Diabetes promotes DMH-induced colorectal cancer by increasing the activity of glycolytic enzymes in rats.

The objective of the present study was to investigate the association between diabetes mellitus and colorectal carcinogenesis as well as the possible mechanism involved in this interaction. Diabetes rat models were induced with a low dose of STZ followed by a low dose of DMH to induce colorectal can...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yanglei Jia, Gang Xu, Wenjing Zhou, Zhenzheng Wang, Linlin Meng, Songnan Zhou, Xia Xu, Huiqing Yuan, Keli Tian
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/63cbce3a03d84613bc7f004e1aabbed6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:63cbce3a03d84613bc7f004e1aabbed6
record_format	dspace
spelling	oai:doaj.org-article:63cbce3a03d84613bc7f004e1aabbed62021-11-25T05:56:10ZDiabetes promotes DMH-induced colorectal cancer by increasing the activity of glycolytic enzymes in rats.1932-620310.1371/journal.pone.0110455https://doaj.org/article/63cbce3a03d84613bc7f004e1aabbed62014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0110455https://doaj.org/toc/1932-6203The objective of the present study was to investigate the association between diabetes mellitus and colorectal carcinogenesis as well as the possible mechanism involved in this interaction. Diabetes rat models were induced with a low dose of STZ followed by a low dose of DMH to induce colorectal cancer. The formation of ACF in the colon and the incidence, number and size of tumors were measured. The activity of glycolytic enzymes in colonic tissues was also measured. The results demonstrated that both the total number of ACF and the number of foci that contain a different number of crypts were increased in diabetic rats. At the end of the experimental treatment, the incidence, number and size of tumors were also increased in diabetic rats. Overall, these data indicated that diabetes increased the risk of colorectal cancer. The activity of HK and PK in colonic tissues was increased in diabetic rats, whereas the activity of PDH was decreased. In addition, the activities of these enzymes in intratumor were higher than that of in peritumor. These data indicated that the high rate of glycolysis may play a role in colorectal carcinogenesis in diabetic rats.Yanglei JiaGang XuWenjing ZhouZhenzheng WangLinlin MengSongnan ZhouXia XuHuiqing YuanKeli TianPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 10, p e110455 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yanglei Jia Gang Xu Wenjing Zhou Zhenzheng Wang Linlin Meng Songnan Zhou Xia Xu Huiqing Yuan Keli Tian Diabetes promotes DMH-induced colorectal cancer by increasing the activity of glycolytic enzymes in rats.
description	The objective of the present study was to investigate the association between diabetes mellitus and colorectal carcinogenesis as well as the possible mechanism involved in this interaction. Diabetes rat models were induced with a low dose of STZ followed by a low dose of DMH to induce colorectal cancer. The formation of ACF in the colon and the incidence, number and size of tumors were measured. The activity of glycolytic enzymes in colonic tissues was also measured. The results demonstrated that both the total number of ACF and the number of foci that contain a different number of crypts were increased in diabetic rats. At the end of the experimental treatment, the incidence, number and size of tumors were also increased in diabetic rats. Overall, these data indicated that diabetes increased the risk of colorectal cancer. The activity of HK and PK in colonic tissues was increased in diabetic rats, whereas the activity of PDH was decreased. In addition, the activities of these enzymes in intratumor were higher than that of in peritumor. These data indicated that the high rate of glycolysis may play a role in colorectal carcinogenesis in diabetic rats.
format	article
author	Yanglei Jia Gang Xu Wenjing Zhou Zhenzheng Wang Linlin Meng Songnan Zhou Xia Xu Huiqing Yuan Keli Tian
author_facet	Yanglei Jia Gang Xu Wenjing Zhou Zhenzheng Wang Linlin Meng Songnan Zhou Xia Xu Huiqing Yuan Keli Tian
author_sort	Yanglei Jia
title	Diabetes promotes DMH-induced colorectal cancer by increasing the activity of glycolytic enzymes in rats.
title_short	Diabetes promotes DMH-induced colorectal cancer by increasing the activity of glycolytic enzymes in rats.
title_full	Diabetes promotes DMH-induced colorectal cancer by increasing the activity of glycolytic enzymes in rats.
title_fullStr	Diabetes promotes DMH-induced colorectal cancer by increasing the activity of glycolytic enzymes in rats.
title_full_unstemmed	Diabetes promotes DMH-induced colorectal cancer by increasing the activity of glycolytic enzymes in rats.
title_sort	diabetes promotes dmh-induced colorectal cancer by increasing the activity of glycolytic enzymes in rats.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/63cbce3a03d84613bc7f004e1aabbed6
work_keys_str_mv	AT yangleijia diabetespromotesdmhinducedcolorectalcancerbyincreasingtheactivityofglycolyticenzymesinrats AT gangxu diabetespromotesdmhinducedcolorectalcancerbyincreasingtheactivityofglycolyticenzymesinrats AT wenjingzhou diabetespromotesdmhinducedcolorectalcancerbyincreasingtheactivityofglycolyticenzymesinrats AT zhenzhengwang diabetespromotesdmhinducedcolorectalcancerbyincreasingtheactivityofglycolyticenzymesinrats AT linlinmeng diabetespromotesdmhinducedcolorectalcancerbyincreasingtheactivityofglycolyticenzymesinrats AT songnanzhou diabetespromotesdmhinducedcolorectalcancerbyincreasingtheactivityofglycolyticenzymesinrats AT xiaxu diabetespromotesdmhinducedcolorectalcancerbyincreasingtheactivityofglycolyticenzymesinrats AT huiqingyuan diabetespromotesdmhinducedcolorectalcancerbyincreasingtheactivityofglycolyticenzymesinrats AT kelitian diabetespromotesdmhinducedcolorectalcancerbyincreasingtheactivityofglycolyticenzymesinrats
_version_	1718414343072120832

Diabetes promotes DMH-induced colorectal cancer by increasing the activity of glycolytic enzymes in rats.

Ejemplares similares