EFFECTS OF STEROID HORMONES UPON TH1/TH2 CYTOKINE PRODUCTION BY CD45RO+ T CELLS
Abstract. The aim of our study was to evaluate effects of steroid hormones upon the imbalance of Th1/Th2 cytokine production (IL-2, IFNγ, IL-4, IL-10) by CD45RO+ activated lymphocytes. In our experiments, we have shown a clear trend of multidirectional influence of steroid hormones upon secretory ac...
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2014
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oai:doaj.org-article:63be152c85c24655a72ec13ee1b0d0762021-11-18T08:03:43ZEFFECTS OF STEROID HORMONES UPON TH1/TH2 CYTOKINE PRODUCTION BY CD45RO+ T CELLS1563-06252313-741X10.15789/1563-0625-2013-3-263-268https://doaj.org/article/63be152c85c24655a72ec13ee1b0d0762014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/607https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The aim of our study was to evaluate effects of steroid hormones upon the imbalance of Th1/Th2 cytokine production (IL-2, IFNγ, IL-4, IL-10) by CD45RO+ activated lymphocytes. In our experiments, we have shown a clear trend of multidirectional influence of steroid hormones upon secretory activity of T-lymphocytes. We have revealed that development of cellular immune responses mediated by type 1 T helper cells is regulated primarily by female sex hormones. Glucocorticoid hormones seem to exert a marked effect upon development of humoral Th2 immune response. For androgens, some controversial results have been obtained.A. A. GutsolL. S. LitvinovaSPb RAACIarticlememory t cellssteroid hormonescytokinesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 3, Pp 263-268 (2014) |
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DOAJ |
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DOAJ |
| language |
RU |
| topic |
memory t cells steroid hormones cytokines Immunologic diseases. Allergy RC581-607 |
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memory t cells steroid hormones cytokines Immunologic diseases. Allergy RC581-607 A. A. Gutsol L. S. Litvinova EFFECTS OF STEROID HORMONES UPON TH1/TH2 CYTOKINE PRODUCTION BY CD45RO+ T CELLS |
| description |
Abstract. The aim of our study was to evaluate effects of steroid hormones upon the imbalance of Th1/Th2 cytokine production (IL-2, IFNγ, IL-4, IL-10) by CD45RO+ activated lymphocytes. In our experiments, we have shown a clear trend of multidirectional influence of steroid hormones upon secretory activity of T-lymphocytes. We have revealed that development of cellular immune responses mediated by type 1 T helper cells is regulated primarily by female sex hormones. Glucocorticoid hormones seem to exert a marked effect upon development of humoral Th2 immune response. For androgens, some controversial results have been obtained. |
| format |
article |
| author |
A. A. Gutsol L. S. Litvinova |
| author_facet |
A. A. Gutsol L. S. Litvinova |
| author_sort |
A. A. Gutsol |
| title |
EFFECTS OF STEROID HORMONES UPON TH1/TH2 CYTOKINE PRODUCTION BY CD45RO+ T CELLS |
| title_short |
EFFECTS OF STEROID HORMONES UPON TH1/TH2 CYTOKINE PRODUCTION BY CD45RO+ T CELLS |
| title_full |
EFFECTS OF STEROID HORMONES UPON TH1/TH2 CYTOKINE PRODUCTION BY CD45RO+ T CELLS |
| title_fullStr |
EFFECTS OF STEROID HORMONES UPON TH1/TH2 CYTOKINE PRODUCTION BY CD45RO+ T CELLS |
| title_full_unstemmed |
EFFECTS OF STEROID HORMONES UPON TH1/TH2 CYTOKINE PRODUCTION BY CD45RO+ T CELLS |
| title_sort |
effects of steroid hormones upon th1/th2 cytokine production by cd45ro+ t cells |
| publisher |
SPb RAACI |
| publishDate |
2014 |
| url |
https://doaj.org/article/63be152c85c24655a72ec13ee1b0d076 |
| work_keys_str_mv |
AT aagutsol effectsofsteroidhormonesuponth1th2cytokineproductionbycd45rotcells AT lslitvinova effectsofsteroidhormonesuponth1th2cytokineproductionbycd45rotcells |
| _version_ |
1718422421629829120 |