The Combination of Serum BDNF, Cortisol and IFN-Gamma Can Assist the Diagnosis of Major Depressive Disorder

Suzhen Chen,1,2 Yuqun Zhang,3 Yonggui Yuan1,2 1Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, 210009, People’s Republic of China; 2Institute of Psychosomatics, School of Medicine, Southeast University, Nanjing, 210009, People’s Repub...

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Autores principales:	Chen S, Zhang Y, Yuan Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	major depressive disorder inflammation factors cortisol neurotrophic factors objective diagnostic platform efficacy predictor Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/63c4edb37a584c91b57bd8633a81d5cf
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spelling	oai:doaj.org-article:63c4edb37a584c91b57bd8633a81d5cf2021-12-02T18:56:49ZThe Combination of Serum BDNF, Cortisol and IFN-Gamma Can Assist the Diagnosis of Major Depressive Disorder1178-2021https://doaj.org/article/63c4edb37a584c91b57bd8633a81d5cf2021-08-01T00:00:00Zhttps://www.dovepress.com/the-combination-of-serum-bdnf-cortisol-and-ifn-gamma-can-assist-the-di-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Suzhen Chen,1,2 Yuqun Zhang,3 Yonggui Yuan1,2 1Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, 210009, People’s Republic of China; 2Institute of Psychosomatics, School of Medicine, Southeast University, Nanjing, 210009, People’s Republic of China; 3School of Nursing, Nanjing University of Chinese Medicine, Nanjing, 210023, People’s Republic of ChinaCorrespondence: Yonggui YuanDepartment of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, No. 87 Dingjiaqiao, Gulou District, Nanjing, 210009, People’s Republic of ChinaTel +86 25- 83285124Email yygylh2000@sina.comPurpose: Misdiagnosis and ineffective treatment are common in major depressive disorder (MDD) in current clinical practice, while the combination of various serum proteins may assist the correct diagnosis. The study aimed to explore whether the combination of serum inflammatory, stress, and neurotrophic factors could be helpful for the diagnosis of MDD and to investigate the predictors associated with early symptom improvements.Patients and Methods: Baseline serum levels of C-reactive protein (CRP), interleukin (IL)-6, IL-10, IL-1beta, tumor necrosis factor (TNF)-alpha, interferon (INF)-gamma, cortisol, and brain-derived neurotrophic factor (BDNF) were detected in 30 MDD patients and 30 age- and gender-matched healthy controls. 17-item Hamilton Depression Rating Scale (HAMD-17) and Hamilton Anxiety Rating Scale (HAMA) were applied to assess symptoms both at baseline and two weeks after antidepressant treatment. Stepwise multiple linear regression was employed to identify the early efficacy predictors, and a logistic regression model was built with the above serum proteins. The area under the receiver operating characteristic (AUC) curve was calculated to evaluate the model’s diagnostic power.Results: Multiple linear regression revealed that baseline scores of retardation (β = − 0.432, P = 0.012) and psychological anxiety (β = − 0.423, P = 0.014) factors were negatively associated with the reduction rate of HAMD-17. A simple and efficient diagnostic model using serum BDNF, cortisol, and IFN-gamma levels was established by the forward stepwise logistic regression, and the model achieved an AUC of 0.884, with 86.7% sensitivity and 83.3% specificity.Conclusion: The results showed that combining serum BDNF, cortisol and IFN-gamma could aid the diagnosis of MDD, while baseline retardation and psychological anxiety may predict the poor early symptom improvement.Keywords: major depressive disorder, inflammation factors, cortisol, neurotrophic factors, objective diagnostic platform, efficacy predictorChen SZhang YYuan YDove Medical Pressarticlemajor depressive disorderinflammation factorscortisolneurotrophic factorsobjective diagnostic platformefficacy predictorNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 2819-2829 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	major depressive disorder inflammation factors cortisol neurotrophic factors objective diagnostic platform efficacy predictor Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	major depressive disorder inflammation factors cortisol neurotrophic factors objective diagnostic platform efficacy predictor Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Chen S Zhang Y Yuan Y The Combination of Serum BDNF, Cortisol and IFN-Gamma Can Assist the Diagnosis of Major Depressive Disorder
