Drosophila STING protein has a role in lipid metabolism

Stimulator of interferon genes (STING) plays an important role in innate immunity by controlling type I interferon response against invaded pathogens. In this work, we describe a previously unknown role of STING in lipid metabolism in Drosophila. Flies with STING deletion are sensitive to starvation...

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Autores principales:	Katarina Akhmetova, Maxim Balasov, Igor Chesnokov
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	Drosophila STING lipid metabolism Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/63bf9e4a64c542be86771e4429ec5e94
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spelling	oai:doaj.org-article:63bf9e4a64c542be86771e4429ec5e942021-11-15T07:20:20ZDrosophila STING protein has a role in lipid metabolism10.7554/eLife.673582050-084Xe67358https://doaj.org/article/63bf9e4a64c542be86771e4429ec5e942021-09-01T00:00:00Zhttps://elifesciences.org/articles/67358https://doaj.org/toc/2050-084XStimulator of interferon genes (STING) plays an important role in innate immunity by controlling type I interferon response against invaded pathogens. In this work, we describe a previously unknown role of STING in lipid metabolism in Drosophila. Flies with STING deletion are sensitive to starvation and oxidative stress, have reduced lipid storage, and downregulated expression of lipid metabolism genes. We found that Drosophila STING interacts with lipid synthesizing enzymes acetyl-CoA carboxylase (ACC) and fatty acid synthase (FASN). ACC and FASN also interact with each other, indicating that all three proteins may be components of a large multi-enzyme complex. The deletion of Drosophila STING leads to disturbed ACC localization and decreased FASN enzyme activity. Together, our results demonstrate a previously undescribed role of STING in lipid metabolism in Drosophila.Katarina AkhmetovaMaxim BalasovIgor ChesnokoveLife Sciences Publications LtdarticleDrosophilaSTINGlipid metabolismMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Drosophila STING lipid metabolism Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	Drosophila STING lipid metabolism Medicine R Science Q Biology (General) QH301-705.5 Katarina Akhmetova Maxim Balasov Igor Chesnokov Drosophila STING protein has a role in lipid metabolism
description	Stimulator of interferon genes (STING) plays an important role in innate immunity by controlling type I interferon response against invaded pathogens. In this work, we describe a previously unknown role of STING in lipid metabolism in Drosophila. Flies with STING deletion are sensitive to starvation and oxidative stress, have reduced lipid storage, and downregulated expression of lipid metabolism genes. We found that Drosophila STING interacts with lipid synthesizing enzymes acetyl-CoA carboxylase (ACC) and fatty acid synthase (FASN). ACC and FASN also interact with each other, indicating that all three proteins may be components of a large multi-enzyme complex. The deletion of Drosophila STING leads to disturbed ACC localization and decreased FASN enzyme activity. Together, our results demonstrate a previously undescribed role of STING in lipid metabolism in Drosophila.
format	article
author	Katarina Akhmetova Maxim Balasov Igor Chesnokov
author_facet	Katarina Akhmetova Maxim Balasov Igor Chesnokov
author_sort	Katarina Akhmetova
title	Drosophila STING protein has a role in lipid metabolism
title_short	Drosophila STING protein has a role in lipid metabolism
title_full	Drosophila STING protein has a role in lipid metabolism
title_fullStr	Drosophila STING protein has a role in lipid metabolism
title_full_unstemmed	Drosophila STING protein has a role in lipid metabolism
title_sort	drosophila sting protein has a role in lipid metabolism
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/63bf9e4a64c542be86771e4429ec5e94
work_keys_str_mv	AT katarinaakhmetova drosophilastingproteinhasaroleinlipidmetabolism AT maximbalasov drosophilastingproteinhasaroleinlipidmetabolism AT igorchesnokov drosophilastingproteinhasaroleinlipidmetabolism
_version_	1718428501197979648

Drosophila STING protein has a role in lipid metabolism

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