The correlation between Flt3-ITD mutation in dendritic cells with TIM-3 expression in acute myeloid leukemia

Abstract. In general, acute myeloid leukemia (AML) is an aggressive and heterogeneous disease that is characterized by rapid cellular proliferation and high mortality. One of the mutations related to AML is the Flt3-ITD mutation, which is found in approximately 25% of patients. In this mini-review,...

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Autores principales:	Hooriyeh Shapoorian, Hamidreza Zalpoor, Mazdak Ganjalikhani-Hakemi
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Health 2021
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/63c7bff11922444d82250b5d377fb4a5
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spelling	oai:doaj.org-article:63c7bff11922444d82250b5d377fb4a52021-11-25T07:49:34ZThe correlation between Flt3-ITD mutation in dendritic cells with TIM-3 expression in acute myeloid leukemia2543-636810.1097/BS9.0000000000000092https://doaj.org/article/63c7bff11922444d82250b5d377fb4a52021-10-01T00:00:00Zhttp://journals.lww.com/10.1097/BS9.0000000000000092https://doaj.org/toc/2543-6368Abstract. In general, acute myeloid leukemia (AML) is an aggressive and heterogeneous disease that is characterized by rapid cellular proliferation and high mortality. One of the mutations related to AML is the Flt3-ITD mutation, which is found in approximately 25% of patients. In this mini-review, we investigate the function of dendritic cells and T cells based on Flt3-ITD mutation and immune evasion as a result of this abnormality. Finally, we discuss some AML therapeutic strategies, including targeting Flt3 on DCs and TIM-3 on T cells as immune receptors to treat this hematopoietic malignancy.Hooriyeh ShapoorianHamidreza ZalpoorMazdak Ganjalikhani-HakemiWolters Kluwer HealtharticleDiseases of the blood and blood-forming organsRC633-647.5ENBlood Science, Vol 3, Iss 4, Pp 132-135 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Hooriyeh Shapoorian Hamidreza Zalpoor Mazdak Ganjalikhani-Hakemi The correlation between Flt3-ITD mutation in dendritic cells with TIM-3 expression in acute myeloid leukemia
description	Abstract. In general, acute myeloid leukemia (AML) is an aggressive and heterogeneous disease that is characterized by rapid cellular proliferation and high mortality. One of the mutations related to AML is the Flt3-ITD mutation, which is found in approximately 25% of patients. In this mini-review, we investigate the function of dendritic cells and T cells based on Flt3-ITD mutation and immune evasion as a result of this abnormality. Finally, we discuss some AML therapeutic strategies, including targeting Flt3 on DCs and TIM-3 on T cells as immune receptors to treat this hematopoietic malignancy.
format	article
author	Hooriyeh Shapoorian Hamidreza Zalpoor Mazdak Ganjalikhani-Hakemi
author_facet	Hooriyeh Shapoorian Hamidreza Zalpoor Mazdak Ganjalikhani-Hakemi
author_sort	Hooriyeh Shapoorian
title	The correlation between Flt3-ITD mutation in dendritic cells with TIM-3 expression in acute myeloid leukemia
title_short	The correlation between Flt3-ITD mutation in dendritic cells with TIM-3 expression in acute myeloid leukemia
title_full	The correlation between Flt3-ITD mutation in dendritic cells with TIM-3 expression in acute myeloid leukemia
title_fullStr	The correlation between Flt3-ITD mutation in dendritic cells with TIM-3 expression in acute myeloid leukemia
title_full_unstemmed	The correlation between Flt3-ITD mutation in dendritic cells with TIM-3 expression in acute myeloid leukemia
title_sort	correlation between flt3-itd mutation in dendritic cells with tim-3 expression in acute myeloid leukemia
publisher	Wolters Kluwer Health
publishDate	2021
url	https://doaj.org/article/63c7bff11922444d82250b5d377fb4a5
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The correlation between Flt3-ITD mutation in dendritic cells with TIM-3 expression in acute myeloid leukemia

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