Effect of melanin on gold nanoparticle-induced hepatotoxicity and lipid peroxidation in rats

Mohamed Anwar K Abdelhalim,1 Sherif A Abdelmottaleb Moussa,2,3 Huda AY Qaid,1 Mohammed Suliman Al-Ayed1 1Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Committee of Radiation and Environmental Pollution Protection (CREPP), Department of Physics...

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Autores principales:	Abdelhalim MAK, Moussa SAA, Qaid HAY, Al-Ayed MS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	liver gold nanoparticles hepatotoxicity oxidative stress lipid peroxidation histological investigation Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/63c2c7b5c08d4ecd8fc6ba9281407123
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spelling	oai:doaj.org-article:63c2c7b5c08d4ecd8fc6ba92814071232021-12-02T09:28:02ZEffect of melanin on gold nanoparticle-induced hepatotoxicity and lipid peroxidation in rats1178-2013https://doaj.org/article/63c2c7b5c08d4ecd8fc6ba92814071232018-09-01T00:00:00Zhttps://www.dovepress.com/effect-of-melanin-on-gold-nanoparticle-induced-hepatotoxicity-and-lipi-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Mohamed Anwar K Abdelhalim,1 Sherif A Abdelmottaleb Moussa,2,3 Huda AY Qaid,1 Mohammed Suliman Al-Ayed1 1Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Committee of Radiation and Environmental Pollution Protection (CREPP), Department of Physics, College of Science, Al-Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia; 3Biophysics Group, Biochemistry Department, Genetic Engineering and Biotechnology Division, National Research Center, Giza, Egypt Introduction: Melanin pigments are produced by melanocytes and are believed to act as antioxidants based on the belief that melanin can suppress electronically stirred states and scavenge the free radicals. Materials and methods: The study was aimed to verify and prove the toxicity induced by administration of gold nanoparticles (GNPs) and to characterize the role of melanin as an antioxidant against inflammatory liver damage, oxidative stress, and lipid peroxidation induced intraperitoneally by GNPs in vivo. Results: The findings from this study confirmed that administration of GNPs intraperitoneally caused liver damage in addition to producing oxidative stress and fatty acid peroxidation. The treatment of rats with melanin along with GNPs induced dramatic changes in all the measured biochemical parameters. Our data demonstrated that melanin completely inhibited inflammatory liver damage, oxidative stress, and lipid peroxidation, which was confirmed by the histological investigation of different liver sections stained by H&E. Conclusion: These results suggest the beneficial use of melanin together with GNPs for alleviating its toxicity. Other studies should be implemented taking into consideration the role of melanin in comparison with other natural antioxidants. Keywords: liver, gold nanoparticles, hepatotoxicity, oxidative stress, lipid peroxidation, histological investigationAbdelhalim MAKMoussa SAAQaid HAYAl-Ayed MSDove Medical Pressarticlelivergold nanoparticleshepatotoxicityoxidative stresslipid peroxidationhistological investigationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 5207-5213 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	liver gold nanoparticles hepatotoxicity oxidative stress lipid peroxidation histological investigation Medicine (General) R5-920
spellingShingle	liver gold nanoparticles hepatotoxicity oxidative stress lipid peroxidation histological investigation Medicine (General) R5-920 Abdelhalim MAK Moussa SAA Qaid HAY Al-Ayed MS Effect of melanin on gold nanoparticle-induced hepatotoxicity and lipid peroxidation in rats
description	Mohamed Anwar K Abdelhalim,1 Sherif A Abdelmottaleb Moussa,2,3 Huda AY Qaid,1 Mohammed Suliman Al-Ayed1 1Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Committee of Radiation and Environmental Pollution Protection (CREPP), Department of Physics, College of Science, Al-Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia; 3Biophysics Group, Biochemistry Department, Genetic Engineering and Biotechnology Division, National Research Center, Giza, Egypt Introduction: Melanin pigments are produced by melanocytes and are believed to act as antioxidants based on the belief that melanin can suppress electronically stirred states and scavenge the free radicals. Materials and methods: The study was aimed to verify and prove the toxicity induced by administration of gold nanoparticles (GNPs) and to characterize the role of melanin as an antioxidant against inflammatory liver damage, oxidative stress, and lipid peroxidation induced intraperitoneally by GNPs in vivo. Results: The findings from this study confirmed that administration of GNPs intraperitoneally caused liver damage in addition to producing oxidative stress and fatty acid peroxidation. The treatment of rats with melanin along with GNPs induced dramatic changes in all the measured biochemical parameters. Our data demonstrated that melanin completely inhibited inflammatory liver damage, oxidative stress, and lipid peroxidation, which was confirmed by the histological investigation of different liver sections stained by H&E. Conclusion: These results suggest the beneficial use of melanin together with GNPs for alleviating its toxicity. Other studies should be implemented taking into consideration the role of melanin in comparison with other natural antioxidants. Keywords: liver, gold nanoparticles, hepatotoxicity, oxidative stress, lipid peroxidation, histological investigation
format	article
author	Abdelhalim MAK Moussa SAA Qaid HAY Al-Ayed MS
author_facet	Abdelhalim MAK Moussa SAA Qaid HAY Al-Ayed MS
author_sort	Abdelhalim MAK
title	Effect of melanin on gold nanoparticle-induced hepatotoxicity and lipid peroxidation in rats
title_short	Effect of melanin on gold nanoparticle-induced hepatotoxicity and lipid peroxidation in rats
title_full	Effect of melanin on gold nanoparticle-induced hepatotoxicity and lipid peroxidation in rats
title_fullStr	Effect of melanin on gold nanoparticle-induced hepatotoxicity and lipid peroxidation in rats
title_full_unstemmed	Effect of melanin on gold nanoparticle-induced hepatotoxicity and lipid peroxidation in rats
title_sort	effect of melanin on gold nanoparticle-induced hepatotoxicity and lipid peroxidation in rats
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/63c2c7b5c08d4ecd8fc6ba9281407123
work_keys_str_mv	AT abdelhalimmak effectofmelaninongoldnanoparticleinducedhepatotoxicityandlipidperoxidationinrats AT moussasaa effectofmelaninongoldnanoparticleinducedhepatotoxicityandlipidperoxidationinrats AT qaidhay effectofmelaninongoldnanoparticleinducedhepatotoxicityandlipidperoxidationinrats AT alayedms effectofmelaninongoldnanoparticleinducedhepatotoxicityandlipidperoxidationinrats
_version_	1718398124574113792

Effect of melanin on gold nanoparticle-induced hepatotoxicity and lipid peroxidation in rats

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