Association Analysis of Insulin Resistance and Osteoporosis Risk in Chinese Patients with T2DM

Xinshui Wang,1 Lijuan Jiang,2 Xiaonan Shao3 1Department of Endocrinology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, People’s Republic of China; 2Department of Clinical Laboratory, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, People’s Republic...

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Autores principales:	Wang X, Jiang L, Shao X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	type 2 diabetes mellitus insulin resistance osteoporosis bone mineral density homeostasis model assessment for insulin resistance Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/63c6464b70424e0b8a0c7ec37eef665b
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spelling	oai:doaj.org-article:63c6464b70424e0b8a0c7ec37eef665b2021-12-02T18:53:22ZAssociation Analysis of Insulin Resistance and Osteoporosis Risk in Chinese Patients with T2DM1178-203Xhttps://doaj.org/article/63c6464b70424e0b8a0c7ec37eef665b2021-08-01T00:00:00Zhttps://www.dovepress.com/association-analysis-of-insulin-resistance-and-osteoporosis-risk-in-ch-peer-reviewed-fulltext-article-TCRMhttps://doaj.org/toc/1178-203XXinshui Wang,1 Lijuan Jiang,2 Xiaonan Shao3 1Department of Endocrinology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, People’s Republic of China; 2Department of Clinical Laboratory, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, People’s Republic of China; 3Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, People’s Republic of ChinaCorrespondence: Lijuan JiangDepartment of Clinical Laboratory, the Third Affiliated Hospital of Soochow University, Changzhou, 213003, People’s Republic of ChinaTel +86-0-13776885831Fax +86-0519-86621235Email czyyjlj@126.comBackground: To explore the relationship between insulin resistance and osteoporosis risk in Chinese patients with type 2 diabetes mellitus (T2DM).Methods: A total of 234 T2DM patients were retrospectively analyzed, and their lumbar bone mineral density (BMD) and insulin resistance using C-peptide-based homeostasis model of insulin resistance [HOMA-IR (CP)] were assessed. Univariate and multivariable logistic regression methods were used to evaluate the association between HOMA-IR (CP) and osteoporosis, and subgroup analysis was performed on female and male patients.Results: After fully adjusting the covariates, the association between HOMA-IR (CP) and osteoporosis was only significant in female patients (P = 0.022); the interaction effect with gender was significant (P for interaction < 0.05). Curve fitting showed that the relationship between HOMA-IR (CP) and osteoporosis in women was nonlinear. When HOMA-IR (CP) is < 4.00, its effect on osteoporosis was not significant (P = 0.474); when HOMA-IR (CP) is > 4.00, the risk of osteoporosis increased significantly, with OR = 26.88 (95% CI: 2.75– 262.69, P = 0.005). The relationship between insulin resistance and osteoporosis risk in T2DM patients is significantly affected by gender.Conclusion: The higher the degree of insulin resistance in female patients, the greater the risk of osteoporosis, but the two are not linearly associated.Keywords: type 2 diabetes mellitus, insulin resistance, osteoporosis, bone mineral density, homeostasis model assessment for insulin resistanceWang XJiang LShao XDove Medical Pressarticletype 2 diabetes mellitusinsulin resistanceosteoporosisbone mineral densityhomeostasis model assessment for insulin resistanceTherapeutics. PharmacologyRM1-950ENTherapeutics and Clinical Risk Management, Vol Volume 17, Pp 909-916 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	type 2 diabetes mellitus insulin resistance osteoporosis bone mineral density homeostasis model assessment for insulin resistance Therapeutics. Pharmacology RM1-950
spellingShingle	type 2 diabetes mellitus insulin resistance osteoporosis bone mineral density homeostasis model assessment for insulin resistance Therapeutics. Pharmacology RM1-950 Wang X Jiang L Shao X Association Analysis of Insulin Resistance and Osteoporosis Risk in Chinese Patients with T2DM
description	Xinshui Wang,1 Lijuan Jiang,2 Xiaonan Shao3 1Department of Endocrinology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, People’s Republic of China; 2Department of Clinical Laboratory, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, People’s Republic of China; 3Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, People’s Republic of ChinaCorrespondence: Lijuan JiangDepartment of Clinical Laboratory, the Third Affiliated Hospital of Soochow University, Changzhou, 213003, People’s Republic of ChinaTel +86-0-13776885831Fax +86-0519-86621235Email czyyjlj@126.comBackground: To explore the relationship between insulin resistance and osteoporosis risk in Chinese patients with type 2 diabetes mellitus (T2DM).Methods: A total of 234 T2DM patients were retrospectively analyzed, and their lumbar bone mineral density (BMD) and insulin resistance using C-peptide-based homeostasis model of insulin resistance [HOMA-IR (CP)] were assessed. Univariate and multivariable logistic regression methods were used to evaluate the association between HOMA-IR (CP) and osteoporosis, and subgroup analysis was performed on female and male patients.Results: After fully adjusting the covariates, the association between HOMA-IR (CP) and osteoporosis was only significant in female patients (P = 0.022); the interaction effect with gender was significant (P for interaction < 0.05). Curve fitting showed that the relationship between HOMA-IR (CP) and osteoporosis in women was nonlinear. When HOMA-IR (CP) is < 4.00, its effect on osteoporosis was not significant (P = 0.474); when HOMA-IR (CP) is > 4.00, the risk of osteoporosis increased significantly, with OR = 26.88 (95% CI: 2.75– 262.69, P = 0.005). The relationship between insulin resistance and osteoporosis risk in T2DM patients is significantly affected by gender.Conclusion: The higher the degree of insulin resistance in female patients, the greater the risk of osteoporosis, but the two are not linearly associated.Keywords: type 2 diabetes mellitus, insulin resistance, osteoporosis, bone mineral density, homeostasis model assessment for insulin resistance
format	article
author	Wang X Jiang L Shao X
author_facet	Wang X Jiang L Shao X
author_sort	Wang X
title	Association Analysis of Insulin Resistance and Osteoporosis Risk in Chinese Patients with T2DM
title_short	Association Analysis of Insulin Resistance and Osteoporosis Risk in Chinese Patients with T2DM
title_full	Association Analysis of Insulin Resistance and Osteoporosis Risk in Chinese Patients with T2DM
title_fullStr	Association Analysis of Insulin Resistance and Osteoporosis Risk in Chinese Patients with T2DM
title_full_unstemmed	Association Analysis of Insulin Resistance and Osteoporosis Risk in Chinese Patients with T2DM
title_sort	association analysis of insulin resistance and osteoporosis risk in chinese patients with t2dm
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/63c6464b70424e0b8a0c7ec37eef665b
work_keys_str_mv	AT wangx associationanalysisofinsulinresistanceandosteoporosisriskinchinesepatientswitht2dm AT jiangl associationanalysisofinsulinresistanceandosteoporosisriskinchinesepatientswitht2dm AT shaox associationanalysisofinsulinresistanceandosteoporosisriskinchinesepatientswitht2dm
_version_	1718377329755947008

Association Analysis of Insulin Resistance and Osteoporosis Risk in Chinese Patients with T2DM

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