openSNP--a crowdsourced web resource for personal genomics.

Genome-Wide Association Studies are widely used to correlate phenotypic traits with genetic variants. These studies usually compare the genetic variation between two groups to single out certain Single Nucleotide Polymorphisms (SNPs) that are linked to a phenotypic variation in one of the groups. Ho...

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Autores principales:	Bastian Greshake, Philipp E Bayer, Helge Rausch, Julia Reda
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/63d10fd71b2d483083bba04f552507fa
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spelling	oai:doaj.org-article:63d10fd71b2d483083bba04f552507fa2021-11-18T08:27:20ZopenSNP--a crowdsourced web resource for personal genomics.1932-620310.1371/journal.pone.0089204https://doaj.org/article/63d10fd71b2d483083bba04f552507fa2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24647222/?tool=EBIhttps://doaj.org/toc/1932-6203Genome-Wide Association Studies are widely used to correlate phenotypic traits with genetic variants. These studies usually compare the genetic variation between two groups to single out certain Single Nucleotide Polymorphisms (SNPs) that are linked to a phenotypic variation in one of the groups. However, it is necessary to have a large enough sample size to find statistically significant correlations. Direct-To-Consumer (DTC) genetic testing can supply additional data: DTC-companies offer the analysis of a large amount of SNPs for an individual at low cost without the need to consult a physician or geneticist. Over 100,000 people have already been genotyped through Direct-To-Consumer genetic testing companies. However, this data is not public for a variety of reasons and thus cannot be used in research. It seems reasonable to create a central open data repository for such data. Here we present the web platform openSNP, an open database which allows participants of Direct-To-Consumer genetic testing to publish their genetic data at no cost along with phenotypic information. Through this crowdsourced effort of collecting genetic and phenotypic information, openSNP has become a resource for a wide area of studies, including Genome-Wide Association Studies. openSNP is hosted at http://www.opensnp.org, and the code is released under MIT-license at http://github.com/gedankenstuecke/snpr.Bastian GreshakePhilipp E BayerHelge RauschJulia RedaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e89204 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bastian Greshake Philipp E Bayer Helge Rausch Julia Reda openSNP--a crowdsourced web resource for personal genomics.
description	Genome-Wide Association Studies are widely used to correlate phenotypic traits with genetic variants. These studies usually compare the genetic variation between two groups to single out certain Single Nucleotide Polymorphisms (SNPs) that are linked to a phenotypic variation in one of the groups. However, it is necessary to have a large enough sample size to find statistically significant correlations. Direct-To-Consumer (DTC) genetic testing can supply additional data: DTC-companies offer the analysis of a large amount of SNPs for an individual at low cost without the need to consult a physician or geneticist. Over 100,000 people have already been genotyped through Direct-To-Consumer genetic testing companies. However, this data is not public for a variety of reasons and thus cannot be used in research. It seems reasonable to create a central open data repository for such data. Here we present the web platform openSNP, an open database which allows participants of Direct-To-Consumer genetic testing to publish their genetic data at no cost along with phenotypic information. Through this crowdsourced effort of collecting genetic and phenotypic information, openSNP has become a resource for a wide area of studies, including Genome-Wide Association Studies. openSNP is hosted at http://www.opensnp.org, and the code is released under MIT-license at http://github.com/gedankenstuecke/snpr.
format	article
author	Bastian Greshake Philipp E Bayer Helge Rausch Julia Reda
author_facet	Bastian Greshake Philipp E Bayer Helge Rausch Julia Reda
author_sort	Bastian Greshake
title	openSNP--a crowdsourced web resource for personal genomics.
title_short	openSNP--a crowdsourced web resource for personal genomics.
title_full	openSNP--a crowdsourced web resource for personal genomics.
title_fullStr	openSNP--a crowdsourced web resource for personal genomics.
title_full_unstemmed	openSNP--a crowdsourced web resource for personal genomics.
title_sort	opensnp--a crowdsourced web resource for personal genomics.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/63d10fd71b2d483083bba04f552507fa
work_keys_str_mv	AT bastiangreshake opensnpacrowdsourcedwebresourceforpersonalgenomics AT philippebayer opensnpacrowdsourcedwebresourceforpersonalgenomics AT helgerausch opensnpacrowdsourcedwebresourceforpersonalgenomics AT juliareda opensnpacrowdsourcedwebresourceforpersonalgenomics
_version_	1718421743628976128

openSNP--a crowdsourced web resource for personal genomics.

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