Use of Antibiotics among Residents Living Close to Poultry or Goat Farms: A Nationwide Analysis in The Netherlands

Prior regional studies found a high risk of pneumonia for people living close to poultry and goat farms. This epidemiological study in the Netherlands used nationwide antibiotic prescription data as a proxy for pneumonia incidence to investigate whether residents of areas with poultry and goat farms...

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Autores principales:	Inge Roof, Wim van der Hoek, Lisette Oude Boerrigter, Cornelia C. H. Wielders, Lidwien A. M. Smit
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antibiotic use pneumonia livestock human poultry goat Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/63cc1ab204bf417b8ad97da0c380c5b7
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spelling	oai:doaj.org-article:63cc1ab204bf417b8ad97da0c380c5b72021-11-25T16:23:15ZUse of Antibiotics among Residents Living Close to Poultry or Goat Farms: A Nationwide Analysis in The Netherlands10.3390/antibiotics101113462079-6382https://doaj.org/article/63cc1ab204bf417b8ad97da0c380c5b72021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1346https://doaj.org/toc/2079-6382Prior regional studies found a high risk of pneumonia for people living close to poultry and goat farms. This epidemiological study in the Netherlands used nationwide antibiotic prescription data as a proxy for pneumonia incidence to investigate whether residents of areas with poultry and goat farms use relatively more antibiotics compared to areas without such farms. We used prescription data on antibiotics most commonly prescribed to treat pneumonia in adults and livestock farming data, both with nationwide coverage. Antibiotic use was expressed as defined daily doses per (4-digit Postal Code (PC4) area)-(age group)-(gender)-(month) combination for the year 2015. We assessed the associations between antibiotic use and farm exposure using negative binomial regression. The amoxicillin, doxycycline, and co-amoxiclav use was significantly higher (5–10% difference in use) in PC4 areas with poultry farms present compared to areas without, even after adjusting for age, gender, smoking, socio-economic status, and goat farm presence. The adjusted models showed no associations between antibiotic use and goat farm presence. The variables included in this study could only partly explain the observed regional differences in antibiotic use. This was an ecological study that precludes inference about causal relations. Further research using individual-level data is recommended.Inge RoofWim van der HoekLisette Oude BoerrigterCornelia C. H. WieldersLidwien A. M. SmitMDPI AGarticleantibiotic usepneumonialivestockhumanpoultrygoatTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1346, p 1346 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antibiotic use pneumonia livestock human poultry goat Therapeutics. Pharmacology RM1-950
spellingShingle	antibiotic use pneumonia livestock human poultry goat Therapeutics. Pharmacology RM1-950 Inge Roof Wim van der Hoek Lisette Oude Boerrigter Cornelia C. H. Wielders Lidwien A. M. Smit Use of Antibiotics among Residents Living Close to Poultry or Goat Farms: A Nationwide Analysis in The Netherlands
description	Prior regional studies found a high risk of pneumonia for people living close to poultry and goat farms. This epidemiological study in the Netherlands used nationwide antibiotic prescription data as a proxy for pneumonia incidence to investigate whether residents of areas with poultry and goat farms use relatively more antibiotics compared to areas without such farms. We used prescription data on antibiotics most commonly prescribed to treat pneumonia in adults and livestock farming data, both with nationwide coverage. Antibiotic use was expressed as defined daily doses per (4-digit Postal Code (PC4) area)-(age group)-(gender)-(month) combination for the year 2015. We assessed the associations between antibiotic use and farm exposure using negative binomial regression. The amoxicillin, doxycycline, and co-amoxiclav use was significantly higher (5–10% difference in use) in PC4 areas with poultry farms present compared to areas without, even after adjusting for age, gender, smoking, socio-economic status, and goat farm presence. The adjusted models showed no associations between antibiotic use and goat farm presence. The variables included in this study could only partly explain the observed regional differences in antibiotic use. This was an ecological study that precludes inference about causal relations. Further research using individual-level data is recommended.
format	article
author	Inge Roof Wim van der Hoek Lisette Oude Boerrigter Cornelia C. H. Wielders Lidwien A. M. Smit
author_facet	Inge Roof Wim van der Hoek Lisette Oude Boerrigter Cornelia C. H. Wielders Lidwien A. M. Smit
author_sort	Inge Roof
title	Use of Antibiotics among Residents Living Close to Poultry or Goat Farms: A Nationwide Analysis in The Netherlands
title_short	Use of Antibiotics among Residents Living Close to Poultry or Goat Farms: A Nationwide Analysis in The Netherlands
title_full	Use of Antibiotics among Residents Living Close to Poultry or Goat Farms: A Nationwide Analysis in The Netherlands
title_fullStr	Use of Antibiotics among Residents Living Close to Poultry or Goat Farms: A Nationwide Analysis in The Netherlands
title_full_unstemmed	Use of Antibiotics among Residents Living Close to Poultry or Goat Farms: A Nationwide Analysis in The Netherlands
title_sort	use of antibiotics among residents living close to poultry or goat farms: a nationwide analysis in the netherlands
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/63cc1ab204bf417b8ad97da0c380c5b7
work_keys_str_mv	AT ingeroof useofantibioticsamongresidentslivingclosetopoultryorgoatfarmsanationwideanalysisinthenetherlands AT wimvanderhoek useofantibioticsamongresidentslivingclosetopoultryorgoatfarmsanationwideanalysisinthenetherlands AT lisetteoudeboerrigter useofantibioticsamongresidentslivingclosetopoultryorgoatfarmsanationwideanalysisinthenetherlands AT corneliachwielders useofantibioticsamongresidentslivingclosetopoultryorgoatfarmsanationwideanalysisinthenetherlands AT lidwienamsmit useofantibioticsamongresidentslivingclosetopoultryorgoatfarmsanationwideanalysisinthenetherlands
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Use of Antibiotics among Residents Living Close to Poultry or Goat Farms: A Nationwide Analysis in The Netherlands

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