description	Suzhen Chen,1,2 Yuqun Zhang,3 Yonggui Yuan1,2 1Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, 210009, People’s Republic of China; 2Institute of Psychosomatics, School of Medicine, Southeast University, Nanjing, 210009, People’s Republic of China; 3School of Nursing, Nanjing University of Chinese Medicine, Nanjing, 210023, People’s Republic of ChinaCorrespondence: Yonggui YuanDepartment of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, No. 87 Dingjiaqiao, Gulou District, Nanjing, 210009, People’s Republic of ChinaTel +86 25- 83285124Email yygylh2000@sina.comPurpose: Misdiagnosis and ineffective treatment are common in major depressive disorder (MDD) in current clinical practice, while the combination of various serum proteins may assist the correct diagnosis. The study aimed to explore whether the combination of serum inflammatory, stress, and neurotrophic factors could be helpful for the diagnosis of MDD and to investigate the predictors associated with early symptom improvements.Patients and Methods: Baseline serum levels of C-reactive protein (CRP), interleukin (IL)-6, IL-10, IL-1beta, tumor necrosis factor (TNF)-alpha, interferon (INF)-gamma, cortisol, and brain-derived neurotrophic factor (BDNF) were detected in 30 MDD patients and 30 age- and gender-matched healthy controls. 17-item Hamilton Depression Rating Scale (HAMD-17) and Hamilton Anxiety Rating Scale (HAMA) were applied to assess symptoms both at baseline and two weeks after antidepressant treatment. Stepwise multiple linear regression was employed to identify the early efficacy predictors, and a logistic regression model was built with the above serum proteins. The area under the receiver operating characteristic (AUC) curve was calculated to evaluate the model’s diagnostic power.Results: Multiple linear regression revealed that baseline scores of retardation (β = − 0.432, P = 0.012) and psychological anxiety (β = − 0.423, P = 0.014) factors were negatively associated with the reduction rate of HAMD-17. A simple and efficient diagnostic model using serum BDNF, cortisol, and IFN-gamma levels was established by the forward stepwise logistic regression, and the model achieved an AUC of 0.884, with 86.7% sensitivity and 83.3% specificity.Conclusion: The results showed that combining serum BDNF, cortisol and IFN-gamma could aid the diagnosis of MDD, while baseline retardation and psychological anxiety may predict the poor early symptom improvement.Keywords: major depressive disorder, inflammation factors, cortisol, neurotrophic factors, objective diagnostic platform, efficacy predictor
format	article
author	Chen S Zhang Y Yuan Y
author_facet	Chen S Zhang Y Yuan Y
author_sort	Chen S
title	The Combination of Serum BDNF, Cortisol and IFN-Gamma Can Assist the Diagnosis of Major Depressive Disorder
title_short	The Combination of Serum BDNF, Cortisol and IFN-Gamma Can Assist the Diagnosis of Major Depressive Disorder
title_full	The Combination of Serum BDNF, Cortisol and IFN-Gamma Can Assist the Diagnosis of Major Depressive Disorder
title_fullStr	The Combination of Serum BDNF, Cortisol and IFN-Gamma Can Assist the Diagnosis of Major Depressive Disorder
title_full_unstemmed	The Combination of Serum BDNF, Cortisol and IFN-Gamma Can Assist the Diagnosis of Major Depressive Disorder
title_sort	combination of serum bdnf, cortisol and ifn-gamma can assist the diagnosis of major depressive disorder
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/63c4edb37a584c91b57bd8633a81d5cf
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The Combination of Serum BDNF, Cortisol and IFN-Gamma Can Assist the Diagnosis of Major Depressive Disorder

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