducing stress-related psychological effects in patients. The trial was preregistered at the German Clinical Trials Register on December 20, 2017 (DRKS00013557).Julian Kleine-BorgmannKatharina SchmidtMarieke BillingerKatarina ForkmannKatja WiechUlrike BingelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julian Kleine-Borgmann Katharina Schmidt Marieke Billinger Katarina Forkmann Katja Wiech Ulrike Bingel Effects of open-label placebos on test performance and psychological well-being in healthy medical students: a randomized controlled trial
description	Abstract Psychological distress is prevalent in students and can predispose to psychiatric disorders. Recent findings indicate that distress might be linked to impaired cognitive performance in students. Experimental findings in healthy participants suggest that placebo interventions can improve cognition. However, whether non-deceptive (i.e., open-label, OLP) placebos can enhance cognitive function and emotional well-being is unclear. Using a randomized-controlled design we demonstrate a positive impact of OLP on subjective well-being (i.e., stress, fatigue, and confusion) after a 21-day OLP application in healthy students during midterm exams. OLP did not improve test performance, but, within the OLP group, test performance was positively correlated with measures of general belief in the benefit of medication. These results show that OLP can counteract negative effects of acute stress on psychological well-being and might improve cognitive performance if supported by positive treatment expectations. Additionally, our findings in healthy volunteers warrant further investigation in exploring the potential of OLP in reducing stress-related psychological effects in patients. The trial was preregistered at the German Clinical Trials Register on December 20, 2017 (DRKS00013557).
format	article
author	Julian Kleine-Borgmann Katharina Schmidt Marieke Billinger Katarina Forkmann Katja Wiech Ulrike Bingel
author_facet	Julian Kleine-Borgmann Katharina Schmidt Marieke Billinger Katarina Forkmann Katja Wiech Ulrike Bingel
author_sort	Julian Kleine-Borgmann
title	Effects of open-label placebos on test performance and psychological well-being in healthy medical students: a randomized controlled trial
title_short	Effects of open-label placebos on test performance and psychological well-being in healthy medical students: a randomized controlled trial
title_full	Effects of open-label placebos on test performance and psychological well-being in healthy medical students: a randomized controlled trial
title_fullStr	Effects of open-label placebos on test performance and psychological well-being in healthy medical students: a randomized controlled trial
title_full_unstemmed	Effects of open-label placebos on test performance and psychological well-being in healthy medical students: a randomized controlled trial
title_sort	effects of open-label placebos on test performance and psychological well-being in healthy medical students: a randomized controlled trial
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/63b6868cbc544c888b6f35fd5f5a139d
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Effects of open-label placebos on test performance and psychological well-being in healthy medical students: a randomized controlled trial

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