Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4DCAF5 ubiquitin ligase

Lysine methylation is increasingly being implicated in the modification of non-histone proteins. Here the authors find that the methylation of DNMT1 and E2F1 are recognized by the protein L3MBTL3 and the ubiquitin E3 ligase CRL4D C A F5, which cooperatively target these methylated proteins for ubiqu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Feng Leng, Jiekai Yu, Chunxiao Zhang, Salvador Alejo, Nam Hoang, Hong Sun, Fei Lu, Hui Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/63c469553fe840f491a9d738d641a399
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:63c469553fe840f491a9d738d641a399
record_format	dspace
spelling	oai:doaj.org-article:63c469553fe840f491a9d738d641a3992021-12-02T17:33:15ZMethylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4DCAF5 ubiquitin ligase10.1038/s41467-018-04019-92041-1723https://doaj.org/article/63c469553fe840f491a9d738d641a3992018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04019-9https://doaj.org/toc/2041-1723Lysine methylation is increasingly being implicated in the modification of non-histone proteins. Here the authors find that the methylation of DNMT1 and E2F1 are recognized by the protein L3MBTL3 and the ubiquitin E3 ligase CRL4D C A F5, which cooperatively target these methylated proteins for ubiquitin-dependent proteolysis.Feng LengJiekai YuChunxiao ZhangSalvador AlejoNam HoangHong SunFei LuHui ZhangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Feng Leng Jiekai Yu Chunxiao Zhang Salvador Alejo Nam Hoang Hong Sun Fei Lu Hui Zhang Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4DCAF5 ubiquitin ligase
description	Lysine methylation is increasingly being implicated in the modification of non-histone proteins. Here the authors find that the methylation of DNMT1 and E2F1 are recognized by the protein L3MBTL3 and the ubiquitin E3 ligase CRL4D C A F5, which cooperatively target these methylated proteins for ubiquitin-dependent proteolysis.
format	article
author	Feng Leng Jiekai Yu Chunxiao Zhang Salvador Alejo Nam Hoang Hong Sun Fei Lu Hui Zhang
author_facet	Feng Leng Jiekai Yu Chunxiao Zhang Salvador Alejo Nam Hoang Hong Sun Fei Lu Hui Zhang
author_sort	Feng Leng
title	Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4DCAF5 ubiquitin ligase
title_short	Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4DCAF5 ubiquitin ligase
title_full	Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4DCAF5 ubiquitin ligase
title_fullStr	Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4DCAF5 ubiquitin ligase
title_full_unstemmed	Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4DCAF5 ubiquitin ligase
title_sort	methylated dnmt1 and e2f1 are targeted for proteolysis by l3mbtl3 and crl4dcaf5 ubiquitin ligase
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/63c469553fe840f491a9d738d641a399
work_keys_str_mv	AT fengleng methylateddnmt1ande2f1aretargetedforproteolysisbyl3mbtl3andcrl4dcaf5ubiquitinligase AT jiekaiyu methylateddnmt1ande2f1aretargetedforproteolysisbyl3mbtl3andcrl4dcaf5ubiquitinligase AT chunxiaozhang methylateddnmt1ande2f1aretargetedforproteolysisbyl3mbtl3andcrl4dcaf5ubiquitinligase AT salvadoralejo methylateddnmt1ande2f1aretargetedforproteolysisbyl3mbtl3andcrl4dcaf5ubiquitinligase AT namhoang methylateddnmt1ande2f1aretargetedforproteolysisbyl3mbtl3andcrl4dcaf5ubiquitinligase AT hongsun methylateddnmt1ande2f1aretargetedforproteolysisbyl3mbtl3andcrl4dcaf5ubiquitinligase AT feilu methylateddnmt1ande2f1aretargetedforproteolysisbyl3mbtl3andcrl4dcaf5ubiquitinligase AT huizhang methylateddnmt1ande2f1aretargetedforproteolysisbyl3mbtl3andcrl4dcaf5ubiquitinligase
_version_	1718380003283959808

Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4DCAF5 ubiquitin ligase

Ejemplares similares